SUPERFAMILY 1.75 HMM library and genome assignments server

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GroEL apical domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   The "swivelling" beta/beta/alpha domain [ 52008] (10)
Superfamily:   GroEL apical domain-like [ 52029] (2)
Families:   GroEL-like chaperone, apical domain [ 52030]
  Group II chaperonin (CCT, TRIC), apical domain [ 52034]


Superfamily statistics
Genomes (3,199) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 11,609 66,120 39
Proteins 11,593 66,024 39


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)1-phosphatidylinositol-3-phosphate 5-kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the eye0.1501Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal globe morphology0.0693Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal retinal morphology0.02338InformativeInherited
Phenotypic Abnormality (PA)Rod-cone dystrophy0.0001655Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.06823Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.127Least InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.01053Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body composition0.2472Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.5347Moderately InformativeInherited
Mammalian Phenotype (MP)increased body weight0.0002438InformativeDirect
Mammalian Phenotype (MP)embryonic lethality prior to organogenesis0.002473InformativeInherited
Mammalian Phenotype (MP)embryonic lethality between implantation and placentation0.0005967Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0000001971Least InformativeDirect
Worm Phenotype (WP)cell development variant0.0000005576Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.000002378Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.00004319Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.00006958Least InformativeDirect
Worm Phenotype (WP)gametogenesis variant0.0000000007982Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.000000001439Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.000000001541Moderately InformativeDirect
Worm Phenotype (WP)protein protein interaction variant0.00000002085Moderately InformativeDirect
Worm Phenotype (WP)apoptosis variant0.00000008324Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.0000001714Moderately InformativeDirect
Worm Phenotype (WP)life span variant0.00003634Moderately InformativeDirect
Worm Phenotype (WP)feeding behavior variant0.0006851Moderately InformativeDirect
Worm Phenotype (WP)metabolic pathway variant0.001294Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.007442Moderately InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.06205Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.07294Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.1144Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.1365Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.1888Moderately InformativeInherited
Worm Phenotype (WP)pleiotropic defects severe early emb0.000000000003911InformativeDirect
Worm Phenotype (WP)pachytene progression during oogenesis variant0.000000000009426InformativeDirect
Worm Phenotype (WP)germ cell compartment expansion variant0.0000000001639InformativeDirect
Worm Phenotype (WP)oocyte morphology variant0.000000003899InformativeDirect
Worm Phenotype (WP)avoids bacterial lawn0.00000002199InformativeDirect
Worm Phenotype (WP)transgene expression increased0.0000002122InformativeDirect
Worm Phenotype (WP)endocytic transport defect0.0000002142InformativeDirect
Worm Phenotype (WP)accumulated germline cell corpses0.0000002529InformativeDirect
Worm Phenotype (WP)pigmentation variant0.0000009544InformativeDirect
Worm Phenotype (WP)protruding vulva0.000001772InformativeDirect
Worm Phenotype (WP)cell stress response variant0.000001909InformativeDirect
Worm Phenotype (WP)somatic gonad development variant0.00002516InformativeDirect
Worm Phenotype (WP)sick0.0004093InformativeDirect
Worm Phenotype (WP)endosome morphology variant0.00834InformativeInherited
Worm Phenotype (WP)organelle organization biogenesis variant0.03576InformativeInherited
Worm Phenotype (WP)mitosis variant0.09219InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.223InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.2507InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.7458InformativeInherited
Worm Phenotype (WP)oocytes small0.00000000000001463Highly InformativeDirect
Worm Phenotype (WP)unfolded protein response variant0.00000000009191Highly InformativeDirect
Worm Phenotype (WP)recycling endosome localization variant0.00000001642Highly InformativeDirect
Worm Phenotype (WP)germ cell compartment anucleate0.00000007188Highly InformativeDirect
Worm Phenotype (WP)male somatic gonad development variant0.0000006548Highly InformativeDirect
Worm Phenotype (WP)gonad arm morphology variant0.0000013Highly InformativeDirect
Worm Phenotype (WP)no oocytes0.000006619Highly InformativeDirect
Worm Phenotype (WP)chromosome condensation variant0.000054Highly InformativeDirect
Worm Phenotype (WP)no induction of antimicrobial peptide expression after infection0.000109Highly InformativeDirect
Worm Phenotype (WP)cell membrane organization biogenesis variant0.0004471Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)chromosome/plasmid maintenance0.0004891InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0.02902Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.444Least InformativeInherited
Fly Anatomy (FA)adult heart0.000000001428InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.1106Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.3029Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.0007527Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.04483Moderately InformativeInherited
Xenopus ANatomical entity (XAN)skeletal muscle0.00001007InformativeDirect
Xenopus ANatomical entity (XAN)dermal system0.0005035InformativeDirect
Xenopus ANatomical entity (XAN)immune system0.0005673InformativeDirect
Xenopus ANatomical entity (XAN)endocrine system0.0009495InformativeDirect
Xenopus ANatomical entity (XAN)lateral plate mesoderm0.001318InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.004261InformativeInherited
Xenopus ANatomical entity (XAN)anterior dorsal lateral plate region0.000004826Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0.0002746Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0.00198Least InformativeInherited
Plant ANatomical entity (PAN)sporangium0.00967Least InformativeInherited
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.00000002358InformativeDirect
Plant structure DEvelopment stage (PDE)0 seed germination stage0.0004212InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0.000007069Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.02465Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.000000000001929Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.000003016Moderately InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GroEL apical domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the GroEL apical domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]