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BRCT domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   BRCT domain [ 52112]
Superfamily:   BRCT domain [ 52113] (5)
Families:   BRCT domain [ 63955]
  53BP1 [ 75148]
  DNA-repair protein XRCC1 [ 52114]
  DNA ligase [ 52117] (2)
  DNA topoisomerase II binding protein 1, TopBP1 [ 117468]


Superfamily statistics
Genomes (3,049) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 16,988 67,938 22
Proteins 12,160 53,277 14


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases1Least InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0InformativeDirect
Enzyme Commission (EC)Ligases that form phosphoric-ester bonds1InformativeInherited
Enzyme Commission (EC)DNA nucleotidylexotransferase0Highly InformativeDirect
Enzyme Commission (EC)DNA ligase (NAD(+))0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)genetic disease0.0000001952Moderately InformativeDirect
Disease Ontology (DO)autosomal dominant disease0.00000000001371InformativeDirect
Disease Ontology (DO)hereditary breast ovarian cancer syndrome0.00000000000009498Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.06405Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.2539Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.4Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.4251Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.01789Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal ocular adnexa morphology0.01796Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0.05453Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.07254Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.1206Moderately InformativeInherited
Phenotypic Abnormality (PA)Gonadal neoplasm0.000979InformativeDirect
Phenotypic Abnormality (PA)Abnormal eyelid morphology0.008403InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the gastrointestinal tract0.01795InformativeInherited
Phenotypic Abnormality (PA)Abnormal breast morphology0.02296InformativeInherited
Phenotypic Abnormality (PA)Abnormal hair morphology0.0354InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the forehead0.07517InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ovary0.2785InformativeInherited
Phenotypic Abnormality (PA)Breast carcinoma0.0001442Highly InformativeDirect
Phenotypic Abnormality (PA)Ovarian neoplasm0.000315Highly InformativeDirect
Phenotypic Abnormality (PA)Long eyelashes0.0004627Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the frontal hairline0.003171Highly InformativeInherited
Phenotypic Abnormality (PA)Slanting of the palpebral fissure0.01704Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.01912Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.02296Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.06139Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.1041Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.1305Least InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.0000008922Moderately InformativeDirect
Mammalian Phenotype (MP)embryo phenotype0.0003248Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.004489Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.004493Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.01699Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.03966Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.04279Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.04849Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.2488Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.2746Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell morphology0.3088Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal DNA repair0.0000000003242InformativeDirect
Mammalian Phenotype (MP)chromosomal instability0.0000000005598InformativeDirect
Mammalian Phenotype (MP)embryonic lethality prior to organogenesis0.000001389InformativeDirect
Mammalian Phenotype (MP)abnormal response to radiation0.0002036InformativeDirect
Mammalian Phenotype (MP)increased apoptosis0.0004538InformativeDirect
Mammalian Phenotype (MP)increased gland tumor incidence0.002012InformativeInherited
Mammalian Phenotype (MP)abnormal sensitivity to induced morbidity/mortality0.002726InformativeInherited
Mammalian Phenotype (MP)abnormal prenatal growth/weight/body size0.002878InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.02942InformativeInherited
Mammalian Phenotype (MP)increased hemolymphoid system tumor incidence0.2157InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology0.3482InformativeInherited
Mammalian Phenotype (MP)increased mortality induced by ionizing radiation0.000000003037Highly InformativeDirect
Mammalian Phenotype (MP)increased sensitivity to induced cell death0.0000006206Highly InformativeDirect
Mammalian Phenotype (MP)abnormal immunoglobulin V(D)J recombination0.00006906Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cell cycle0.00007683Highly InformativeDirect
Mammalian Phenotype (MP)increased T cell derived lymphoma incidence0.0001713Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cell nucleus morphology0.004915Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)blast cell physiology variant0.4312Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.4318Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.9038Least InformativeInherited
Worm Phenotype (WP)organism stress response variant0.2225Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.6332Moderately InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)cell cycle progression0.0105InformativeInherited
Yeast Phenotype (YP)cell cycle progression in S phase0.0004444Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.07864Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.0005671InformativeDirect
Enzyme Commission (EC)Pentosyltransferases1InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Forming phosphoric ester bonds1Highly InformativeInherited

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR001357 SSF52113 Protein matches
Abstract

The BRCT domain (after the C_terminal domain of a breast cancer susceptibility protein) is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage [PubMed9034168], for example as found in the breast cancer DNA-repair protein BRCA1. The domain is an approximately 100 amino acid tandem repeat, which appears to act as a phospho-protein binding domain [PubMed14576433].

A chitin biosynthesis protein from yeast also seems to belong to this group.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 12 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a BRCT domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 12 hidden Markov models representing the BRCT domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]