SUPERFAMILY 1.75 HMM library and genome assignments server

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DJ-1/PfpI family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Flavodoxin-like [ 52171] (15)
Superfamily:   Class I glutamine amidotransferase-like [ 52317] (9)
Family:   DJ-1/PfpI [ 52325] (9)


Family statistics
Genomes (1,827) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 3,808 19,174 20
Proteins 3,713 19,023 20


Gene Ontology (high-quality)

(
show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biological regulation0.99781Least InformativeInherited
Biological Process (BP)biosynthetic process0.015030.01184Least InformativeInherited
Biological Process (BP)macromolecule metabolic process0.25950.9009Least InformativeInherited
Biological Process (BP)primary metabolic process0.80110.9972Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process0.27440.3522Least InformativeInherited
Biological Process (BP)single-organism cellular process0.31360.9275Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.02570.005007Least InformativeInherited
Biological Process (BP)response to stimulus0.12290.6324Least InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.00017190.00005305Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process0.000039560.000009957Moderately InformativeDirect
Biological Process (BP)regulation of cellular metabolic process0.086010.912Moderately InformativeInherited
Biological Process (BP)regulation of biosynthetic process0.012680.6293Moderately InformativeInherited
Biological Process (BP)cellular response to stimulus0.00030220.06202Moderately InformativeInherited
Biological Process (BP)negative regulation of biological process0.017980.5898Moderately InformativeInherited
Biological Process (BP)regulation of molecular function0.0027360.07077Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.039180.4343Moderately InformativeInherited
Biological Process (BP)macromolecule modification0.00082570.03645Moderately InformativeInherited
Biological Process (BP)response to chemical0.001910.008491Moderately InformativeInherited
Biological Process (BP)response to stress0.38850.3423Moderately InformativeInherited
Biological Process (BP)regulation of localization0.0087270.1267Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.018960.3007Moderately InformativeInherited
Biological Process (BP)single organism signaling0.022210.5168Moderately InformativeInherited
Biological Process (BP)cell communication0.00069290.136Moderately InformativeInherited
Biological Process (BP)transport0.37090.5944Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.0031570.03157Moderately InformativeInherited
Biological Process (BP)organelle organization0.094110.4422Moderately InformativeInherited
Biological Process (BP)cellular protein metabolic process0.0050820.1092Moderately InformativeInherited
Biological Process (BP)carboxylic acid metabolic process0.0013210.00003574Moderately InformativeInherited
Biological Process (BP)single-organism localization0.080430.1443Moderately InformativeInherited
Biological Process (BP)cellular aldehyde metabolic process0.0000000000000097770InformativeDirect
Biological Process (BP)response to oxidative stress0.0000000012640.000000002144InformativeDirect
Biological Process (BP)regulation of hormone levels0.000016270.00004384InformativeDirect
Biological Process (BP)protein transport0.000099730.0004808InformativeDirect
Biological Process (BP)secretion0.000012660.0001323InformativeDirect
Biological Process (BP)positive regulation of transport0.000040120.000806InformativeDirect
Biological Process (BP)monocarboxylic acid biosynthetic process0.000030480.00001126InformativeDirect
Biological Process (BP)organic hydroxy compound metabolic process0.0000000000044410.00000000002771InformativeDirect
Biological Process (BP)cellular response to oxygen-containing compound0.00021820.0005941InformativeDirect
Biological Process (BP)response to inorganic substance0.0097720.000184InformativeInherited
Biological Process (BP)negative regulation of cellular metabolic process0.0021880.1206InformativeInherited
Biological Process (BP)negative regulation of biosynthetic process0.000018610.02734InformativeInherited
Biological Process (BP)regulation of cell death0.000012730.001191InformativeInherited
Biological Process (BP)negative regulation of molecular function0.023050.01457InformativeInherited
Biological Process (BP)regulation of response to stress0.02280.009333InformativeInherited
Biological Process (BP)chemical homeostasis0.10960.04679InformativeInherited
Biological Process (BP)positive regulation of molecular function0.00011530.006377InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.0028180.002469InformativeInherited
Biological Process (BP)regulation of immune system process0.0026170.02873InformativeInherited
Biological Process (BP)mitochondrion organization0.0000076330.00001223Highly InformativeDirect
Biological Process (BP)cell-cell signaling0.0000006450.0005024Highly InformativeDirect
Biological Process (BP)regulation of transmembrane transporter activity0.00000000012250.00000000521Highly InformativeDirect
Biological Process (BP)protein repair00Highly InformativeDirect
Biological Process (BP)regulation of protein stability0.00000000039110.00000001226Highly InformativeDirect
Biological Process (BP)positive regulation of response to external stimulus0.00000024630.000009254Highly InformativeDirect
Biological Process (BP)carbohydrate homeostasis0.00000000018470.0000000286Highly InformativeDirect
Biological Process (BP)cellular response to reactive oxygen species0.000095020.000002019Highly InformativeDirect
Biological Process (BP)positive regulation of transmembrane transport0.000000000056620.0000000002549Highly InformativeDirect
Biological Process (BP)response to hydrogen peroxide0.0000001490.0000007821Highly InformativeDirect
Biological Process (BP)positive regulation of ion transport0.0000000019220.00000001505Highly InformativeDirect
Biological Process (BP)regulation of neuron apoptotic process0.000041290.00001619Highly InformativeDirect
Biological Process (BP)regulation of inflammatory response0.000016390.000006571Highly InformativeDirect
Biological Process (BP)regulation of binding0.00002510.00005954Highly InformativeDirect
Biological Process (BP)detoxification0.00000000012670.00000000001359Highly InformativeDirect
Biological Process (BP)regulation of reactive oxygen species metabolic process0.000000039480.0000000353Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.17860.1764Least InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)lyase activity0.00011250.000000008506Moderately InformativeDirect
Molecular Function (MF)metal ion binding0.19010.07876Moderately InformativeInherited
Molecular Function (MF)organic cyclic compound binding0.12190.8112Moderately InformativeInherited
Molecular Function (MF)heterocyclic compound binding0.09720.7859Moderately InformativeInherited
Molecular Function (MF)peptidase activity0.00000005720.0000005372InformativeDirect
Molecular Function (MF)carbon-oxygen lyase activity0.000000085460.0000000000006382InformativeDirect
Molecular Function (MF)RNA binding0.000032630.007166InformativeInherited
Molecular Function (MF)copper ion binding0.0000021360.000001829Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.01184 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.3522 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.9009 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.9972 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.9275 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.005007 Least Informative Inherited
Biological Process (BP) response to stimulus 0.6324 Least Informative Inherited
Biological Process (BP) carboxylic acid metabolic process 0.00003574 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.00005305 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.000009957 Moderately Informative Direct
Biological Process (BP) regulation of cellular metabolic process 0.912 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.6293 Moderately Informative Inherited
Biological Process (BP) cellular response to stimulus 0.06202 Moderately Informative Inherited
Biological Process (BP) negative regulation of biological process 0.5898 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.07077 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.4343 Moderately Informative Inherited
Biological Process (BP) macromolecule modification 0.03645 Moderately Informative Inherited
Biological Process (BP) response to chemical 0.008491 Moderately Informative Inherited
Biological Process (BP) response to stress 0.3423 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.1267 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.3007 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.5168 Moderately Informative Inherited
Biological Process (BP) cell communication 0.136 Moderately Informative Inherited
Biological Process (BP) transport 0.5944 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.03157 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.4422 Moderately Informative Inherited
Biological Process (BP) cellular protein metabolic process 0.1092 Moderately Informative Inherited
Biological Process (BP) single-organism localization 0.1443 Moderately Informative Inherited
Biological Process (BP) cellular aldehyde metabolic process 0 Informative Direct
Biological Process (BP) response to oxidative stress 0.000000002144 Informative Direct
Biological Process (BP) response to inorganic substance 0.000184 Informative Direct
Biological Process (BP) regulation of hormone levels 0.00004384 Informative Direct
Biological Process (BP) protein transport 0.0004808 Informative Direct
Biological Process (BP) secretion 0.0001323 Informative Direct
Biological Process (BP) positive regulation of transport 0.000806 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.00001126 Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0.00000000002771 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.0005941 Informative Direct
Biological Process (BP) negative regulation of cellular metabolic process 0.1206 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.02734 Informative Inherited
Biological Process (BP) regulation of cell death 0.001191 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.01457 Informative Inherited
Biological Process (BP) regulation of response to stress 0.009333 Informative Inherited
Biological Process (BP) chemical homeostasis 0.04679 Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.006377 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.002469 Informative Inherited
Biological Process (BP) regulation of immune system process 0.02873 Informative Inherited
Biological Process (BP) mitochondrion organization 0.00001223 Highly Informative Direct
Biological Process (BP) cell-cell signaling 0.0005024 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transporter activity 0.00000000521 Highly Informative Direct
Biological Process (BP) protein repair 0 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.00000001226 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0.000009254 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.0000000286 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 0.000002019 Highly Informative Direct
Biological Process (BP) positive regulation of transmembrane transport 0.0000000002549 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 0.0000007821 Highly Informative Direct
Biological Process (BP) positive regulation of ion transport 0.00000001505 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 0.00001619 Highly Informative Direct
Biological Process (BP) regulation of inflammatory response 0.000006571 Highly Informative Direct
Biological Process (BP) regulation of binding 0.00005954 Highly Informative Direct
Biological Process (BP) detoxification 0.00000000001359 Highly Informative Direct
Biological Process (BP) regulation of reactive oxygen species metabolic process 0.0000000353 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.1764 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) lyase activity 0.000000008506 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0.07876 Moderately Informative Inherited
Molecular Function (MF) organic cyclic compound binding 0.8112 Moderately Informative Inherited
Molecular Function (MF) heterocyclic compound binding 0.7859 Moderately Informative Inherited
Molecular Function (MF) peptidase activity 0.0000005372 Informative Direct
Molecular Function (MF) carbon-oxygen lyase activity 0.0000000000006382 Informative Direct
Molecular Function (MF) RNA binding 0.007166 Informative Inherited
Molecular Function (MF) copper ion binding 0.000001829 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Hydro-lyases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processStress response0InformativeDirect
Biological processFertilization0Highly InformativeDirect
Biological processInflammatory response0.00000000000002007Highly InformativeDirect
Biological processAutophagy0.0000000000000305Highly InformativeDirect
Cellular componentCytoplasm0.00007136Least InformativeDirect
Cellular componentMitochondrion0.000002096Moderately InformativeDirect
DiseaseTumor suppressor6.017e-16Moderately InformativeDirect
DomainTransit peptide0.0004548Moderately InformativeDirect
Molecular functionCopper0.0000000001877InformativeDirect
Post-translational modificationHydrolase0.00000000000007224Least InformativeDirect
Post-translational modificationLyase0.00000002486Moderately InformativeDirect
Post-translational modificationProtease0.00004623Moderately InformativeDirect
Post-translational modificationChaperone0.000000062InformativeDirect
Post-translational modificationAcetylation0.0001449Least InformativeDirect
Post-translational modificationIsopeptide bond0.00001308Moderately InformativeDirect
Post-translational modificationLipoprotein0.00003016Moderately InformativeDirect
Post-translational modificationUbl conjugation0.0001961Moderately InformativeDirect
Post-translational modificationZymogen0.0000002509InformativeDirect
Post-translational modificationOxidation0Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 35 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Class I glutamine amidotransferase-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]