SUPERFAMILY 1.75 HMM library and genome assignments server

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GroEL apical domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   The "swivelling" beta/beta/alpha domain [ 52008] (10)
Superfamily:   GroEL apical domain-like [ 52029] (2)
Families:   GroEL-like chaperone, apical domain [ 52030]
  Group II chaperonin (CCT, TRIC), apical domain [ 52034]


Superfamily statistics
Genomes (3,199) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 11,609 66,120 39
Proteins 11,593 66,024 39


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol-3-phosphate 5-kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the eye0.1474Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal globe morphology0.06965Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal retinal morphology0.02344InformativeInherited
Phenotypic Abnormality (PA)Rod-cone dystrophy0.0001732Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.06822Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.1269Least InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.01051Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body composition0.2471Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.5346Moderately InformativeInherited
Mammalian Phenotype (MP)increased body weight0.0002439InformativeDirect
Mammalian Phenotype (MP)embryonic lethality prior to organogenesis0.002461InformativeInherited
Mammalian Phenotype (MP)embryonic lethality between implantation and placentation0.0005971Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0000001962Least InformativeDirect
Worm Phenotype (WP)cell development variant0.0000005356Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.000002409Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.00004305Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.00006932Least InformativeDirect
Worm Phenotype (WP)gametogenesis variant0.0000000007914Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.000000001451Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.000000001518Moderately InformativeDirect
Worm Phenotype (WP)protein protein interaction variant0.00000002151Moderately InformativeDirect
Worm Phenotype (WP)apoptosis variant0.00000008579Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.0000001815Moderately InformativeDirect
Worm Phenotype (WP)life span variant0.00003639Moderately InformativeDirect
Worm Phenotype (WP)feeding behavior variant0.0006957Moderately InformativeDirect
Worm Phenotype (WP)metabolic pathway variant0.001255Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.007412Moderately InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.06077Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.07174Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.1137Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.1413Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.1851Moderately InformativeInherited
Worm Phenotype (WP)pleiotropic defects severe early emb0.00000000000386InformativeDirect
Worm Phenotype (WP)pachytene progression during oogenesis variant0.00000000000929InformativeDirect
Worm Phenotype (WP)germ cell compartment expansion variant0.0000000001615InformativeDirect
Worm Phenotype (WP)oocyte morphology variant0.000000003844InformativeDirect
Worm Phenotype (WP)avoids bacterial lawn0.00000002261InformativeDirect
Worm Phenotype (WP)transgene expression increased0.0000002135InformativeDirect
Worm Phenotype (WP)endocytic transport defect0.000000224InformativeDirect
Worm Phenotype (WP)accumulated germline cell corpses0.0000002503InformativeDirect
Worm Phenotype (WP)pigmentation variant0.000001046InformativeDirect
Worm Phenotype (WP)protruding vulva0.000001786InformativeDirect
Worm Phenotype (WP)cell stress response variant0.00000186InformativeDirect
Worm Phenotype (WP)gonad development variant0.00006297InformativeDirect
Worm Phenotype (WP)sick0.0003789InformativeDirect
Worm Phenotype (WP)endosome morphology variant0.008278InformativeInherited
Worm Phenotype (WP)organelle organization biogenesis variant0.03538InformativeInherited
Worm Phenotype (WP)mitosis variant0.09155InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.2193InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.2514InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.7433InformativeInherited
Worm Phenotype (WP)oocytes small0.0000000000000146Highly InformativeDirect
Worm Phenotype (WP)unfolded protein response variant0.0000000000909Highly InformativeDirect
Worm Phenotype (WP)recycling endosome localization variant0.00000001624Highly InformativeDirect
Worm Phenotype (WP)germ cell compartment anucleate0.00000007121Highly InformativeDirect
Worm Phenotype (WP)male somatic gonad development variant0.0000006916Highly InformativeDirect
Worm Phenotype (WP)gonad arm morphology variant0.000001361Highly InformativeDirect
Worm Phenotype (WP)no oocytes0.000006965Highly InformativeDirect
Worm Phenotype (WP)chromosome condensation variant0.00005369Highly InformativeDirect
Worm Phenotype (WP)no induction of antimicrobial peptide expression after infection0.0001102Highly InformativeDirect
Worm Phenotype (WP)cell membrane organization biogenesis variant0.0004424Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)chromosome/plasmid maintenance0.0004891InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0.1219Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.6598Least InformativeInherited
Fly Anatomy (FA)adult heart0.00000009966InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.1068Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.2973Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.0007373Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.04398Moderately InformativeInherited
Xenopus ANatomical entity (XAN)skeletal muscle0.00001004InformativeDirect
Xenopus ANatomical entity (XAN)dermal system0.0004967InformativeDirect
Xenopus ANatomical entity (XAN)immune system0.0005636InformativeDirect
Xenopus ANatomical entity (XAN)endocrine system0.0009354InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.003988InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.01111InformativeInherited
Xenopus ANatomical entity (XAN)anterior dorsal lateral plate region0.000003657Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0.0002746Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0.00198Least InformativeInherited
Plant ANatomical entity (PAN)sporangium0.00967Least InformativeInherited
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.00000002358InformativeDirect
Plant structure DEvelopment stage (PDE)0 seed germination stage0.0004212InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0.000007206Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.02398Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.000000000001967Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.000003109Moderately InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GroEL apical domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the GroEL apical domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]