SUPERFAMILY 1.75 HMM library and genome assignments server

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UROD/MetE-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   UROD/MetE-like [ 51726] (2)
Families:   Uroporphyrinogen decarboxylase, UROD [ 51727]
  Cobalamin-independent methionine synthase [ 110384]


Superfamily statistics
Genomes (2,902) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 8,774 49,679 11
Proteins 6,937 41,520 10


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.00050420.00000008404Least InformativeDirect
Biological Process (BP)organonitrogen compound metabolic process0.00078640.00001009Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process0.000036810.02245Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process0.00060660.07633Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.047860.000085Least InformativeInherited
Biological Process (BP)single-organism cellular process0.2590.1803Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.000013910.01448Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.000014340.01299Least InformativeInherited
Biological Process (BP)cofactor metabolic process0.00000000077940.000000011Moderately InformativeDirect
Biological Process (BP)aromatic compound biosynthetic process0.0000027450.001668Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.000022670.00563Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.000012280.002675Moderately InformativeInherited
Biological Process (BP)tetrapyrrole metabolic process00.00000000000001079InformativeDirect
Biological Process (BP)pigment metabolic process0.000000000074250.00000003085InformativeDirect
Biological Process (BP)heme biosynthetic process0.00000000022350.00000009669Highly InformativeDirect
Molecular Function (MF)lyase activity0.00000000044230.0000004638Moderately InformativeDirect
Molecular Function (MF)carbon-carbon lyase activity0.0000000000000079790.00000000000001973InformativeDirect
Molecular Function (MF)carboxy-lyase activity00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0.00000008404 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.000085 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.00001009 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.02245 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.07633 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.1803 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.01448 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.01299 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.0000004883 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0.0000004401 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.0006209 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.000000011 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.001668 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.00563 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.002675 Moderately Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.00001971 Informative Direct
Biological Process (BP) tetrapyrrole metabolic process 0.00000000000001079 Informative Direct
Biological Process (BP) pigment metabolic process 0.00000003085 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0.000001215 Informative Direct
Biological Process (BP) alpha-amino acid biosynthetic process 0.00101 Informative Inherited
Biological Process (BP) heme biosynthetic process 0.00000009669 Highly Informative Direct
Molecular Function (MF) transferase activity 0.01748 Least Informative Inherited
Molecular Function (MF) lyase activity 0.0000004638 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring one-carbon groups 0 Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 0.00000000000001973 Informative Direct
Molecular Function (MF) carboxy-lyase activity 0 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.8199 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.01471 Least Informative Inherited
Cellular Component (CC) plastid 0.000009311 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups0Least InformativeDirect
Enzyme Commission (EC)Methyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Carboxy-lyases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processMethionine biosynthesis0Highly InformativeDirect
Biological processPorphyrin biosynthesis0Highly InformativeDirect
Biological processMethanogenesis0.0000004682Highly InformativeDirect
Biological processHeme biosynthesis0.00000276Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainRepeat0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionMetal-binding0.00000000000001118Least InformativeDirect
Post-translational modificationTransferase0.000000000000006495Least InformativeDirect
Post-translational modificationLyase0Moderately InformativeDirect
Post-translational modificationMethyltransferase0InformativeDirect
Post-translational modificationDecarboxylase0Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a UROD/MetE-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the UROD/MetE-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]