SUPERFAMILY 1.75 HMM library and genome assignments server

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(Trans)glycosidases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   (Trans)glycosidases [ 51445] (14)
Families:   Amylase, catalytic domain [ 51446] (25)
  beta-glycanases [ 51487] (26)
  Putative alpha-L-fucosidase, catalytic domain [ 102079]
  Family 1 of glycosyl hydrolase [ 51521] (5)
  Type II chitinase [ 51534] (14)
  1,4-beta-N-acetylmuraminidase [ 63912] (3)
  beta-N-acetylhexosaminidase catalytic domain [ 51550] (5)
  alpha-D-glucuronidase/Hyaluronidase catalytic domain [ 82253] (3)
  NagZ-like [ 51553] (2)
  Bee venom hyaluronidase [ 69387]
  Outer surface protein, N-terminal domain [ 110354]
  YicI catalytic domain-like [ 117372] (2)
  Glycosyl hydrolases family 35 catalytic domain [ 117375]
  TM1410-like [ 141796]


Superfamily statistics
Genomes (2,998) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 95,150 483,521 385
Proteins 92,734 475,748 385


Functional annotation
General category Metabolism
Detailed category Carbohydrate metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biological regulation11Least InformativeInherited
Biological Process (BP)multicellular organismal process0.37391Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.71471Least InformativeInherited
Biological Process (BP)single-organism metabolic process10Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)response to stimulus0.37611Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)macromolecule metabolic process00.005748Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process00Moderately InformativeDirect
Biological Process (BP)defense response0.000000011060.0000004896Moderately InformativeDirect
Biological Process (BP)response to biotic stimulus0.0000000000020210.0000007083Moderately InformativeDirect
Biological Process (BP)response to abiotic stimulus0.000024140.00009983Moderately InformativeDirect
Biological Process (BP)cellular catabolic process0.0000018760Moderately InformativeDirect
Biological Process (BP)multi-organism process0.0000000000018150.0007782Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process0.00000029340Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process00Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process0.2021Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.00029421Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.00020930.1384Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process11Moderately InformativeInherited
Biological Process (BP)tissue development0.000025841Moderately InformativeInherited
Biological Process (BP)animal organ development0.03461Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.06290Moderately InformativeInherited
Biological Process (BP)lipid metabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.00097041Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.000049990.01283Moderately InformativeInherited
Biological Process (BP)response to organic substance0.16220.4107Moderately InformativeInherited
Biological Process (BP)regulation of localization0.0020231Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.064731Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.0053441Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.00011411Moderately InformativeInherited
Biological Process (BP)response to external stimulus0.000000068920.01331Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.0020890.3978Moderately InformativeInherited
Biological Process (BP)polysaccharide metabolic process00InformativeDirect
Biological Process (BP)response to oxidative stress0.000016970.00000002156InformativeDirect
Biological Process (BP)carbohydrate catabolic process0.000000000000060660InformativeDirect
Biological Process (BP)regulation of anatomical structure morphogenesis0.0000046050.0004181InformativeDirect
Biological Process (BP)cellular carbohydrate metabolic process00InformativeDirect
Biological Process (BP)carboxylic acid catabolic process0.00000046260.0000000000001587InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process0.0000012190.0001245InformativeDirect
Biological Process (BP)regulation of cellular component movement0.000000000970.0004332InformativeDirect
Biological Process (BP)carbohydrate derivative catabolic process0.000000000000084870InformativeDirect
Biological Process (BP)regulation of cell cycle0.000000053041InformativeInherited
Biological Process (BP)positive regulation of developmental process0.000000017690.1358InformativeInherited
Biological Process (BP)positive regulation of cellular component organization0.0000000095181InformativeInherited
Biological Process (BP)regulation of cellular component biogenesis0.000000000079340.7455InformativeInherited
Biological Process (BP)regulation of cell proliferation0.0000016381InformativeInherited
Biological Process (BP)lipid catabolic process0.9820.674InformativeInherited
Biological Process (BP)membrane lipid metabolic process0.060450.0000000000001218InformativeInherited
Biological Process (BP)regulation of growth0.0000000024780.003517InformativeInherited
Biological Process (BP)regulation of locomotion0.0000000029890.002244InformativeInherited
Biological Process (BP)response to radiation0.0000033880.02715InformativeInherited
Biological Process (BP)liposaccharide metabolic process0.60420.000003911InformativeInherited
Biological Process (BP)cell death0.19991InformativeInherited
Biological Process (BP)polysaccharide catabolic process0.000000000023870Highly InformativeDirect
Biological Process (BP)regulation of cell growth0.000000000000019240.000000003408Highly InformativeDirect
Biological Process (BP)aminoglycan biosynthetic process00.000008635Highly InformativeDirect
Biological Process (BP)aminoglycan catabolic process00Highly InformativeDirect
Biological Process (BP)ceramide metabolic process0.00032550Highly InformativeDirect
Biological Process (BP)inflammatory response0.0000013140.000000000000003734Highly InformativeDirect
Biological Process (BP)oligosaccharide catabolic process0.00000077630Highly InformativeDirect
Biological Process (BP)response to UV0.000000000096730Highly InformativeDirect
Biological Process (BP)response to virus0.00000082250.00000000001295Highly InformativeDirect
Biological Process (BP)regulation of epithelial cell migration00.0000212Highly InformativeDirect
Biological Process (BP)cell wall biogenesis0.000022330.00000000003685Highly InformativeDirect
Biological Process (BP)response to estrogen0.0000510.00009503Highly InformativeDirect
Biological Process (BP)cell wall macromolecule metabolic process00Highly InformativeDirect
Biological Process (BP)cellular carbohydrate catabolic process0.00000012780Highly InformativeDirect
Biological Process (BP)multi-organism cellular process0.0000031510.000000000000003734Highly InformativeDirect
Biological Process (BP)positive regulation of angiogenesis00Highly InformativeDirect
Biological Process (BP)negative regulation of growth0.000000000000070030.000000000001305Highly InformativeDirect
Biological Process (BP)positive regulation of mitotic cell cycle00.000001539Highly InformativeDirect
Biological Process (BP)response to antibiotic00.0000000000005078Highly InformativeDirect
Biological Process (BP)cellular component macromolecule biosynthetic process0.0006220.0001218Highly InformativeDirect
Biological Process (BP)response to growth factor00.000000000122Highly InformativeDirect
Biological Process (BP)cellular response to abiotic stimulus00Highly InformativeDirect
Biological Process (BP)positive regulation of cell cycle process0.0000000000000016250.000229Highly InformativeDirect
Biological Process (BP)regulation of mitotic cell cycle phase transition0.000000000000042880.002763Highly InformativeInherited
Biological Process (BP)amino sugar metabolic process0.0062360.00000000000001763Highly InformativeInherited
Biological Process (BP)positive regulation of cellular component biogenesis0.0000000000000016250.04087Highly InformativeInherited
Biological Process (BP)regulation of epithelial cell proliferation00.002185Highly InformativeInherited
Biological Process (BP)glycosphingolipid metabolic process0.0016070.00000008014Highly InformativeInherited
Biological Process (BP)positive regulation of growth00.01701Highly InformativeInherited
Biological Process (BP)glycosaminoglycan metabolic process11Highly InformativeInherited
Biological Process (BP)positive regulation of cell migration0.000000000000024881Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)transferase activity, transferring glycosyl groups0.00000040370InformativeDirect
Molecular Function (MF)hydrolase activity, acting on glycosyl bonds00InformativeDirect
Molecular Function (MF)molecular transducer activity0.000000046640.4732InformativeInherited
Molecular Function (MF)hydrolase activity, hydrolyzing O-glycosyl compounds0.000000000056370Highly InformativeDirect
Molecular Function (MF)peptidoglycan muralytic activity0.00013180.0001939Highly InformativeDirect
Molecular Function (MF)UDP-glycosyltransferase activity0.000039461Highly InformativeInherited
Molecular Function (MF)transferase activity, transferring hexosyl groups0.0057510.00001049Highly InformativeInherited
Cellular Component (CC)membrane11Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)vacuole0.00000000010910Moderately InformativeDirect
Cellular Component (CC)vesicle0.00089020.0006306Moderately InformativeDirect
Cellular Component (CC)extracellular region part0.00043570Moderately InformativeDirect
Cellular Component (CC)plasma membrane11Moderately InformativeInherited
Cellular Component (CC)intrinsic component of membrane0.045880.01783Moderately InformativeInherited
Cellular Component (CC)cell surface0.000073070.00002569InformativeDirect
Cellular Component (CC)external encapsulating structure0.0000000032310InformativeDirect
Cellular Component (CC)lytic vacuole0.026730.00002642InformativeInherited
Cellular Component (CC)anchored component of membrane0.0000000000023350Highly InformativeDirect
Cellular Component (CC)intrinsic component of plasma membrane0.039160.001162Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.005748 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) generation of precursor metabolites and energy 0.0000001953 Moderately Informative Direct
Biological Process (BP) defense response 0.0000004896 Moderately Informative Direct
Biological Process (BP) response to biotic stimulus 0.0000007083 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.00009983 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.0007782 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.8826 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.1384 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.01331 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.2804 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.4107 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.01283 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) animal organ development 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.3112 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.1933 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.4852 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.3978 Moderately Informative Inherited
Biological Process (BP) cell activation 0.00005255 Informative Direct
Biological Process (BP) regulation of cytokine production 0.0007718 Informative Direct
Biological Process (BP) polysaccharide metabolic process 0 Informative Direct
Biological Process (BP) membrane lipid metabolic process 0.0000000000001218 Informative Direct
Biological Process (BP) response to oxidative stress 0.00000002156 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.00000000001442 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0004181 Informative Direct
Biological Process (BP) secretion by cell 0.00001181 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0 Informative Direct
Biological Process (BP) interspecies interaction between organisms 0.0006886 Informative Direct
Biological Process (BP) carboxylic acid catabolic process 0.0000000000001587 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.0001245 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0004332 Informative Direct
Biological Process (BP) regulation of transferase activity 0.000001474 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0 Informative Direct
Biological Process (BP) liposaccharide metabolic process 0.000003911 Informative Direct
Biological Process (BP) positive regulation of transport 0.2595 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.02824 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.1358 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.03902 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.7455 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.1058 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.05464 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.915 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) anion transport 0.6513 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.8069 Informative Inherited
Biological Process (BP) regulation of protein localization 0.1699 Informative Inherited
Biological Process (BP) regulation of defense response 0.05493 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.2161 Informative Inherited
Biological Process (BP) regulation of secretion 0.02641 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) protein transport 0.4809 Informative Inherited
Biological Process (BP) regulation of growth 0.003517 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.02181 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.07965 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.8998 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) multi-organism reproductive process 1 Informative Inherited
Biological Process (BP) glycosyl compound metabolic process 0.1034 Informative Inherited
Biological Process (BP) secondary metabolic process 0.9605 Informative Inherited
Biological Process (BP) lipid catabolic process 0.674 Informative Inherited
Biological Process (BP) organic acid transport 0.02117 Informative Inherited
Biological Process (BP) regulation of locomotion 0.002244 Informative Inherited
Biological Process (BP) response to radiation 0.02715 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) pigment metabolic process 0.3386 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 1 Informative Inherited
Biological Process (BP) immune effector process 0.3724 Informative Inherited
Biological Process (BP) immune response 0.6629 Informative Inherited
Biological Process (BP) cell death 1 Informative Inherited
Biological Process (BP) polysaccharide catabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of cell growth 0.000000003408 Highly Informative Direct
Biological Process (BP) positive regulation of cytokine production 0.0004122 Highly Informative Direct
Biological Process (BP) neutrophil mediated immunity 0.00002567 Highly Informative Direct
Biological Process (BP) positive regulation of peptide secretion 0.000000006407 Highly Informative Direct
Biological Process (BP) aminoglycan biosynthetic process 0.000008635 Highly Informative Direct
Biological Process (BP) aminoglycan catabolic process 0 Highly Informative Direct
Biological Process (BP) amino sugar metabolic process 0.00000000000001763 Highly Informative Direct
Biological Process (BP) energy reserve metabolic process 0 Highly Informative Direct
Biological Process (BP) ceramide metabolic process 0 Highly Informative Direct
Biological Process (BP) glycosphingolipid metabolic process 0.00000008014 Highly Informative Direct
Biological Process (BP) amino acid transport 0.00008169 Highly Informative Direct
Biological Process (BP) inflammatory response 0.000000000000003734 Highly Informative Direct
Biological Process (BP) digestion 0.0003946 Highly Informative Direct
Biological Process (BP) glycoprotein metabolic process 0.00000238 Highly Informative Direct
Biological Process (BP) protein secretion 0.00000002345 Highly Informative Direct
Biological Process (BP) oligosaccharide catabolic process 0 Highly Informative Direct
Biological Process (BP) response to UV 0 Highly Informative Direct
Biological Process (BP) response to mechanical stimulus 0.000003246 Highly Informative Direct
Biological Process (BP) response to virus 0.00000000001295 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell migration 0.0000212 Highly Informative Direct
Biological Process (BP) glycoside metabolic process 0.00001707 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.0002943 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0.0002527 Highly Informative Direct
Biological Process (BP) activation of protein kinase activity 0.000002437 Highly Informative Direct
Biological Process (BP) cellular polysaccharide biosynthetic process 0.0000000002285 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.0000189 Highly Informative Direct
Biological Process (BP) cell wall biogenesis 0.00000000003685 Highly Informative Direct
Biological Process (BP) leukocyte degranulation 0.00006019 Highly Informative Direct
Biological Process (BP) response to estrogen 0.00009503 Highly Informative Direct
Biological Process (BP) cell wall macromolecule metabolic process 0 Highly Informative Direct
Biological Process (BP) cellular carbohydrate catabolic process 0 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 0.000000000000003734 Highly Informative Direct
Biological Process (BP) positive regulation of angiogenesis 0 Highly Informative Direct
Biological Process (BP) negative regulation of growth 0.000000000001305 Highly Informative Direct
Biological Process (BP) positive regulation of mitotic cell cycle 0.000001539 Highly Informative Direct
Biological Process (BP) response to antibiotic 0.0000000000005078 Highly Informative Direct
Biological Process (BP) multicellular organismal homeostasis 0.00001931 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 0.000000000003341 Highly Informative Direct
Biological Process (BP) positive regulation of protein transport 0.00001182 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.000009008 Highly Informative Direct
Biological Process (BP) negative regulation of transferase activity 0.0001781 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0.0003762 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase B signaling 0.00000000002029 Highly Informative Direct
Biological Process (BP) cellular component macromolecule biosynthetic process 0.0001218 Highly Informative Direct
Biological Process (BP) response to growth factor 0.000000000122 Highly Informative Direct
Biological Process (BP) cellular response to abiotic stimulus 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 0.000229 Highly Informative Direct
Biological Process (BP) positive regulation of secretion by cell 0.000001952 Highly Informative Direct
Biological Process (BP) regulation of mitotic cell cycle phase transition 0.002763 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 0.04087 Highly Informative Inherited
Biological Process (BP) meiotic cell cycle 0.7145 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.07164 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.003221 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell proliferation 0.002185 Highly Informative Inherited
Biological Process (BP) pigmentation 0.1643 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphate metabolic process 0.01235 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 0.2047 Highly Informative Inherited
Biological Process (BP) myeloid cell activation involved in immune response 1 Highly Informative Inherited
Biological Process (BP) viral process 0.1454 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.482 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.01701 Highly Informative Inherited
Biological Process (BP) glycosaminoglycan metabolic process 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 1 Highly Informative Inherited
Biological Process (BP) fertilization 0.003508 Highly Informative Inherited
Biological Process (BP) positive regulation of protein serine/threonine kinase activity 0.72 Highly Informative Inherited
Biological Process (BP) granulocyte activation 1 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.0000006501 Moderately Informative Direct
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 1 Moderately Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.00005388 Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.0000004463 Informative Direct
Molecular Function (MF) receptor binding 0.7089 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.4732 Informative Inherited
Molecular Function (MF) hydrolase activity, hydrolyzing O-glycosyl compounds 0 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.00001049 Highly Informative Direct
Molecular Function (MF) kinase regulator activity 0.000000009872 Highly Informative Direct
Molecular Function (MF) peptidoglycan muralytic activity 0.0001939 Highly Informative Direct
Molecular Function (MF) UDP-glycosyltransferase activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) vacuole 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0006306 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.01638 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.1496 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.01783 Moderately Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) lytic vacuole 0.00002642 Informative Direct
Cellular Component (CC) cell surface 0.00002569 Informative Direct
Cellular Component (CC) secretory granule 0.0006229 Informative Direct
Cellular Component (CC) external encapsulating structure 0 Informative Direct
Cellular Component (CC) vacuolar part 0.000009753 Informative Direct
Cellular Component (CC) apical part of cell 0.0009246 Informative Direct
Cellular Component (CC) membrane region 0.0000001039 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0.6582 Informative Inherited
Cellular Component (CC) side of membrane 0.05526 Informative Inherited
Cellular Component (CC) plasma membrane region 0.2557 Informative Inherited
Cellular Component (CC) vacuolar lumen 0.00000000000002005 Highly Informative Direct
Cellular Component (CC) plant-type cell wall 0.0000936 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.00002357 Highly Informative Direct
Cellular Component (CC) anchored component of membrane 0 Highly Informative Direct
Cellular Component (CC) symplast 0.0000073 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle lumen 0.00009279 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.001162 Highly Informative Inherited
Cellular Component (CC) external side of plasma membrane 0.002054 Highly Informative Inherited
Cellular Component (CC) cell-cell junction 0.1363 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Beta-galactosidase0.00000000000005295InformativeDirect
Enzyme Commission (EC)1,4-alpha-glucan branching enzyme0Highly InformativeDirect
Enzyme Commission (EC)Beta-glucosidase2.368e-16Highly InformativeDirect
Enzyme Commission (EC)Cyclomaltodextrin glucanotransferase0.000000001012Highly InformativeDirect
Enzyme Commission (EC)Alpha-amylase0.000000009899Highly InformativeDirect
Enzyme Commission (EC)Alpha-glucosidase0.0004384Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processCell cycle0.00000998Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processPolysaccharide degradation0InformativeDirect
Biological processCell shape0InformativeDirect
Biological processPlant defense0InformativeDirect
Biological processCell wall biogenesis/degradation0InformativeDirect
Biological processInflammatory response0.000002785InformativeDirect
Biological processSphingolipid metabolism0Highly InformativeDirect
Biological processPeptidoglycan synthesis0Highly InformativeDirect
Biological processFertilization0.000004356Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentPlastid1Moderately InformativeInherited
Cellular componentGPI-anchor0InformativeDirect
Cellular componentLysosome0InformativeDirect
Cellular componentVacuole0.00000005365InformativeDirect
Cellular componentApoplast0Highly InformativeDirect
Cellular componentCell wall0.000001756Highly InformativeDirect
DiseaseGlycogen storage disease0.000000001024InformativeDirect
DiseaseDental caries0.0000000000002852Highly InformativeDirect
DiseaseMucopolysaccharidosis0.00000004115Highly InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor0.0000001296InformativeDirect
DomainEGF-like domain0.00001241InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionChloride0InformativeDirect
Molecular functionLectin0.0001058InformativeDirect
Molecular functionChitin-binding0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationGlycosyltransferase0InformativeDirect
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationAntimicrobial0.000000006782InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 161 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a (Trans)glycosidases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 161 hidden Markov models representing the (Trans)glycosidases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]