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Adenine nucleotide alpha hydrolases-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Adenine nucleotide alpha hydrolase-like [ 52373] (3)
Superfamily:   Adenine nucleotide alpha hydrolases-like [ 52402] (6)
Families:   N-type ATP pyrophosphatases [ 52403] (8)
  PP-loop ATPase [ 82359] (2)
  PAPS reductase-like [ 52410] (2)
  ETFP subunits [ 52432] (2)
  Universal stress protein-like [ 52436] (7)
  ThiI-like [ 142093] (2)


Superfamily statistics
Genomes (3,265) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 57,962 427,258 38
Proteins 54,215 394,732 38


Functional annotation
General category Metabolism
Detailed category Nucleotide metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.0003274Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds0Moderately InformativeDirect
Enzyme Commission (EC)Other carbon--nitrogen ligases0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N0InformativeDirect
Enzyme Commission (EC)Sulfurtransferases0InformativeDirect
Enzyme Commission (EC)Sulfate adenylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)GMP synthase (glutamine-hydrolyzing)0Highly InformativeDirect
Enzyme Commission (EC)Acid--ammonia (or amide) ligases (amide synthases)0Highly InformativeDirect
Enzyme Commission (EC)tRNA(Ile)-lysidine synthetase0Highly InformativeDirect
Enzyme Commission (EC)tRNA sulfurtransferase0Highly InformativeDirect
Enzyme Commission (EC)With a disulfide as acceptor0Highly InformativeDirect
Enzyme Commission (EC)FAD synthetase0.0000002237Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the digestive system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.05326Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.2158Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.4248Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of acid-base homeostasis0.001827Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.2218Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.2252Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system0.2341Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.2916Moderately InformativeInherited
Phenotypic Abnormality (PA)Abdominal symptom0InformativeDirect
Phenotypic Abnormality (PA)Hepatic steatosis0.0001505InformativeDirect
Phenotypic Abnormality (PA)Aciduria0.0009897InformativeDirect
Phenotypic Abnormality (PA)Reduced consciousness/confusion0.003093InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cell physiology0.03472InformativeInherited
Phenotypic Abnormality (PA)Vomiting0.00001642Highly InformativeDirect
Phenotypic Abnormality (PA)Coma0.0001505Highly InformativeDirect
Phenotypic Abnormality (PA)Jaundice0.0008015Highly InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.7139Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis0.01216InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0InformativeDirect
Enzyme Commission (EC)Other carbon--nitrogen ligases0InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N-donor0.00000000009243InformativeDirect
Enzyme Commission (EC)Sulfate adenylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Sulfurtransferases0Highly InformativeDirect
Enzyme Commission (EC)Acid--ammonia (or amine) ligases (amide synthases)0.000000000000002957Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 32 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Adenine nucleotide alpha hydrolases-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 32 hidden Markov models representing the Adenine nucleotide alpha hydrolases-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]