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Thiamin diphosphate-binding fold (THDP-binding) superfamily
SCOP classification
| Root: | SCOP hierarchy in SUPERFAMILY [ 0] (11) |
| Class: | Alpha and beta proteins (a/b) [ 51349] (141) |
| | Mainly parallel beta sheets (beta-alpha-beta units) |
| Fold: | Thiamin diphosphate-binding fold (THDP-binding) [ 52517] |
| | 3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465 |
| Superfamily: | Thiamin diphosphate-binding fold (THDP-binding) [ 52518] (8) |
| Families: | Pyruvate oxidase and decarboxylase Pyr module [ 88724] (8) |
| | the N-terminal, Pyr module is separated from the C-terminal, PP module by an alpha/beta domain of Rossmann-like topology |
| | TK-like Pyr module [ 88735] (2) |
| | different order of the modules, PP module is N-terminal, Pyr module is next to it followed by a Rossmann-like domain |
| | Branched-chain alpha-keto acid dehydrogenase Pyr module [ 88741] (4) |
| | parent family to TK and PFOR
heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module |
| | PFOR Pyr module [ 88746] |
| | domains VI, I and II are arranged in the same way as the TK PP, Pyr and C domains |
| | Pyruvate oxidase and decarboxylase PP module [ 88749] (8) |
| | the N-terminal, Pyr module is separated from the C-terminal, PP module by an alpa/beta domain of Rossmann-like topology |
| | TK-like PP module [ 88760] (2) |
| | different order of the modules, PP module is N-terminal, Pyr module is next to it followed by a Rossmann-like domain |
| | Branched-chain alpha-keto acid dehydrogenase PP module [ 88766] (4) |
| | parent family to TK and PFOR
heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module |
| | PFOR PP module [ 88771] |
| | domains VI, I and II are arranged in the same way as the TK PP, Pyr and C domains |
Superfamily statistics
Functional annotation
| General category | General |
| Detailed category | Small molecule binding |
Function annotation of SCOP domain superfamilies
Jump to [ Top of page · SCOP classification · Functional annotation ]
Internal database links
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Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry
out SCOP domain assignments to all genomes at the superfamily level.
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Alignments of sequences to 45 models
in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical
are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.
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Browse and view proteins in genomes which have
different domain combinations including a Thiamin diphosphate-binding fold (THDP-binding) domain.
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Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.
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Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.
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There are 45 hidden Markov models representing the Thiamin diphosphate-binding fold (THDP-binding) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.
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Jump to [ Top of page · SCOP classification · Functional annotation · Internal database links ]
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