SUPERFAMILY 1.73 HMM library and genome assignments server


FAD/NAD(P)-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (141)
  Mainly parallel beta sheets (beta-alpha-beta units)
Fold:   FAD/NAD(P)-binding domain [ 51904]
  core: 3 layers, b/b/a; central parallel beta-sheet of 5 strands, order 32145; top antiparallel beta-sheet of 3 strands, meander
Superfamily:   FAD/NAD(P)-binding domain [ 51905] (7)
Families:   C-terminal domain of adrenodoxin reductase-like [ 51906] (5)
  FAD-linked reductases, N-terminal domain [ 51913] (15)
  C-terminal domain is alpha+beta is common for the family
  GDI-like N domain [ 51931] (2)
  Similar to FAD-linked reductases in both domains but does not bind FAD
  Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain [ 51934] (5)
  FAD/NAD-linked reductases, N-terminal and central domains [ 51943] (15)
  duplication: both domains have similar folds and functions
most members of the family contain common C-terminal alpha+beta domain
  Thi4-like [ 141942]
  Pfam 01946; stand-alone, moderately decorated domain
  GidA-like [ 141946]
  part of Pfam 01266


Superfamily statistics
Genomes (1,373) UniProt 15.0 PDB chains (SCOP 1.73)
Domains 61,885 57,858 173
Proteins 54,860 52,055 139


Functional annotation
General category General
Detailed category Small molecule binding

Function annotation of SCOP domain superfamilies

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 93 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FAD/NAD(P)-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 93 hidden Markov models representing the FAD/NAD(P)-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Internal database links ]