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Tubulin nucleotide-binding domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Tubulin nucleotide-binding domain-like [ 52489]
Superfamily:   Tubulin nucleotide-binding domain-like [ 52490]
Families:   Tubulin, GTPase domain [ 52491] (3)


Superfamily statistics
Genomes (3,030) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 10,893 63,286 19
Proteins 10,801 63,039 19


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Cellular Component (CC)non-membrane-bounded organelle0.000000000000024970Least InformativeDirect
Cellular Component (CC)cytoskeleton00Moderately InformativeDirect
Cellular Component (CC)microtubule cytoskeleton00.000000000000005967InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0.00005609 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.02984 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) reproduction 0.00000000006724 Moderately Informative Direct
Biological Process (BP) cellular localization 0.0000004355 Moderately Informative Direct
Biological Process (BP) single-organism transport 0.8132 Moderately Informative Inherited
Biological Process (BP) tissue development 0.008382 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.009041 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.2751 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.06083 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.905 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.4346 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.5433 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.944 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.000000004357 Informative Direct
Biological Process (BP) microtubule-based process 0 Informative Direct
Biological Process (BP) post-embryonic development 0.000000000002211 Informative Direct
Biological Process (BP) cell cycle process 0 Informative Direct
Biological Process (BP) multicellular organism reproduction 0.0000000003184 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0006974 Informative Direct
Biological Process (BP) growth 0 Informative Direct
Biological Process (BP) cellular protein complex assembly 0.00000005009 Informative Direct
Biological Process (BP) single organism reproductive process 0.0000000001216 Informative Direct
Biological Process (BP) cell development 0.0000003209 Informative Direct
Biological Process (BP) organelle localization 0.0000000002018 Informative Direct
Biological Process (BP) reproductive system development 0.000000000004014 Informative Direct
Biological Process (BP) supramolecular fiber organization 0.0001783 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.4899 Informative Inherited
Biological Process (BP) organelle assembly 0.02919 Informative Inherited
Biological Process (BP) mitochondrion organization 0.02189 Informative Inherited
Biological Process (BP) intracellular transport 0.03114 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.2388 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.00004472 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.0000005871 Highly Informative Direct
Biological Process (BP) trichome differentiation 0 Highly Informative Direct
Biological Process (BP) cell growth 0 Highly Informative Direct
Biological Process (BP) seed development 0 Highly Informative Direct
Biological Process (BP) protein polymerization 0.000000000000007296 Highly Informative Direct
Biological Process (BP) establishment of organelle localization 0.000000008091 Highly Informative Direct
Biological Process (BP) developmental growth involved in morphogenesis 0 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0.1373 Highly Informative Inherited
Biological Process (BP) nuclear chromosome segregation 0.3007 Highly Informative Inherited
Biological Process (BP) meiotic cell cycle 0.1271 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0492 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.01638 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.002001 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.007733 Moderately Informative Inherited
Molecular Function (MF) purine nucleotide binding 0.0001053 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.00013 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.00002967 Informative Direct
Molecular Function (MF) purine nucleoside binding 0.000000001868 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0000000002175 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.04157 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.01875 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.002543 Moderately Informative Inherited
Cellular Component (CC) mitochondrial envelope 0.2225 Moderately Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.000000000000005967 Informative Direct
Cellular Component (CC) outer membrane 0.00003913 Informative Direct
Cellular Component (CC) supramolecular polymer 0 Informative Direct
Cellular Component (CC) plastid 0.01119 Informative Inherited
Cellular Component (CC) mitochondrial outer membrane 0.0001983 Highly Informative Direct
Cellular Component (CC) spindle 0.000000007743 Highly Informative Direct
Cellular Component (CC) cytoplasmic microtubule 0.000000000000008837 Highly Informative Direct
Cellular Component (CC) chloroplast stroma 0.00004532 Highly Informative Direct
Cellular Component (CC) microtubule organizing center 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0Moderately InformativeDirect
Biological processAntibiotic resistance0.0002855InformativeDirect
Biological processSeptation0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionGTP-binding0InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationNitration0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR003008 SSF52490 Protein matches
Abstract

This domain is found in all tubulin chains, as well as the bacterial FtsZ family of proteins. These proteins are involved in polymer formation. Tubulin is the major component of microtubules, while FtsZ is the polymer-forming protein of bacterial cell division, it is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases, this entry is the GTPase domain. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in bacteria and archaea.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Tubulin nucleotide-binding domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the Tubulin nucleotide-binding domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]