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Class I aminoacyl-tRNA synthetases (RS), catalytic domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Adenine nucleotide alpha hydrolase-like [ 52373] (3)
Superfamily:   Nucleotidylyl transferase [ 52374] (5)
Family:   Class I aminoacyl-tRNA synthetases (RS), catalytic domain [ 52375] (12)


Family statistics
Genomes (3,260) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 36,686 262,938 45
Proteins 36,637 262,773 45


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun0Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Methionine--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Acid--ammonia (or amide) ligases (amide synthases)0Highly InformativeDirect
Enzyme Commission (EC)Valine--tRNA ligase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the musculature0.0001759Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.02771Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.04084Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.06638Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.3915Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.5006Least InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0.00006553Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cerebrum0.0002532Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skull size0.02745Moderately InformativeInherited
Phenotypic Abnormality (PA)Neurodevelopmental delay0.06565Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal homeostasis0.07328Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.6083Moderately InformativeInherited
Phenotypic Abnormality (PA)Acidosis0.000001485InformativeDirect
Phenotypic Abnormality (PA)Abnormal liver morphology0.07377InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral subcortex0.5936InformativeInherited
Phenotypic Abnormality (PA)Hepatic steatosis0.00006118Highly InformativeDirect
Phenotypic Abnormality (PA)Hypoplasia of the corpus callosum0.0003444Highly InformativeDirect
Phenotypic Abnormality (PA)Atrophy/Degeneration affecting the cerebrum0.0189Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.317Least InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0000004417Least InformativeDirect
Worm Phenotype (WP)cell development variant0.00006713Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.0013Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.011Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.04962Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.001112Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.00976Moderately InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.04821Moderately InformativeInherited
Worm Phenotype (WP)germ cell differentiation variant0.0726Moderately InformativeInherited
Worm Phenotype (WP)cell cycle variant0.1591Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.4473Moderately InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.9027Moderately InformativeInherited
Worm Phenotype (WP)germ cell development variant0.981Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant1Moderately InformativeInherited
Worm Phenotype (WP)avoids bacterial lawn0.00000004577InformativeDirect
Worm Phenotype (WP)transgene expression increased0.0000005808InformativeDirect
Worm Phenotype (WP)pachytene progression during oogenesis variant0.0002605InformativeDirect
Worm Phenotype (WP)hermaphrodite physiology variant0.001457InformativeInherited
Worm Phenotype (WP)germ cell physiology variant0.003275InformativeInherited
Worm Phenotype (WP)endocytic transport defect0.004503InformativeInherited
Worm Phenotype (WP)oocyte morphology variant0.006238InformativeInherited
Worm Phenotype (WP)chemical resistant0.03837InformativeInherited
Worm Phenotype (WP)cell differentiation variant0.0000000000001912Highly InformativeDirect
Worm Phenotype (WP)hypoxia response variant0.0000000000003299Highly InformativeDirect
Worm Phenotype (WP)pleiotropic defects severe early emb0.00000000394Highly InformativeDirect
Worm Phenotype (WP)oocyte number decreased0.0002547Highly InformativeDirect
Worm Phenotype (WP)paraquat response variant0.0004993Highly InformativeDirect
Worm Phenotype (WP)nuclear appearance variant0.07071Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0.9321Least InformativeInherited
Yeast Phenotype (YP)nutrient utilization0.0481Moderately InformativeInherited
Yeast Phenotype (YP)heat sensitivity0.0008536InformativeDirect
Yeast Phenotype (YP)respiratory metabolism0.005023InformativeInherited
Yeast Phenotype (YP)mitochondrial genome maintenance0.0003635Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)decreased cell size0.00004919Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)urogenital system0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)0 seed germination stage0.000037InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-oxygen bonds0InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1InformativeInherited
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compounds0Highly InformativeDirect
Enzyme Commission (EC)Acid--ammonia (or amine) ligases (amide synthases)0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 114 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Nucleotidylyl transferase domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]