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NAD(P)-linked oxidoreductase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   NAD(P)-linked oxidoreductase [ 51430]
Families:   Aldo-keto reductases (NADP) [ 51431] (15)


Superfamily statistics
Genomes (2,708) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 25,569 127,222 47
Proteins 25,361 126,697 47


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.000000000037650Least InformativeDirect
Biological Process (BP)biological regulation11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.58930.5951Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process0.23111Least InformativeInherited
Biological Process (BP)response to stimulus0.54891Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process0.94410.9425Least InformativeInherited
Biological Process (BP)multicellular organismal process0.60171Least InformativeInherited
Biological Process (BP)lipid metabolic process0.0000070860.000002374Moderately InformativeDirect
Biological Process (BP)oxidation-reduction process0.00019460.000003099Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process0.83451Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)cellular localization0.74031Moderately InformativeInherited
Biological Process (BP)single-organism transport0.98091Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process0.10670.000106Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.85641Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.008980.4272Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.00048370.09283Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.011910.01169Moderately InformativeInherited
Biological Process (BP)regulation of signaling0.28371Moderately InformativeInherited
Biological Process (BP)regulation of cell communication0.18311Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.67581Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.54821Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.8551Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.42020.2985Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.000013140.09677Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.0054640.3931Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.018080.02841Moderately InformativeInherited
Biological Process (BP)response to organic substance11Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.42460.2536Moderately InformativeInherited
Biological Process (BP)organic substance transport0.72220.9397Moderately InformativeInherited
Biological Process (BP)nitrogen compound transport0.7320.9233Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.25190.3913Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.017330.008037Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.41670.4999Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.054350.04011Moderately InformativeInherited
Biological Process (BP)amide biosynthetic process0.17910.3341Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.20570.06145Moderately InformativeInherited
Biological Process (BP)peptide metabolic process0.10160.3644Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.82490.6876Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.001010.0001307Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.27920.9808Moderately InformativeInherited
Biological Process (BP)response to acid chemical0.00064270.0002458InformativeDirect
Biological Process (BP)monosaccharide metabolic process0.00000058530.0000001628InformativeDirect
Biological Process (BP)alcohol metabolic process0.00000030720.0004639InformativeDirect
Biological Process (BP)cellular aldehyde metabolic process00InformativeDirect
Biological Process (BP)isoprenoid metabolic process0.0000002770.00000001963InformativeDirect
Biological Process (BP)response to oxidative stress0.000000015560.0000002035InformativeDirect
Biological Process (BP)regulation of hormone levels0.000000085340.0000000008047InformativeDirect
Biological Process (BP)cellular response to hormone stimulus0.0000035430.0006865InformativeDirect
Biological Process (BP)cellular ketone metabolic process00InformativeDirect
Biological Process (BP)ammonium ion metabolic process0.000000010730.00000000968InformativeDirect
Biological Process (BP)organic hydroxy compound biosynthetic process0.0000001060.00000009824InformativeDirect
Biological Process (BP)regulation of apoptotic process0.018130.3918InformativeInherited
Biological Process (BP)single-organism cellular localization0.020430.266InformativeInherited
Biological Process (BP)negative regulation of cellular biosynthetic process0.035971InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.019010.03566InformativeInherited
Biological Process (BP)cellular response to lipid0.00078770.007846InformativeInherited
Biological Process (BP)response to organic cyclic compound0.011050.3176InformativeInherited
Biological Process (BP)cellular response to inorganic substance0.17890.02455InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.033340.6151InformativeInherited
Biological Process (BP)regulation of intracellular signal transduction0.038360.7921InformativeInherited
Biological Process (BP)response to metal ion0.16670.09606InformativeInherited
Biological Process (BP)carbohydrate catabolic process0.059170.005879InformativeInherited
Biological Process (BP)regulation of lipid metabolic process0.00024540.005439InformativeInherited
Biological Process (BP)secondary metabolic process0.00009950.001242InformativeInherited
Biological Process (BP)glycosyl compound metabolic process0.0024870.000314InformativeInherited
Biological Process (BP)regulation of anatomical structure size0.17670.4503InformativeInherited
Biological Process (BP)protein transport0.12060.4193InformativeInherited
Biological Process (BP)lipid catabolic process0.0020560.002996InformativeInherited
Biological Process (BP)sulfur compound biosynthetic process0.010720.0024InformativeInherited
Biological Process (BP)cellular modified amino acid metabolic process0.0033140.00155InformativeInherited
Biological Process (BP)intracellular transport0.38270.9075InformativeInherited
Biological Process (BP)glutamine family amino acid metabolic process0.0032310.002067InformativeInherited
Biological Process (BP)dicarboxylic acid metabolic process0.03760.03957InformativeInherited
Biological Process (BP)system process0.017960.295InformativeInherited
Biological Process (BP)protein localization to organelle0.010150.08062InformativeInherited
Biological Process (BP)glutamate metabolic process0.000043810.0000179Highly InformativeDirect
Biological Process (BP)steroid biosynthetic process0.0000000000054080.0000000003368Highly InformativeDirect
Biological Process (BP)glutathione metabolic process0.00000088850.000004972Highly InformativeDirect
Biological Process (BP)xenobiotic metabolic process0.0000055850.000001392Highly InformativeDirect
Biological Process (BP)digestion0.000000016090.00000002808Highly InformativeDirect
Biological Process (BP)regulation of cellular ketone metabolic process0.000033760.0004796Highly InformativeDirect
Biological Process (BP)diterpenoid metabolic process0.000000000000094010Highly InformativeDirect
Biological Process (BP)glycoside metabolic process0.0000000000004240Highly InformativeDirect
Biological Process (BP)protein import0.00004440.0006649Highly InformativeDirect
Biological Process (BP)nonribosomal peptide biosynthetic process0.00000079640.0000004847Highly InformativeDirect
Biological Process (BP)polyketide metabolic process0.000000000000020640Highly InformativeDirect
Biological Process (BP)primary alcohol metabolic process0.00067690.000001349Highly InformativeDirect
Biological Process (BP)protein localization to nucleus0.000017450.0004691Highly InformativeDirect
Biological Process (BP)cellular hormone metabolic process00Highly InformativeDirect
Biological Process (BP)ketone biosynthetic process0.000057390.00001239Highly InformativeDirect
Biological Process (BP)ketone catabolic process0.000018440.0000005269Highly InformativeDirect
Biological Process (BP)cellular modified amino acid biosynthetic process0.00001170.000002068Highly InformativeDirect
Biological Process (BP)negative regulation of lipid metabolic process0.0000065510.000007636Highly InformativeDirect
Biological Process (BP)monosaccharide catabolic process0.00016640.00003449Highly InformativeDirect
Biological Process (BP)regulation of steroid biosynthetic process0.000000031280.00000007757Highly InformativeDirect
Biological Process (BP)positive regulation of protein kinase B signaling0.00000016260.000001192Highly InformativeDirect
Biological Process (BP)response to fatty acid0.00000062410.0000001498Highly InformativeDirect
Biological Process (BP)cellular response to acid chemical0.00003410.00001007Highly InformativeDirect
Biological Process (BP)cellular response to cadmium ion0.000029460.000005645Highly InformativeDirect
Biological Process (BP)cellular response to calcium ion0.000000012610.0000005239Highly InformativeDirect
Biological Process (BP)cellular response to steroid hormone stimulus0.00033060.0002311Highly InformativeDirect
Biological Process (BP)quinone metabolic process0.00000038430.0000005627Highly InformativeDirect
Biological Process (BP)single-organism nuclear import0.0000051810.0001391Highly InformativeDirect
Biological Process (BP)positive regulation of reactive oxygen species metabolic process0.0000070670.00003065Highly InformativeDirect
Biological Process (BP)positive regulation of apoptotic process0.028980.07493Highly InformativeInherited
Biological Process (BP)alcohol catabolic process0.0017280.0002345Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)small molecule binding0.011040.0002065Moderately InformativeInherited
Molecular Function (MF)anion binding0.014240.002016Moderately InformativeInherited
Molecular Function (MF)coenzyme binding0.00000030240.000000000038InformativeDirect
Molecular Function (MF)enzyme binding0.065270.7639InformativeInherited
Molecular Function (MF)carboxylic acid binding0.010750.01388InformativeInherited
Molecular Function (MF)ligase activity0.063540.4681InformativeInherited
Molecular Function (MF)steroid binding0.000001240.0000006895Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor00Highly InformativeDirect
Molecular Function (MF)acid-amino acid ligase activity0.0000011360.000011Highly InformativeDirect
Molecular Function (MF)monocarboxylic acid binding0.00009130.000006218Highly InformativeDirect
Molecular Function (MF)NADP binding0.000000000049180Highly InformativeDirect
Molecular Function (MF)monooxygenase activity0.14071Highly InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge0.55481Highly InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on the CH-CH group of donors0.028060.06663Highly InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on the aldehyde or oxo group of donors0.4170.7223Highly InformativeInherited
Cellular Component (CC)cytoplasmic part0.0053150.009675Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.5951 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.9425 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.0001307 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0.000002374 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.000106 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.000003099 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.4272 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.09283 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.01169 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.8062 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.125 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.003023 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.09677 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.3931 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.02841 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.2536 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.9397 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.9233 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.3913 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.008037 Moderately Informative Inherited
Biological Process (BP) ion transport 0.05267 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.4999 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.2985 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.04011 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 0.3341 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.06145 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 0.3644 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.6876 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.9808 Moderately Informative Inherited
Biological Process (BP) response to acid chemical 0.0002458 Informative Direct
Biological Process (BP) monosaccharide metabolic process 0.0000001628 Informative Direct
Biological Process (BP) alcohol metabolic process 0.0004639 Informative Direct
Biological Process (BP) cellular aldehyde metabolic process 0 Informative Direct
Biological Process (BP) isoprenoid metabolic process 0.00000001963 Informative Direct
Biological Process (BP) response to oxidative stress 0.0000002035 Informative Direct
Biological Process (BP) regulation of hormone levels 0.0000000008047 Informative Direct
Biological Process (BP) metal ion transport 0.0004316 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0.0006865 Informative Direct
Biological Process (BP) regulation of transmembrane transport 0.000004401 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0 Informative Direct
Biological Process (BP) regulation of ion transport 0.0003098 Informative Direct
Biological Process (BP) protein oligomerization 0.000002393 Informative Direct
Biological Process (BP) pyridine-containing compound metabolic process 0.0008153 Informative Direct
Biological Process (BP) ammonium ion metabolic process 0.00000000968 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.00000009824 Informative Direct
Biological Process (BP) glycosyl compound metabolic process 0.000314 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.3918 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.266 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.03566 Informative Inherited
Biological Process (BP) cellular response to lipid 0.007846 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.3176 Informative Inherited
Biological Process (BP) cellular response to inorganic substance 0.02455 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.6151 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.7921 Informative Inherited
Biological Process (BP) response to metal ion 0.09606 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 0.005879 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.638 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.005439 Informative Inherited
Biological Process (BP) secondary metabolic process 0.001242 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.4503 Informative Inherited
Biological Process (BP) behavior 0.01485 Informative Inherited
Biological Process (BP) protein transport 0.4193 Informative Inherited
Biological Process (BP) lipid catabolic process 0.002996 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.0024 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.00155 Informative Inherited
Biological Process (BP) intracellular transport 0.9075 Informative Inherited
Biological Process (BP) glutamine family amino acid metabolic process 0.002067 Informative Inherited
Biological Process (BP) dicarboxylic acid metabolic process 0.03957 Informative Inherited
Biological Process (BP) system process 0.295 Informative Inherited
Biological Process (BP) protein localization to organelle 0.08062 Informative Inherited
Biological Process (BP) glutamate metabolic process 0.0000179 Highly Informative Direct
Biological Process (BP) steroid biosynthetic process 0.0000000003368 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 0.000004972 Highly Informative Direct
Biological Process (BP) xenobiotic metabolic process 0.000001392 Highly Informative Direct
Biological Process (BP) digestion 0.00000002808 Highly Informative Direct
Biological Process (BP) circadian rhythm 0.00001801 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0.0004796 Highly Informative Direct
Biological Process (BP) diterpenoid metabolic process 0 Highly Informative Direct
Biological Process (BP) glycoside metabolic process 0 Highly Informative Direct
Biological Process (BP) protein import 0.0006649 Highly Informative Direct
Biological Process (BP) nonribosomal peptide biosynthetic process 0.0000004847 Highly Informative Direct
Biological Process (BP) polyketide metabolic process 0 Highly Informative Direct
Biological Process (BP) primary alcohol metabolic process 0.000001349 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 0.0004691 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 0.000698 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 0 Highly Informative Direct
Biological Process (BP) ketone biosynthetic process 0.00001239 Highly Informative Direct
Biological Process (BP) ketone catabolic process 0.0000005269 Highly Informative Direct
Biological Process (BP) cellular modified amino acid biosynthetic process 0.000002068 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0.000002168 Highly Informative Direct
Biological Process (BP) single-organism behavior 0.0003103 Highly Informative Direct
Biological Process (BP) negative regulation of lipid metabolic process 0.000007636 Highly Informative Direct
Biological Process (BP) alcohol catabolic process 0.0002345 Highly Informative Direct
Biological Process (BP) monosaccharide catabolic process 0.00003449 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 0.00000007757 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase B signaling 0.000001192 Highly Informative Direct
Biological Process (BP) response to fatty acid 0.0000001498 Highly Informative Direct
Biological Process (BP) cellular response to acid chemical 0.00001007 Highly Informative Direct
Biological Process (BP) cellular response to cadmium ion 0.000005645 Highly Informative Direct
Biological Process (BP) cellular response to calcium ion 0.0000005239 Highly Informative Direct
Biological Process (BP) cellular response to steroid hormone stimulus 0.0002311 Highly Informative Direct
Biological Process (BP) quinone metabolic process 0.0000005627 Highly Informative Direct
Biological Process (BP) single-organism nuclear import 0.0001391 Highly Informative Direct
Biological Process (BP) regulation of cation transmembrane transport 0.0000005657 Highly Informative Direct
Biological Process (BP) positive regulation of reactive oxygen species metabolic process 0.00003065 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic process 0.07493 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transporter activity 0.8326 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.001278 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.0002065 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.00002305 Moderately Informative Direct
Molecular Function (MF) anion binding 0.002016 Moderately Informative Inherited
Molecular Function (MF) transporter activity 0.8159 Moderately Informative Inherited
Molecular Function (MF) coenzyme binding 0.000000000038 Informative Direct
Molecular Function (MF) enzyme binding 0.7639 Informative Inherited
Molecular Function (MF) carboxylic acid binding 0.01388 Informative Inherited
Molecular Function (MF) passive transmembrane transporter activity 0.006518 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.002919 Informative Inherited
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 0.001429 Informative Inherited
Molecular Function (MF) ligase activity 0.4681 Informative Inherited
Molecular Function (MF) steroid binding 0.0000006895 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0 Highly Informative Direct
Molecular Function (MF) acid-amino acid ligase activity 0.000011 Highly Informative Direct
Molecular Function (MF) gated channel activity 0.0006453 Highly Informative Direct
Molecular Function (MF) monocarboxylic acid binding 0.000006218 Highly Informative Direct
Molecular Function (MF) NADP binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors 0.06663 Highly Informative Inherited
Molecular Function (MF) monooxygenase activity 1 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 1 Highly Informative Inherited
Molecular Function (MF) ion channel activity 0.002769 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.7223 Highly Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.009675 Least Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.1502 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) extrinsic component of membrane 0.00001073 Informative Direct
Cellular Component (CC) side of membrane 0.0005985 Informative Direct
Cellular Component (CC) transporter complex 0.000000000008421 Informative Direct
Cellular Component (CC) extrinsic component of cytoplasmic side of plasma membrane 0.0000000003162 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.09917 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-CH group of donors0.4925Moderately InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processCarbohydrate metabolism0.000000000003707Moderately InformativeDirect
Biological processIon transport0.000124Moderately InformativeDirect
Biological processLipid metabolism0.0002636Moderately InformativeDirect
Biological processSteroid metabolism0.0000000008803InformativeDirect
Biological processFatty acid metabolism0.5261InformativeInherited
Biological processAlkaloid metabolism0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processProstaglandin biosynthesis0.0000000000004321Highly InformativeDirect
Molecular functionNADP0Moderately InformativeDirect
Molecular functionNAD0.0000006035Moderately InformativeDirect
Molecular functionPotassium0.000000003375InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationIon channel0.00000000000003738InformativeDirect
Post-translational modificationVoltage-gated channel0Highly InformativeDirect
Post-translational modificationAcetylation0.0000000001946Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001395 SSF51430 Protein matches
Abstract

The aldo-keto reductase family includes a number of related monomeric NADPH-dependent oxidoreductases, such as aldehyde reductase, aldose reductase, prostaglandin F synthase, xylose reductase, rho crystallin, and many others [PubMed2498333]. All possess a similar structure, with a beta-alpha-beta fold characteristic of nucleotide binding proteins [PubMed2105951]. The fold comprises a parallel beta-8/alpha-8-barrel, which contains a novel NADP-binding motif. The binding site is located in a large, deep, elliptical pocket in the C-terminal end of the beta sheet, the substrate being bound in an extended conformation. The hydrophobic nature of the pocket favours aromatic and apolar substrates over highly polar ones [PubMed1621098].

Binding of the NADPH coenzyme causes a massive conformational change, reorienting a loop, effectively locking the coenzyme in place. This binding is more similar to FAD- than to NAD(P)-binding oxidoreductases [PubMed1447221].

Some proteins of this entry contain a K+ ion channel beta chain regulatory domain; these are reported to have oxidoreductase activity [PubMed10884227].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 21 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a NAD(P)-linked oxidoreductase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 21 hidden Markov models representing the NAD(P)-linked oxidoreductase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]