SUPERFAMILY 1.75 HMM library and genome assignments server

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GroEL apical domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   The "swivelling" beta/beta/alpha domain [ 52008] (10)
Superfamily:   GroEL apical domain-like [ 52029] (2)
Families:   GroEL-like chaperone, apical domain [ 52030]
  Group II chaperonin (CCT, TRIC), apical domain [ 52034]


Superfamily statistics
Genomes (3,199) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 11,609 66,120 39
Proteins 11,593 66,024 39


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol-3-phosphate 5-kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the eye0.1757Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal posterior eye segment morphology0.1933Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal retinal morphology0.02648InformativeInherited
Phenotypic Abnormality (PA)Rod-cone dystrophy0.0001721Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.06825Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.1273Least InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.01053Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body composition0.2468Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.5344Moderately InformativeInherited
Mammalian Phenotype (MP)increased body weight0.0002438InformativeDirect
Mammalian Phenotype (MP)embryonic lethality prior to organogenesis0.002477InformativeInherited
Mammalian Phenotype (MP)embryonic lethality between implantation and placentation0.0005959Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0000002448Least InformativeDirect
Worm Phenotype (WP)cell development variant0.0000007304Least InformativeDirect
Worm Phenotype (WP)blast cell physiology variant0.000004176Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.000004192Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.00005897Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0002483Least InformativeDirect
Worm Phenotype (WP)germ cell differentiation variant0.00000000000633Moderately InformativeDirect
Worm Phenotype (WP)germ cell development variant0.000000001319Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.000000001454Moderately InformativeDirect
Worm Phenotype (WP)level of transgene expression variant0.00000001586Moderately InformativeDirect
Worm Phenotype (WP)protein protein interaction variant0.0000000194Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.0000000513Moderately InformativeDirect
Worm Phenotype (WP)apoptosis variant0.00000008926Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.0000001689Moderately InformativeDirect
Worm Phenotype (WP)feeding behavior variant0.0002756Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0.002532Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.002532Moderately InformativeInherited
Worm Phenotype (WP)developmental morphology variant0.002542Moderately InformativeInherited
Worm Phenotype (WP)adult body morphology variant0.002552Moderately InformativeInherited
Worm Phenotype (WP)body morphology variant0.002796Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.002815Moderately InformativeInherited
Worm Phenotype (WP)metabolic pathway variant0.005281Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.01039Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.024Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.1126Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.2296Moderately InformativeInherited
Worm Phenotype (WP)pleiotropic defects severe early emb0.000000000003451InformativeDirect
Worm Phenotype (WP)pachytene progression during oogenesis variant0.00000000001047InformativeDirect
Worm Phenotype (WP)transgene expression increased0.00000000007364InformativeDirect
Worm Phenotype (WP)germ cell compartment expansion variant0.0000000001689InformativeDirect
Worm Phenotype (WP)oocyte morphology variant0.000000004481InformativeDirect
Worm Phenotype (WP)avoids bacterial lawn0.00000002088InformativeDirect
Worm Phenotype (WP)endocytic transport defect0.000000213InformativeDirect
Worm Phenotype (WP)accumulated germline cell corpses0.0000002561InformativeDirect
Worm Phenotype (WP)vesicle morphology variant0.0000002735InformativeDirect
Worm Phenotype (WP)pigmentation variant0.0000009954InformativeDirect
Worm Phenotype (WP)protruding vulva0.000001761InformativeDirect
Worm Phenotype (WP)cell stress response variant0.000002803InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.000006383InformativeDirect
Worm Phenotype (WP)somatic gonad development variant0.0000256InformativeDirect
Worm Phenotype (WP)nuclear positioning variant0.00003244InformativeDirect
Worm Phenotype (WP)sick0.0004288InformativeDirect
Worm Phenotype (WP)life span variant0.0008943InformativeDirect
Worm Phenotype (WP)oocyte physiology variant0.0009809InformativeDirect
Worm Phenotype (WP)cell component localization variant0.00624InformativeInherited
Worm Phenotype (WP)mitosis variant0.09426InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.2252InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.2466InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.568InformativeInherited
Worm Phenotype (WP)oocytes small0.0000000000000177Highly InformativeDirect
Worm Phenotype (WP)unfolded protein response variant0.0000000002939Highly InformativeDirect
Worm Phenotype (WP)RAB-11 recycling endosome localization variant0.00000001597Highly InformativeDirect
Worm Phenotype (WP)germ cell compartment anucleate0.0000000729Highly InformativeDirect
Worm Phenotype (WP)male somatic gonad development variant0.0000006121Highly InformativeDirect
Worm Phenotype (WP)gonad arm morphology variant0.000001237Highly InformativeDirect
Worm Phenotype (WP)no oocytes0.000006256Highly InformativeDirect
Worm Phenotype (WP)chromosome condensation variant0.0000554Highly InformativeDirect
Worm Phenotype (WP)no induction of antimicrobial peptide expression after infection0.000106Highly InformativeDirect
Worm Phenotype (WP)cell membrane organization biogenesis variant0.0004285Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)chromosome/plasmid maintenance0.0004977InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0.4532Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)adult heart0.000000001601InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.6334Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.02505Moderately InformativeInherited
Zebrafish Anatomy (ZA)electrically active cell0.06183Moderately InformativeInherited
Zebrafish Anatomy (ZA)skeletal muscle0.00004603InformativeDirect
Zebrafish Anatomy (ZA)muscle cell0.0003764InformativeDirect
Zebrafish Anatomy (ZA)myotome0.000004227Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.1272Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.3237Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.002168Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.01325Moderately InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.00001925InformativeDirect
Xenopus ANatomical entity (XAN)immune system0.0006014InformativeDirect
Xenopus ANatomical entity (XAN)dermal system0.0006292InformativeDirect
Xenopus ANatomical entity (XAN)endocrine system0.001043InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.006871InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.02532InformativeInherited
Xenopus ANatomical entity (XAN)anterior dorsal lateral plate region0.0003994Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0.0002759Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0.001989Least InformativeInherited
Plant ANatomical entity (PAN)sporangium0.009725Least InformativeInherited
Plant ANatomical entity (PAN)pollen0.0005692Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.00000002354InformativeDirect
Plant structure DEvelopment stage (PDE)0 seed germination stage0.0004208InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0.000006833Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.000000000001877Moderately InformativeDirect
Enzyme Commission (EC)Isomerases0.000007182Moderately InformativeDirect
Enzyme Commission (EC)Isomerases altering macromolecular conformation5.087e-16InformativeDirect
Enzyme Commission (EC)Enzymes altering polypeptide conformation or assembly0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GroEL apical domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the GroEL apical domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]