SUPERFAMILY 1.75 HMM library and genome assignments server

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Caspase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Caspase-like [ 52128]
Superfamily:   Caspase-like [ 52129] (2)
Families:   Caspase catalytic domain [ 52130] (7)
  Gingipain R (RgpB), N-terminal domain [ 52137]


Superfamily statistics
Genomes (975) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 4,641 26,093 38
Proteins 4,558 25,794 38


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)cell type cancer0.06396Moderately InformativeInherited
Disease Ontology (DO)melanoma0.0009327Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the integument0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1769Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.064Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lymphatic system0.004388InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lymph nodes0.0001438Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.001994Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.003611Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.01045Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.01072Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.1016Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.8572Least InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.000001151Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte physiology0.00002697Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.02518Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.05225Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.08873Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.1823Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.513Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.5467Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.00000003566InformativeDirect
Mammalian Phenotype (MP)abnormal neuron physiology0.00001869InformativeDirect
Mammalian Phenotype (MP)abnormal gland physiology0.00169InformativeInherited
Mammalian Phenotype (MP)abnormal physiological response to xenobiotic0.002799InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.004537InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level0.006465InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to bacterial infection0.01048InformativeInherited
Mammalian Phenotype (MP)abnormal circulating cytokine level0.05531InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology0.1212InformativeInherited
Mammalian Phenotype (MP)abnormal macrophage physiology0.2155InformativeInherited
Mammalian Phenotype (MP)abnormal sensitivity to induced morbidity/mortality0.5518InformativeInherited
Mammalian Phenotype (MP)abnormal circulating interleukin-18 level0.000001071Highly InformativeDirect
Mammalian Phenotype (MP)abnormal immune organ physiology0.000004508Highly InformativeDirect
Mammalian Phenotype (MP)decreased sensitivity to induced cell death0.000005853Highly InformativeDirect
Mammalian Phenotype (MP)abnormal T cell apoptosis0.00001871Highly InformativeDirect
Mammalian Phenotype (MP)decreased physiological sensitivity to xenobiotic0.0000425Highly InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin-1 beta secretion0.0001401Highly InformativeDirect
Mammalian Phenotype (MP)decreased apoptosis0.0001402Highly InformativeDirect
Mammalian Phenotype (MP)abnormal macrophage apoptosis0.00044Highly InformativeDirect
Mammalian Phenotype (MP)abnormal neuron apoptosis0.0004476Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spleen marginal zone morphology0.0009537Highly InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to infection induced morbidity/mortality0.0123Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.03479Least InformativeInherited
Worm Phenotype (WP)somatic cell death variant0.00000000003014Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell death defective0.00008248Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)nervous system0.05867Least InformativeInherited
Fly Anatomy (FA)organism subdivision0.1072Least InformativeInherited
Fly Anatomy (FA)adult0.1378Least InformativeInherited
Fly Anatomy (FA)cell0.4683Least InformativeInherited
Fly Anatomy (FA)larva0.58Least InformativeInherited
Fly Anatomy (FA)head0.01223Moderately InformativeInherited
Fly Anatomy (FA)sensory system0.01955Moderately InformativeInherited
Fly Anatomy (FA)adult tagma0.04284Moderately InformativeInherited
Fly Anatomy (FA)neuron0.05345Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.0678Moderately InformativeInherited
Fly Anatomy (FA)male-specific anatomical entity0.0002041InformativeDirect
Fly Anatomy (FA)peptidergic neuron0.000003116Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)anatomical cluster0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)pollen0Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Caspase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the Caspase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]