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Tubulin nucleotide-binding domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Tubulin nucleotide-binding domain-like [ 52489]
Superfamily:   Tubulin nucleotide-binding domain-like [ 52490]
Families:   Tubulin, GTPase domain [ 52491] (3)


Superfamily statistics
Genomes (3,030) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 10,893 76,293 19
Proteins 10,801 76,009 19


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of mental health0.01653Moderately InformativeInherited
Disease Ontology (DO)schizophrenia0.0008681InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.0000589Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.1654Least InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0.03981Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of forebrain morphology0.06181Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of brainstem morphology0.00001081Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal cortical gyration0.00002925Highly InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0000006634Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.0000008514Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0001858Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.0003201Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.0008904Least InformativeDirect
Worm Phenotype (WP)cell development variant0.006088Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.0000165Moderately InformativeDirect
Worm Phenotype (WP)protein interaction variant0.00002785Moderately InformativeDirect
Worm Phenotype (WP)neuron development variant0.003833Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant0.01362Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.02302Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.04674Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.0769Moderately InformativeInherited
Worm Phenotype (WP)drug response variant0.08201Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.08251Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant0.1367Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.8294Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.9044Moderately InformativeInherited
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.00000001242InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.00000003618InformativeDirect
Worm Phenotype (WP)nicotine response variant0.000000104InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.000003112InformativeDirect
Worm Phenotype (WP)cytokinesis variant emb0.00008709InformativeDirect
Worm Phenotype (WP)male mating variant0.0001089InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.0001623InformativeDirect
Worm Phenotype (WP)pericellular component morphology variant0.000345InformativeDirect
Worm Phenotype (WP)male gonad development variant0.0003537InformativeDirect
Worm Phenotype (WP)avoids bacterial lawn0.0004853InformativeDirect
Worm Phenotype (WP)mitosis variant0.0006027InformativeDirect
Worm Phenotype (WP)cell component localization variant0.003445InformativeInherited
Worm Phenotype (WP)somatic gonad development variant0.003884InformativeInherited
Worm Phenotype (WP)neuron morphology variant0.004657InformativeInherited
Worm Phenotype (WP)epithelial system development variant0.04874InformativeInherited
Worm Phenotype (WP)RNA expression variant0.2578InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.5786InformativeInherited
Worm Phenotype (WP)egg laying variant0.6171InformativeInherited
Worm Phenotype (WP)locomotion reduced0.663InformativeInherited
Worm Phenotype (WP)pronucleus centrosomes defective early emb0.00000000001367Highly InformativeDirect
Worm Phenotype (WP)touch resistant0.000000001954Highly InformativeDirect
Worm Phenotype (WP)distal tip cell migration variant0.00000000269Highly InformativeDirect
Worm Phenotype (WP)RAB-11 recycling endosome localization variant0.0000006011Highly InformativeDirect
Worm Phenotype (WP)post hermaphrodite contact variant0.0000006443Highly InformativeDirect
Worm Phenotype (WP)mitotic spindle defective early emb0.0000008642Highly InformativeDirect
Worm Phenotype (WP)dead eggs laid0.00001418Highly InformativeDirect
Worm Phenotype (WP)sluggish0.00002089Highly InformativeDirect
Worm Phenotype (WP)miRNA expression variant0.0000251Highly InformativeDirect
Worm Phenotype (WP)alae morphology variant0.00004075Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.00008135Highly InformativeDirect
Worm Phenotype (WP)male somatic gonad development variant0.0002367Highly InformativeDirect
Worm Phenotype (WP)gonad arm morphology variant0.0004042Highly InformativeDirect
Worm Phenotype (WP)dye filling defect0.000812Highly InformativeDirect
Worm Phenotype (WP)synapse morphology variant0.006688Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)fertile0.07092Moderately InformativeInherited
Fly Phenotype (FP)wild-type0.0002104InformativeDirect
Fly Phenotype (FP)cell cycle defective0.0002723InformativeDirect
Fly Phenotype (FP)male fertile0.000004319Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)cell0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0.03451Least InformativeInherited
Fly Anatomy (FA)gonad0.002821Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.03199Moderately InformativeInherited
Fly Anatomy (FA)stem cell0.1804Moderately InformativeInherited
Fly Anatomy (FA)germline cell0.003592InformativeInherited
Fly Anatomy (FA)male-specific anatomical entity0.00705InformativeInherited
Fly Anatomy (FA)neuroblast0.03067InformativeInherited
Fly Anatomy (FA)fat body0.03848InformativeInherited
Fly Anatomy (FA)fat cell0.000006377Highly InformativeDirect
Fly Anatomy (FA)spermatid0.0000403Highly InformativeDirect
Fly Anatomy (FA)type I neuroblast0.0001141Highly InformativeDirect
Fly Anatomy (FA)type II neuroblast0.0003795Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)sensory system0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.0306Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.1348Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.2599Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.2753Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.7799Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.00004642Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.01048Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.04522Moderately InformativeInherited
Xenopus ANatomical entity (XAN)epithelium0.000001176InformativeDirect
Xenopus ANatomical entity (XAN)dermal system0.0001633InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.001213InformativeInherited
Xenopus ANatomical entity (XAN)peripheral nervous system0.07834InformativeInherited
Xenopus ANatomical entity (XAN)anatomical space0.1238InformativeInherited
Xenopus ANatomical entity (XAN)endoderm0.141InformativeInherited
Xenopus ANatomical entity (XAN)spinal cord0.1968InformativeInherited
Xenopus ANatomical entity (XAN)cell part0.00000000000001081Highly InformativeDirect
Xenopus ANatomical entity (XAN)epithelial cell0.0000000001045Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.000000002385Highly InformativeDirect
Xenopus ANatomical entity (XAN)vegetal hemisphere0.0001975Highly InformativeDirect
Xenopus ANatomical entity (XAN)gustatory system0.001214Highly InformativeInherited
Xenopus ANatomical entity (XAN)archenteron0.001738Highly InformativeInherited
Xenopus ANatomical entity (XAN)intersomitic region0.01107Highly InformativeInherited
Xenopus ANatomical entity (XAN)cranial nerve1Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.1936Least InformativeInherited
Plant ANatomical entity (PAN)portion of vascular tissue0.0006374InformativeDirect

Document: AP annotation of SCOP domains

InterPro annotation
Cross references IPR003008 SSF52490 Protein matches
Abstract

This domain is found in all tubulin chains, as well as the bacterial FtsZ family of proteins. These proteins are involved in polymer formation. Tubulin is the major component of microtubules, while FtsZ is the polymer-forming protein of bacterial cell division, it is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases, this entry is the GTPase domain. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in bacteria and archaea.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Tubulin nucleotide-binding domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 13 hidden Markov models representing the Tubulin nucleotide-binding domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]