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Tubulin nucleotide-binding domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Tubulin nucleotide-binding domain-like [ 52489]
Superfamily:   Tubulin nucleotide-binding domain-like [ 52490]
Families:   Tubulin, GTPase domain [ 52491] (3)


Superfamily statistics
Genomes (3,030) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 10,893 76,293 19
Proteins 10,801 76,009 19


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of mental health0.01653Moderately InformativeInherited
Disease Ontology (DO)schizophrenia0.0008681InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.00006295Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.1614Least InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0.0371Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebrum0.05354Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cortical gyration0.00002595Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of brainstem morphology0.000193Highly InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0000005423Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.0000007072Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0003973Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.0005056Least InformativeDirect
Worm Phenotype (WP)blast cell physiology variant0.001025Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.001029Least InformativeInherited
Worm Phenotype (WP)cell development variant0.006223Least InformativeInherited
Worm Phenotype (WP)protein protein interaction variant0.00000000007446Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.00000006423Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.00001197Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.0002637Moderately InformativeDirect
Worm Phenotype (WP)neuron development variant0.002203Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant0.01Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.02403Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.04101Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant0.09998Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.1117Moderately InformativeInherited
Worm Phenotype (WP)drug response variant0.1601Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.8423Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.9084Moderately InformativeInherited
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.00000004491InformativeDirect
Worm Phenotype (WP)nicotine response variant0.00000008555InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.000002459InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.00006336InformativeDirect
Worm Phenotype (WP)cytokinesis variant emb0.00008146InformativeDirect
Worm Phenotype (WP)male mating variant0.00009911InformativeDirect
Worm Phenotype (WP)pericellular component morphology variant0.0003368InformativeDirect
Worm Phenotype (WP)mitosis variant0.0003882InformativeDirect
Worm Phenotype (WP)avoids bacterial lawn0.0004263InformativeDirect
Worm Phenotype (WP)cell component localization variant0.003491InformativeInherited
Worm Phenotype (WP)somatic gonad development variant0.003839InformativeInherited
Worm Phenotype (WP)nuclear appearance variant0.01154InformativeInherited
Worm Phenotype (WP)neuron morphology variant0.01846InformativeInherited
Worm Phenotype (WP)epithelial system development variant0.04927InformativeInherited
Worm Phenotype (WP)RNA expression variant0.2712InformativeInherited
Worm Phenotype (WP)egg laying variant0.5199InformativeInherited
Worm Phenotype (WP)locomotion reduced0.6712InformativeInherited
Worm Phenotype (WP)nuclear appearance number defective early emb0.0000000002312Highly InformativeDirect
Worm Phenotype (WP)nucleus defective early emb0.0000000002312Highly InformativeDirect
Worm Phenotype (WP)pronucleus centrosomes defective early emb0.0000000002312Highly InformativeDirect
Worm Phenotype (WP)pronuclear morphology defective early emb0.0000000002312Highly InformativeDirect
Worm Phenotype (WP)pronuclear nuclear appearance defective early emb0.00000000028Highly InformativeDirect
Worm Phenotype (WP)nuclear morphology variation early emb0.0000000003534Highly InformativeDirect
Worm Phenotype (WP)touch resistant0.00000000146Highly InformativeDirect
Worm Phenotype (WP)distal tip cell migration variant0.000000002544Highly InformativeDirect
Worm Phenotype (WP)spindle position orientation defective early emb0.0000002464Highly InformativeDirect
Worm Phenotype (WP)RAB-11 recycling endosome localization variant0.0000005409Highly InformativeDirect
Worm Phenotype (WP)post hermaphrodite contact variant0.0000006067Highly InformativeDirect
Worm Phenotype (WP)dead eggs laid0.00001265Highly InformativeDirect
Worm Phenotype (WP)sluggish0.00001922Highly InformativeDirect
Worm Phenotype (WP)miRNA expression variant0.00002171Highly InformativeDirect
Worm Phenotype (WP)alae morphology variant0.0000407Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.00007488Highly InformativeDirect
Worm Phenotype (WP)male somatic gonad development variant0.0002366Highly InformativeDirect
Worm Phenotype (WP)gonad arm morphology variant0.0004041Highly InformativeDirect
Worm Phenotype (WP)nose touch variant0.0004173Highly InformativeDirect
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.002297Highly InformativeInherited
Worm Phenotype (WP)synapse morphology variant0.00491Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)fertile0.07203Moderately InformativeInherited
Fly Phenotype (FP)wild-type0.0002115InformativeDirect
Fly Phenotype (FP)cell cycle defective0.000267InformativeDirect
Fly Phenotype (FP)male fertile0.000004223Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)multi-tissue structure0.03936Least InformativeInherited
Fly Anatomy (FA)somatic cell0.952Least InformativeInherited
Fly Anatomy (FA)gonad0.003186Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.03549Moderately InformativeInherited
Fly Anatomy (FA)stem cell0.1809Moderately InformativeInherited
Fly Anatomy (FA)germline cell0.003575InformativeInherited
Fly Anatomy (FA)germline cyst0.006029InformativeInherited
Fly Anatomy (FA)male organism0.007678InformativeInherited
Fly Anatomy (FA)neuroblast0.03301InformativeInherited
Fly Anatomy (FA)spermatid0.00004537Highly InformativeDirect
Fly Anatomy (FA)type I neuroblast0.0001162Highly InformativeDirect
Fly Anatomy (FA)type II neuroblast0.0003479Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)sensory system0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.01477Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.07184Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.2095Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.2679Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.7782Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.00001098Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.004049Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.03671Moderately InformativeInherited
Xenopus ANatomical entity (XAN)epithelium0.000001159InformativeDirect
Xenopus ANatomical entity (XAN)dermal system0.0001532InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.001234InformativeInherited
Xenopus ANatomical entity (XAN)peripheral nervous system0.07827InformativeInherited
Xenopus ANatomical entity (XAN)anatomical space0.1048InformativeInherited
Xenopus ANatomical entity (XAN)endoderm0.1368InformativeInherited
Xenopus ANatomical entity (XAN)spinal cord0.1952InformativeInherited
Xenopus ANatomical entity (XAN)cell part0.000000000000004591Highly InformativeDirect
Xenopus ANatomical entity (XAN)epithelial cell0.00000000009773Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.000000002469Highly InformativeDirect
Xenopus ANatomical entity (XAN)vegetal hemisphere0.0001905Highly InformativeDirect
Xenopus ANatomical entity (XAN)gustatory system0.001319Highly InformativeInherited
Xenopus ANatomical entity (XAN)archenteron0.001642Highly InformativeInherited
Xenopus ANatomical entity (XAN)intersomitic region0.01104Highly InformativeInherited
Xenopus ANatomical entity (XAN)cranial nerve1Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.1936Least InformativeInherited
Plant ANatomical entity (PAN)portion of vascular tissue0.0006374InformativeDirect

Document: AP annotation of SCOP domains

InterPro annotation
Cross references IPR003008 SSF52490 Protein matches
Abstract

This domain is found in all tubulin chains, as well as the bacterial FtsZ family of proteins. These proteins are involved in polymer formation. Tubulin is the major component of microtubules, while FtsZ is the polymer-forming protein of bacterial cell division, it is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases, this entry is the GTPase domain. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in bacteria and archaea.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Tubulin nucleotide-binding domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 13 hidden Markov models representing the Tubulin nucleotide-binding domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]