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Ferredoxin reductase-like, C-terminal NADP-linked domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Ferredoxin reductase-like, C-terminal NADP-linked domain [ 52342]
Superfamily:   Ferredoxin reductase-like, C-terminal NADP-linked domain [ 52343] (5)
Families:   Reductases [ 52344] (4)
  Aromatic dioxygenase reductase-like [ 52359] (3)
  Dihydroorotate dehydrogenase B, PyrK subunit [ 52362]
  NADPH-cytochrome p450 reductase-like [ 52365] (3)
  Flavohemoglobin, C-terminal domain [ 52370]


Superfamily statistics
Genomes (2,831) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 20,550 124,278 57
Proteins 20,517 124,148 57


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0Moderately InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0.0000000000000101Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0.0000000000001728InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.1139InformativeInherited
Enzyme Commission (EC)With a heme protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Nitrate reductase (NADH)0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Sulfite reductase (NADPH)0Highly InformativeDirect
Enzyme Commission (EC)Nitric-oxide synthase0Highly InformativeDirect
Enzyme Commission (EC)Nitric oxide dioxygenase0.000000000001117Highly InformativeDirect
Enzyme Commission (EC)Nitrate reductase (NADPH)0.0000000006783Highly InformativeDirect
Enzyme Commission (EC)With a oxygen as acceptor0.000000004206Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)cardiovascular system disease0.007356Least InformativeInherited
Disease Ontology (DO)nervous system disease0.6885Least InformativeInherited
Disease Ontology (DO)artery disease0.006914Moderately InformativeInherited
Disease Ontology (DO)endocrine system disease0.01807Moderately InformativeInherited
Disease Ontology (DO)brain disease0.1503Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.2259Moderately InformativeInherited
Disease Ontology (DO)lower respiratory tract disease0.856Moderately InformativeInherited
Disease Ontology (DO)allergic rhinitis0.00002281InformativeDirect
Disease Ontology (DO)parasitic protozoa infectious disease0.00005773InformativeDirect
Disease Ontology (DO)migraine0.0001922InformativeDirect
Disease Ontology (DO)hypertension0.0006229InformativeDirect
Disease Ontology (DO)primary immunodeficiency disease0.06465InformativeInherited
Disease Ontology (DO)phagocyte bactericidal dysfunction0.0000004559Highly InformativeDirect
Disease Ontology (DO)hypothyroidism0.00003274Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.01363Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.01925Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.06748Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.2209Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.3367Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.422Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.4992Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.5297Least InformativeInherited
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.0008806Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.00175Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.002203Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.01748Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.02349Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.02581Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.05314Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.05636Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.09978Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.1234Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system physiology0.1425Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.1839Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.2278Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.2628Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.2842Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.2878Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.3448Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.3789Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.4685Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.4751Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.4862Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.7428Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal stomach morphology0.00005499InformativeDirect
Mammalian Phenotype (MP)abnormal kidney physiology0.0001307InformativeDirect
Mammalian Phenotype (MP)abnormal sensitivity to induced morbidity/mortality0.0002845InformativeDirect
Mammalian Phenotype (MP)abnormal amino acid level0.0005678InformativeDirect
Mammalian Phenotype (MP)impaired muscle contractility0.0006307InformativeDirect
Mammalian Phenotype (MP)abnormal lung morphology0.0007107InformativeDirect
Mammalian Phenotype (MP)abnormal bone ossification0.001258InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.001461InformativeInherited
Mammalian Phenotype (MP)abnormal renal tubule morphology0.003436InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.003654InformativeInherited
Mammalian Phenotype (MP)abnormal cholesterol level0.003989InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.005592InformativeInherited
Mammalian Phenotype (MP)abnormal renal corpuscle morphology0.00763InformativeInherited
Mammalian Phenotype (MP)abnormal response to injury0.01164InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.01652InformativeInherited
Mammalian Phenotype (MP)abnormal circulating lipid level0.02046InformativeInherited
Mammalian Phenotype (MP)abnormal cardiac muscle contractility0.02216InformativeInherited
Mammalian Phenotype (MP)abnormal circulating lipoprotein level0.02321InformativeInherited
Mammalian Phenotype (MP)abnormal smooth muscle morphology0.02592InformativeInherited
Mammalian Phenotype (MP)abnormal urine homeostasis0.03157InformativeInherited
Mammalian Phenotype (MP)abnormal CNS synaptic transmission0.03927InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.0403InformativeInherited
Mammalian Phenotype (MP)abnormal ion homeostasis0.04529InformativeInherited
Mammalian Phenotype (MP)abnormal phagocyte morphology0.06415InformativeInherited
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.07146InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary hormone level0.099InformativeInherited
Mammalian Phenotype (MP)abnormal heartbeat0.1016InformativeInherited
Mammalian Phenotype (MP)abnormal circulating enzyme level0.1069InformativeInherited
Mammalian Phenotype (MP)increased leukocyte cell number0.1234InformativeInherited
Mammalian Phenotype (MP)abnormal intestine physiology0.1683InformativeInherited
Mammalian Phenotype (MP)abnormal white adipose tissue morphology0.2134InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.2493InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.3495InformativeInherited
Mammalian Phenotype (MP)pyloric sphincter hypertrophy0.00000000184Highly InformativeDirect
Mammalian Phenotype (MP)glomerular capillary thrombosis0.000000009012Highly InformativeDirect
Mammalian Phenotype (MP)decreased urine sodium level0.00000001227Highly InformativeDirect
Mammalian Phenotype (MP)perivascular fibrosis0.00000007746Highly InformativeDirect
Mammalian Phenotype (MP)abnormal nitric oxide homeostasis0.0000001161Highly InformativeDirect
Mammalian Phenotype (MP)decreased systemic arterial blood pressure0.0000001356Highly InformativeDirect
Mammalian Phenotype (MP)increased blood osmolality0.0000002306Highly InformativeDirect
Mammalian Phenotype (MP)increased renal tubule apoptosis0.0000007317Highly InformativeDirect
Mammalian Phenotype (MP)renal tubular necrosis0.0000007317Highly InformativeDirect
Mammalian Phenotype (MP)increased prostaglandin level0.0000007317Highly InformativeDirect
Mammalian Phenotype (MP)liver vascular congestion0.000002682Highly InformativeDirect
Mammalian Phenotype (MP)polydipsia0.000005529Highly InformativeDirect
Mammalian Phenotype (MP)pulmonary vascular congestion0.000007513Highly InformativeDirect
Mammalian Phenotype (MP)decreased adiponectin level0.000009974Highly InformativeDirect
Mammalian Phenotype (MP)increased white adipose tissue amount0.00002259Highly InformativeDirect
Mammalian Phenotype (MP)thick ventricular wall0.00002594Highly InformativeDirect
Mammalian Phenotype (MP)hypertension0.00003593Highly InformativeDirect
Mammalian Phenotype (MP)abnormal blood-brain barrier function0.00003654Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating LDL cholesterol level0.00004054Highly InformativeDirect
Mammalian Phenotype (MP)cardiac interstitial fibrosis0.00004054Highly InformativeDirect
Mammalian Phenotype (MP)abnormal bone mineralization0.00005051Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating alkaline phosphatase level0.00005192Highly InformativeDirect
Mammalian Phenotype (MP)increased systemic arterial systolic blood pressure0.00005999Highly InformativeDirect
Mammalian Phenotype (MP)increased osteoclast cell number0.00006649Highly InformativeDirect
Mammalian Phenotype (MP)cardiac hypertrophy0.00008656Highly InformativeDirect
Mammalian Phenotype (MP)glomerulosclerosis0.00009729Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart ventricle pressure0.00009804Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating creatinine level0.0001344Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating pituitary hormone level0.0002492Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart left ventricle size0.0003908Highly InformativeDirect
Mammalian Phenotype (MP)abnormal blood flow velocity0.0004933Highly InformativeDirect
Mammalian Phenotype (MP)reduced long term potentiation0.0006115Highly InformativeDirect
Mammalian Phenotype (MP)decreased heart rate0.0006115Highly InformativeDirect
Mammalian Phenotype (MP)increased blood urea nitrogen level0.0008018Highly InformativeDirect
Mammalian Phenotype (MP)altered response to CNS ischemic injury0.001365Highly InformativeInherited
Mammalian Phenotype (MP)increased heart ventricle size0.111Highly InformativeInherited
Mammalian Phenotype (MP)decreased susceptibility to injury0.1162Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.001753Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.007348Least InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.0002329Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.1084Moderately InformativeInherited
Worm Phenotype (WP)pattern protein expression variant0.0002676InformativeDirect
Worm Phenotype (WP)endosome morphology variant0.0009494InformativeDirect
Worm Phenotype (WP)lysosome-related organelle morphology variant0.0005974Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0InformativeDirect
Enzyme Commission (EC)Catalysing the translocation of inorganic cations0InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0.0000000000005343InformativeDirect
Enzyme Commission (EC)Acting on other nitrogenous compounds as donors0.00003635InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor0Highly InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0Highly InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0Highly InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0.0002266Highly InformativeDirect
Enzyme Commission (EC)With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen0.6846Highly InformativeInherited
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen1Highly InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 39 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Ferredoxin reductase-like, C-terminal NADP-linked domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 39 hidden Markov models representing the Ferredoxin reductase-like, C-terminal NADP-linked domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]