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PLC-like phosphodiesterases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   PLC-like phosphodiesterases [ 51695] (3)
Families:   Mammalian PLC [ 51696] (2)
  Bacterial PLC [ 51699]
  Glycerophosphoryl diester phosphodiesterase [ 89508] (4)


Superfamily statistics
Genomes (2,521) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 13,392 56,176 17
Proteins 12,912 55,242 17


Functional annotation
General category Processes_IC
Detailed category Phospholipid metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.017050.000009093Least InformativeInherited
Biological Process (BP)primary metabolic process0.1641Least InformativeInherited
Biological Process (BP)single-organism cellular process0.03550.07234Least InformativeInherited
Biological Process (BP)lipid metabolic process0.000000076740Moderately InformativeDirect
Biological Process (BP)single-organism catabolic process0.0023740.01481Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.0022170.03728Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.0043480.07246Moderately InformativeInherited
Biological Process (BP)alcohol metabolic process0.00078770InformativeDirect
Biological Process (BP)phospholipid metabolic process00InformativeDirect
Biological Process (BP)lipid catabolic process0.0000038470.00000009164InformativeDirect
Biological Process (BP)organophosphate catabolic process0.0000002030.0000000001448InformativeDirect
Biological Process (BP)glycerolipid metabolic process0.056730.0000001278InformativeInherited
Biological Process (BP)phospholipid catabolic process0.000000031410.0000000008769Highly InformativeDirect
Biological Process (BP)glycerolipid catabolic process0.017620.0007765Highly InformativeInherited
Molecular Function (MF)hydrolase activity0.000000032830Least InformativeDirect
Molecular Function (MF)hydrolase activity, acting on ester bonds7.1e-160Moderately InformativeDirect
Molecular Function (MF)phosphoric diester hydrolase activity00Highly InformativeDirect
Molecular Function (MF)lipase activity0.000032830Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.000009093 Least Informative Direct
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.07234 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.5313 Least Informative Inherited
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0000001557 Moderately Informative Direct
Biological Process (BP) ion transport 0.01387 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.5755 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.4407 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.09996 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.5444 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.353 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.1432 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.03728 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.01481 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.07246 Moderately Informative Inherited
Biological Process (BP) organophosphate biosynthetic process 0.001672 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.5673 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.5753 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.3679 Moderately Informative Inherited
Biological Process (BP) reproduction 0.0247 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.3706 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.4349 Moderately Informative Inherited
Biological Process (BP) cell communication 0.0576 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.04919 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.2852 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) cell activation 0.0003003 Informative Direct
Biological Process (BP) alcohol metabolic process 0 Informative Direct
Biological Process (BP) phospholipid metabolic process 0 Informative Direct
Biological Process (BP) lipid catabolic process 0.00000009164 Informative Direct
Biological Process (BP) metal ion transport 0.00000381 Informative Direct
Biological Process (BP) regulation of locomotion 0.00006829 Informative Direct
Biological Process (BP) regulation of ion transport 0.0002729 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.0000000001448 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.0000001278 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0002813 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.0003481 Informative Direct
Biological Process (BP) transmembrane transport 0.0004189 Informative Direct
Biological Process (BP) inorganic ion homeostasis 0.000000007577 Informative Direct
Biological Process (BP) circulatory system development 0.1485 Informative Inherited
Biological Process (BP) response to wounding 0.04612 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.3193 Informative Inherited
Biological Process (BP) growth 0.02028 Informative Inherited
Biological Process (BP) hemopoiesis 0.002616 Informative Inherited
Biological Process (BP) regulation of system process 0.01283 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.01648 Informative Inherited
Biological Process (BP) single organism reproductive process 0.092 Informative Inherited
Biological Process (BP) cation homeostasis 0.714 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.8516 Informative Inherited
Biological Process (BP) regulation of immune response 0.06925 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.5391 Informative Inherited
Biological Process (BP) angiogenesis 0.0001114 Highly Informative Direct
Biological Process (BP) vasculogenesis 0.000001247 Highly Informative Direct
Biological Process (BP) leukocyte differentiation 0.0000008335 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0.000001179 Highly Informative Direct
Biological Process (BP) phospholipid catabolic process 0.0000000008769 Highly Informative Direct
Biological Process (BP) fertilization 0.0000000003869 Highly Informative Direct
Biological Process (BP) myeloid cell differentiation 0.0002091 Highly Informative Direct
Biological Process (BP) regeneration 0.0008805 Highly Informative Direct
Biological Process (BP) negative regulation of homeostatic process 0.00000000000136 Highly Informative Direct
Biological Process (BP) glycerolipid catabolic process 0.0007765 Highly Informative Direct
Biological Process (BP) divalent inorganic cation transport 0.0000000006749 Highly Informative Direct
Biological Process (BP) inorganic cation transmembrane transport 0.00000006296 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0.000000000002462 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0.001867 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 0.003533 Highly Informative Inherited
Biological Process (BP) wound healing 0.006521 Highly Informative Inherited
Biological Process (BP) kidney development 0.01982 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.9245 Moderately Informative Inherited
Molecular Function (MF) phospholipid binding 0.006624 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.3387 Informative Inherited
Molecular Function (MF) phosphoric diester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) lipase activity 0 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol phosphate binding 0.000397 Highly Informative Direct
Cellular Component (CC) membrane 0.04307 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.632 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 1 Moderately Informative Inherited
Cellular Component (CC) anchored component of membrane 0.00000005603 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0.0000001001InformativeDirect
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processVirulence0.00000313Moderately InformativeDirect
Biological processCytolysis0InformativeDirect
Biological processLipid degradation0InformativeDirect
Biological processGlycerol metabolism0Highly InformativeDirect
Biological processHemolysis0Highly InformativeDirect
Biological processFertilization0.00000000001033Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
DomainSignal0.0000001146Least InformativeDirect
DomainSH2 domain0.00000001277InformativeDirect
DomainSH3 domain0.000007882InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionMagnesium0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationZymogen0.0004329InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a PLC-like phosphodiesterases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the PLC-like phosphodiesterases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]