SUPERFAMILY 1.75 HMM library and genome assignments server

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28-residue LRR family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [ 52046] (3)
Superfamily:   RNI-like [ 52047] (3)
Family:   28-residue LRR [ 52048] (2)


Family statistics
Genomes (130) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,754 3,594 8
Proteins 1,665 3,422 5


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)gastrointestinal system disease0.06306Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease0.000797InformativeDirect
Disease Ontology (DO)upper respiratory tract disease0.004181InformativeInherited
Disease Ontology (DO)Crohn's disease0.0001178Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the immune system0.03201Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.06842Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1203Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.2095Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.2538Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.31Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.4578Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.008808Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lymphatic system0.01656Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal homeostasis0.09923Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.09926Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.1752Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal ocular adnexa morphology0.1948Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.2015Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.2194Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.2257Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating metabolite concentration0.322Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system morphology0.3509Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.3991Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Fever0.0001932InformativeDirect
Phenotypic Abnormality (PA)Stomatitis0.0002InformativeDirect
Phenotypic Abnormality (PA)Unusual infection by anatomical site0.0004564InformativeDirect
Phenotypic Abnormality (PA)Splenomegaly0.0006682InformativeDirect
Phenotypic Abnormality (PA)Inflammatory abnormality of the eye0.00154InformativeInherited
Phenotypic Abnormality (PA)Abnormal uvea morphology0.001866InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating protein level0.01056InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lymph nodes0.0296InformativeInherited
Phenotypic Abnormality (PA)Pain0.03576InformativeInherited
Phenotypic Abnormality (PA)Abnormal intestine morphology0.0383InformativeInherited
Phenotypic Abnormality (PA)Abnormal leukocyte morphology0.04894InformativeInherited
Phenotypic Abnormality (PA)Functional abnormality of the gastrointestinal tract0.06574InformativeInherited
Phenotypic Abnormality (PA)Abnormal fundus morphology0.1379InformativeInherited
Phenotypic Abnormality (PA)Recurrent aphthous stomatitis0.0000006675Highly InformativeDirect
Phenotypic Abnormality (PA)Conjunctivitis0.00002186Highly InformativeDirect
Phenotypic Abnormality (PA)Leukocytosis0.00006132Highly InformativeDirect
Phenotypic Abnormality (PA)Uveitis0.00006384Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal erythrocyte sedimentation rate0.0001229Highly InformativeDirect
Phenotypic Abnormality (PA)Myalgia0.0001582Highly InformativeDirect
Phenotypic Abnormality (PA)Arthralgia0.0002442Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal C-reactive protein level0.0004726Highly InformativeDirect
Phenotypic Abnormality (PA)Photophobia0.0006514Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.002726Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.03939Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.2222Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.00008938Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte physiology0.0006265Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0.002653Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.2038Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.3Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal circulating interleukin level0.00009444InformativeDirect
Mammalian Phenotype (MP)abnormal digestive system physiology0.02514InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin-1 beta secretion0.00001188Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)slow growth0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)larval arrest0Least InformativeDirect
Worm Phenotype (WP)progeny variant0Least InformativeDirect

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0.34Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster0.5484Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.8798Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.2675Moderately InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.08246InformativeInherited
Xenopus ANatomical entity (XAN)trunk musculature0.0004291Highly InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0.009234Moderately InformativeInherited
Xenopus DEvelopment stage (XDE)neurula stage0.0001472Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 12 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a RNI-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]