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Phosphohistidine domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   The "swivelling" beta/beta/alpha domain [ 52008] (10)
Superfamily:   Phosphohistidine domain [ 52009] (2)
Families:   Pyruvate phosphate dikinase, central domain [ 52010]
  N-terminal domain of enzyme I of the PEP:sugar phosphotransferase system [ 52013]


Superfamily statistics
Genomes (2,754) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 6,609 40,424 12
Proteins 6,608 40,384 12


Functional annotation
General category Regulation
Detailed category Kinases/phosphatases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) primary metabolic process 0.78 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.004743 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.1122 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.000001937 Moderately Informative Direct
Biological Process (BP) single-organism transport 0.000000007601 Moderately Informative Direct
Biological Process (BP) organic substance transport 0.0000000001011 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.002491 Moderately Informative Inherited
Biological Process (BP) monosaccharide metabolic process 0.000001014 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.0000002084 Informative Direct
Biological Process (BP) glucose metabolic process 0.00000000001835 Highly Informative Direct
Biological Process (BP) phosphoenolpyruvate-dependent sugar phosphotransferase system 0.00000004425 Highly Informative Direct
Biological Process (BP) hexose biosynthetic process 0.0000000000002814 Highly Informative Direct
Molecular Function (MF) transferase activity 0.0000000000000402 Least Informative Direct
Molecular Function (MF) transporter activity 0.000004934 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.00001799 Moderately Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.9623 Informative Inherited
Molecular Function (MF) carbohydrate transmembrane transporter activity 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a nitrogenous group as ac0InformativeDirect
Enzyme Commission (EC)Pyruvate kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoenolpyruvate--protein phosphotransferase0Highly InformativeDirect
Enzyme Commission (EC)Pyruvate, phosphate dikinase0.000000008653Highly InformativeDirect
Enzyme Commission (EC)Pyruvate, water dikinase0.000000734Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processGlycolysis0.000000006652InformativeDirect
Biological processPhotosynthesis0.000001573InformativeDirect
Biological processSugar transport0Highly InformativeDirect
Biological processPhosphotransferase system0Highly InformativeDirect
Cellular componentCytoplasm0.000091Least InformativeDirect
DomainTransit peptide0.0002701Moderately InformativeDirect
Molecular functionMagnesium0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0.07446Least InformativeInherited
Molecular functionPotassium0.00000002747InformativeDirect
Molecular functionPyruvate0Highly InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0.000000008575Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008279 SSF52009 Protein matches
Abstract A number of enzymes that catalyze the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) via a phospho-histidine intermediate have been shown to be structurally related [PubMed7686067, PubMed8973315, PubMed2176881, PubMed1557039]. All these enzymes share the same catalytic mechanism: they bind PEP and transfer the phosphoryl group from it to a histidine residue. This domain is a "swivelling" beta/beta/alpha domain which is thought to be mobile in all proteins known to contain it [PubMed12083528]. It is often found associated with the pyruvate phosphate dikinase, PEP/pyruvate-binding domain at its N-terminus.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Phosphohistidine domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the Phosphohistidine domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]