SUPERFAMILY 1.73 HMM library and genome assignments server


(Trans)glycosidases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (141)
  Mainly parallel beta sheets (beta-alpha-beta units)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
  contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
the first seven superfamilies have similar phosphate-binding sites
Superfamily:   (Trans)glycosidases [ 51445] (14)
Families:   Amylase, catalytic domain [ 51446] (24)
  members of the family may contain various insert subdomains
in alpha-amylases and closer relatives this domain is usually followed by a common all-beta domain
  beta-glycanases [ 51487] (24)
  consist of a number of sequence families
  Putative alpha-L-fucosidase, catalytic domain [ 102079]
  glycosyl hydrolase family 29; contains additional beta-barrel with a topological similarity to the C-terminal domain of alpha amylases
  Family 1 of glycosyl hydrolase [ 51521] (5)
  Type II chitinase [ 51534] (14)
  glycosylase family 18
  1,4-beta-N-acetylmuraminidase [ 63912] (3)
  Glycosyl hydrolase family 25; probably have evolved from a type II chitinase ancestor
permutation of the common fold; strand 8 is antiparallel to the rest of the barrel
  beta-N-acetylhexosaminidase catalytic domain [ 51550] (4)
  Glycosyl hydrolase family 20, GH20
  alpha-D-glucuronidase/Hyaluronidase catalytic domain [ 82253] (3)
  Glycosyl hydrolase family 67, GH67; structurally related to GH20; contains extra C-terminal alpha-helical subdomain
  NagZ-like [ 51553] (2)
  Pfam 00933; Glycosyl hydrolase family 3 domain
  Bee venom hyaluronidase [ 69387]
  distorted barrel lacks the second strand
  Outer surface protein, N-terminal domain [ 110354]
  corresponds to the N-terminal part of Pfam 05913
  YicI catalytic domain-like [ 117372] (2)
  Glycosyl hydrolases family 35 catalytic domain [ 117375]
  Pfam 01301
  TM1410-like [ 141796]
  Pfam 03537


Superfamily statistics
Genomes (1,277) UniProt 15.0 PDB chains (SCOP 1.73)
Domains 38,499 36,992 366
Proteins 37,770 36,471 366


Functional annotation
General category Metabolism
Detailed category Carbohydrate metabolism and transport

Function annotation of SCOP domain superfamilies

Jump to [ Top of page · SCOP classification · Functional annotation ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 157 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a (Trans)glycosidases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 157 hidden Markov models representing the (Trans)glycosidases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Internal database links ]