SUPERFAMILY 1.75 HMM library and genome assignments server

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PLC-like phosphodiesterases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   PLC-like phosphodiesterases [ 51695] (3)
Families:   Mammalian PLC [ 51696] (2)
  Bacterial PLC [ 51699]
  Glycerophosphoryl diester phosphodiesterase [ 89508] (4)


Superfamily statistics
Genomes (2,521) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 13,392 72,344 17
Proteins 12,912 71,210 17


Functional annotation
General category Processes_IC
Detailed category Phospholipid metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0.0000001001InformativeDirect
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.2146Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.857Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.00797InformativeInherited
Mammalian Phenotype (MP)abnormal ion homeostasis0.0114InformativeInherited
Mammalian Phenotype (MP)abnormal calcium ion homeostasis0.00008371Highly InformativeDirect
Mammalian Phenotype (MP)decreased platelet aggregation0.0000979Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.0137Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.04992Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.06518Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.06587Least InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.0001642Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.000459Moderately InformativeDirect
Worm Phenotype (WP)defecation variant0.00000003809InformativeDirect
Worm Phenotype (WP)cell stress response variant0.000001077InformativeDirect
Worm Phenotype (WP)oocyte morphology variant0.000004633InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.00001265InformativeDirect
Worm Phenotype (WP)gonad sheath contractions variant4.451e-16Highly InformativeDirect
Worm Phenotype (WP)osmotic stress response variant0.00000000000001065Highly InformativeDirect
Worm Phenotype (WP)ovulation variant0.00000000000004508Highly InformativeDirect
Worm Phenotype (WP)defecation contraction variant0.0000000000001243Highly InformativeDirect
Worm Phenotype (WP)endomitotic oocytes0.0000000000004146Highly InformativeDirect
Worm Phenotype (WP)RNAi response variant0.0000001727Highly InformativeDirect
Worm Phenotype (WP)post hermaphrodite contact variant0.00001538Highly InformativeDirect
Worm Phenotype (WP)male mating defective0.00002181Highly InformativeDirect
Worm Phenotype (WP)response to injury variant0.00006246Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect

Document: YP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage0.06851Moderately InformativeInherited
Xenopus DEvelopment stage (XDE)tailbud stage0.5737InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0InformativeDirect
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)Phosphoinositide phospholipase C0.00000003183Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a PLC-like phosphodiesterases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the PLC-like phosphodiesterases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]