SUPERFAMILY 1.75 HMM library and genome assignments server

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Mammalian PLC family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   PLC-like phosphodiesterases [ 51695] (3)
Family:   Mammalian PLC [ 51696] (2)


Family statistics
Genomes (463) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 2,764 8,219 3
Proteins 2,748 8,175 3


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.2056Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.5414Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.003635InformativeInherited
Mammalian Phenotype (MP)abnormal ion homeostasis0.004023InformativeInherited
Mammalian Phenotype (MP)abnormal calcium ion homeostasis0.00001559Highly InformativeDirect
Mammalian Phenotype (MP)decreased platelet aggregation0.00004051Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0Least InformativeDirect
Worm Phenotype (WP)organism stress response variant0Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0Moderately InformativeDirect
Worm Phenotype (WP)cell type morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.00113Moderately InformativeInherited
Worm Phenotype (WP)cell stress response variant0InformativeDirect
Worm Phenotype (WP)defecation variant0InformativeDirect
Worm Phenotype (WP)hermaphrodite physiology variant0InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0InformativeDirect
Worm Phenotype (WP)oocyte morphology variant0InformativeDirect
Worm Phenotype (WP)protein subcellular localization variant0.00008682InformativeDirect
Worm Phenotype (WP)defecation contraction variant0Highly InformativeDirect
Worm Phenotype (WP)ovulation variant0Highly InformativeDirect
Worm Phenotype (WP)endomitotic oocytes0Highly InformativeDirect
Worm Phenotype (WP)osmotic stress response variant0Highly InformativeDirect
Worm Phenotype (WP)response to injury variant0.00001389Highly InformativeDirect
Worm Phenotype (WP)male mating variant0.0000195Highly InformativeDirect

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage0.02651Moderately InformativeInherited
Xenopus DEvelopment stage (XDE)tailbud stage0.6398InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a PLC-like phosphodiesterases domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]