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FAD/NAD(P)-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   FAD/NAD(P)-binding domain [ 51904]
Superfamily:   FAD/NAD(P)-binding domain [ 51905] (8)
Families:   C-terminal domain of adrenodoxin reductase-like [ 51906] (5)
  FAD-linked reductases, N-terminal domain [ 51913] (18)
  GDI-like N domain [ 51931] (2)
  Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain [ 51934] (5)
  FAD/NAD-linked reductases, N-terminal and central domains [ 51943] (15)
  Thi4-like [ 141942]
  GidA-like [ 141946]
  HI0933 N-terminal domain-like [ 159436] (2)


Superfamily statistics
Genomes (3,261) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 142,279 1,022,522 171
Proteins 127,014 925,947 156


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Methyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.0000000000001853Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.9013Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-NH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0InformativeDirect
Enzyme Commission (EC)With other acceptors7.054e-16InformativeDirect
Enzyme Commission (EC)Intramolecular lyases1InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related c0.7028InformativeInherited
Enzyme Commission (EC)Aldehyde-lyases0.7665InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.4281InformativeInherited
Enzyme Commission (EC)With other acceptors1InformativeInherited
Enzyme Commission (EC)With oxygen as acceptor0.01735InformativeInherited
Enzyme Commission (EC)Oxidizing metal ions0.117InformativeInherited
Enzyme Commission (EC)Miscellaneous (requires further characterization)1InformativeInherited
Enzyme Commission (EC)Acting on single donors with incorporation of mole1InformativeInherited
Enzyme Commission (EC)With a quinone or similar compound as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)tRNA (5-methylaminomethyl-2-thiouridylate)-methylt0Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With other acceptors0Highly InformativeDirect
Enzyme Commission (EC)Mercury(II) reductase0Highly InformativeDirect
Enzyme Commission (EC)L-aspartate oxidase2.368e-16Highly InformativeDirect
Enzyme Commission (EC)With a quinone or similar compound as acceptor7.054e-16Highly InformativeDirect
Enzyme Commission (EC)Succinate dehydrogenase (ubiquinone)0.00000000000724Highly InformativeDirect
Enzyme Commission (EC)Nitrite reductase (NAD(P)H)0.00000000003923Highly InformativeDirect
Enzyme Commission (EC)With incorporation of one atom of oxygen0.000000007326Highly InformativeDirect
Enzyme Commission (EC)With a flavin as acceptor0.00002146Highly InformativeDirect
Enzyme Commission (EC)Succinate dehydrogenase0.0001822Highly InformativeDirect
Enzyme Commission (EC)With other, known, acceptors0.08055Highly InformativeInherited
Enzyme Commission (EC)With oxygen as acceptor0.4925Highly InformativeInherited

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.02251Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.328Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.7908Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of acid-base homeostasis0.003539Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.4932Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of mitochondrial metabolism0.0009845InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the glial cells0.001196InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.7729Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.7951Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.8681Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.6986Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell morphology0.7089Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal catecholamine level0.01797Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.129Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.4652Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.5976Least InformativeInherited
Worm Phenotype (WP)life span variant0.0000001648Moderately InformativeDirect
Worm Phenotype (WP)pesticide response variant0.0003091InformativeDirect
Worm Phenotype (WP)egg laying variant0.1209InformativeInherited
Worm Phenotype (WP)fewer eggs laid0.000003131Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors0.9697Moderately InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors0.00000001294InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0.9863InformativeInherited
Enzyme Commission (EC)Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated1InformativeInherited
Enzyme Commission (EC)Acting on CH or CH(2) groups1InformativeInherited
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors1InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Acting on the CH-NH group of donors1InformativeInherited
Enzyme Commission (EC)Acting on other nitrogenous compounds as donors1InformativeInherited
Enzyme Commission (EC)Intramolecular oxidoreductases1InformativeInherited
Enzyme Commission (EC)With a quinone or similar compound as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0Highly InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With a quinone or similar compound as acceptor0.00000000008091Highly InformativeDirect
Enzyme Commission (EC)With a quinone or related compound as acceptor0.0000000003001Highly InformativeDirect
Enzyme Commission (EC)With incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidase0.000000001136Highly InformativeDirect
Enzyme Commission (EC)NADH dehydrogenase0.0000002372Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.000008508Highly InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0.0006429Highly InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0.1549Highly InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.3845Highly InformativeInherited
Enzyme Commission (EC)Aldehyde-lyases0.6544Highly InformativeInherited
Enzyme Commission (EC)With oxygen as acceptor0.7189Highly InformativeInherited
Enzyme Commission (EC)Transposing C=C bonds0.8163Highly InformativeInherited
Enzyme Commission (EC)With an iron-sulfur protein as acceptor0.8653Highly InformativeInherited
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen1Highly InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Highly InformativeInherited
Enzyme Commission (EC)With oxygen as acceptor1Highly InformativeInherited
Enzyme Commission (EC)Intramolecular lyases1Highly InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 99 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FAD/NAD(P)-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 99 hidden Markov models representing the FAD/NAD(P)-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]