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N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Flavodoxin-like [ 52171] (15)
Superfamily:   N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) [ 52255]
Families:   N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) [ 52256]


Superfamily statistics
Genomes (2,782) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 3,467 19,335 6
Proteins 3,455 19,285 6


Functional annotation
General category Metabolism
Detailed category Nucleotide metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.000005142 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.00001437 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.0003459 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.000004605 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.00001047 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.0002334 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0575 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.01986 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.005628 Least Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 0.0000000000000376 Moderately Informative Direct
Biological Process (BP) organophosphate biosynthetic process 0.00001407 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.002819 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 0.03322 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.001562 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.001078 Moderately Informative Inherited
Biological Process (BP) purine-containing compound biosynthetic process 0.0000007346 Informative Direct
Biological Process (BP) nucleobase metabolic process 0.00000000001073 Highly Informative Direct
Molecular Function (MF) lyase activity 0.000000000002285 Moderately Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 0 Informative Direct
Molecular Function (MF) carboxy-lyase activity 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Lyases0.000000004208Least InformativeDirect
Enzyme Commission (EC)Ligases0.1166Least InformativeInherited
Enzyme Commission (EC)Carboxy-lyases0Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds0.0002403Moderately InformativeDirect
Enzyme Commission (EC)Transferring other groups0InformativeDirect
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0.00000009136InformativeDirect
Enzyme Commission (EC)Phosphoribosylaminoimidazole carboxylase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processPurine biosynthesis0InformativeDirect
Molecular functionNucleotide-binding0.002352Least InformativeInherited
Post-translational modificationIsomerase0Moderately InformativeDirect
Post-translational modificationLyase0.00000000000003697Moderately InformativeDirect
Post-translational modificationDecarboxylase0.000000000000003271Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000031 SSF52255 Protein matches
Abstract

Phosphoribosylaminoimidazole carboxylase is a fusion protein in plants and fungi, but consists of two non-interacting proteins in bacteria, PurK and PurE. PurK, N5-carboxyaminoimidazole ribonucleotide (N5_CAIR) synthetase, catalyzes the conversion of 5-aminoimidazole ribonucleotide (AIR), ATP, and bicarbonate to N5-CAIR, ADP, and Pi. PurE converts N5-CAIR to CAIR, the sixth step of de novo purine biosynthesis. In the presence of high concentrations of bicarbonate, PurE is reported able to convert AIR to CAIR directly and without ATP. Some members of this family contain two copies of this domain [PubMed10074353]. The crystal structure of PurE indicates a unique quaternary structure that confirms the octameric nature of the enzyme [PubMed10574791].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]