SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


G proteins family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   P-loop containing nucleoside triphosphate hydrolases [ 52539]
Superfamily:   P-loop containing nucleoside triphosphate hydrolases [ 52540] (24)
Family:   G proteins [ 52592] (78)


Family statistics
Genomes (3,263) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 79,090 417,982 261
Proteins 77,987 410,704 260


Enzyme Commission (EC)

(
show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.0000000000002694Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Sulfate adenylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Acting on GTP; involved in cellular and subcellula0Highly InformativeDirect
Enzyme Commission (EC)Adenylyl-sulfate kinase0.0000000000155Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Somatic mutation0.1596Moderately InformativeInherited
Mode of Inheritance (MI)Somatic mosaicism0.000002714Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature0.001836Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.0207Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.03577Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.07044Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.09936Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.2056Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.3889Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.4861Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.8151Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebrum0.0005458Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal eye physiology0.007542Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal ocular adnexa morphology0.008934Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.04135Moderately InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.05012Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.1236Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal homeostasis0.1617Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.2826Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.3186Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.4907Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thorax0.5451Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the outer ear0.001556InformativeInherited
Phenotypic Abnormality (PA)Abnormal fundus morphology0.01522InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart valve physiology0.0281InformativeInherited
Phenotypic Abnormality (PA)Abnormal involuntary eye movements0.06183InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral subcortex0.09814InformativeInherited
Phenotypic Abnormality (PA)Abnormal conjugate eye movement0.1691InformativeInherited
Phenotypic Abnormality (PA)Edema0.2376InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the inner ear0.2736InformativeInherited
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.3455InformativeInherited
Phenotypic Abnormality (PA)Abnormality of calvarial morphology0.3751InformativeInherited
Phenotypic Abnormality (PA)Visual impairment0.6575InformativeInherited
Phenotypic Abnormality (PA)Nystagmus0.0001053Highly InformativeDirect
Phenotypic Abnormality (PA)Precocious puberty0.0001606Highly InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of the abdominal wall musculature0.0003149Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal platelet function0.000503Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the optic disc0.0006327Highly InformativeDirect
Phenotypic Abnormality (PA)Nevus0.008367Highly InformativeInherited
Phenotypic Abnormality (PA)Morphological abnormality of the inner ear0.01314Highly InformativeInherited
Phenotypic Abnormality (PA)Visual field defect0.01892Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the rib cage0.1163Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal location of ears0.1392Highly InformativeInherited
Phenotypic Abnormality (PA)Reduced visual acuity0.5125Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.3836Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.6882Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.7253Least InformativeInherited
Mammalian Phenotype (MP)abnormal synaptic transmission0.1638Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.3996Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.4122Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.04305InformativeInherited
Mammalian Phenotype (MP)abnormal neurotransmitter secretion0.0002598Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.000000001781Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.000005452Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.00006721Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.0002057Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0005053Least InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0000001233Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0.0000001353Moderately InformativeDirect
Worm Phenotype (WP)germ cell development variant0.0001268Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.0001661Moderately InformativeDirect
Worm Phenotype (WP)germ cell differentiation variant0.001336Moderately InformativeInherited
Worm Phenotype (WP)organ system development variant0.003088Moderately InformativeInherited
Worm Phenotype (WP)cell death variant0.006635Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.00977Moderately InformativeInherited
Worm Phenotype (WP)protein expression variant0.01289Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.0139Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.0261Moderately InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.04044Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.04063Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.6206Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant1Moderately InformativeInherited
Worm Phenotype (WP)tail bend angle variant0.000000000000357InformativeDirect
Worm Phenotype (WP)head movement variant0.000000000003766InformativeDirect
Worm Phenotype (WP)body posture variant0.000000001238InformativeDirect
Worm Phenotype (WP)foraging behavior variant0.000000004871InformativeDirect
Worm Phenotype (WP)nervous system physiology variant0.00000005076InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.0000005971InformativeDirect
Worm Phenotype (WP)forward locomotion variant0.0000007755InformativeDirect
Worm Phenotype (WP)fat content variant0.0000705InformativeDirect
Worm Phenotype (WP)cytokinesis variant emb0.0001013InformativeDirect
Worm Phenotype (WP)chemosensory response variant0.0001065InformativeDirect
Worm Phenotype (WP)hermaphrodite physiology variant0.0001212InformativeDirect
Worm Phenotype (WP)nuclear positioning variant0.0001828InformativeDirect
Worm Phenotype (WP)velocity of movement variant0.0004088InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.0004218InformativeDirect
Worm Phenotype (WP)vesicle organization variant0.0005666InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.0006917InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.1103InformativeInherited
Worm Phenotype (WP)pattern protein expression variant0.1355InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.1418InformativeInherited
Worm Phenotype (WP)oocyte morphology variant0.1565InformativeInherited
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.4585InformativeInherited
Worm Phenotype (WP)acetylcholinesterase inhibitor response variant0.4988InformativeInherited
Worm Phenotype (WP)cell stress response variant0.563InformativeInherited
Worm Phenotype (WP)cell number increased0.6314InformativeInherited
Worm Phenotype (WP)locomotion reduced0.9467InformativeInherited
Worm Phenotype (WP)carbon dioxide avoidance variant0.000000000000007815Highly InformativeDirect
Worm Phenotype (WP)dye filling defect0.00000000001207Highly InformativeDirect
Worm Phenotype (WP)male mating variant0.00000001613Highly InformativeDirect
Worm Phenotype (WP)multiple nuclei0.000001364Highly InformativeDirect
Worm Phenotype (WP)roaming variant0.00000169Highly InformativeDirect
Worm Phenotype (WP)fat0.000003488Highly InformativeDirect
Worm Phenotype (WP)foraging hyperactive0.000006343Highly InformativeDirect
Worm Phenotype (WP)actin organization biogenesis variant0.00002331Highly InformativeDirect
Worm Phenotype (WP)spindle position orientation defective early emb0.00002442Highly InformativeDirect
Worm Phenotype (WP)extra excretory cells0.00005122Highly InformativeDirect
Worm Phenotype (WP)synaptic transmission variant0.0001029Highly InformativeDirect
Worm Phenotype (WP)cell secretion variant0.0001486Highly InformativeDirect
Worm Phenotype (WP)endoplasmic reticulum morphology variant0.0001564Highly InformativeDirect
Worm Phenotype (WP)pausing variant0.0002258Highly InformativeDirect
Worm Phenotype (WP)drug induced gene expression variant0.0002692Highly InformativeDirect
Worm Phenotype (WP)protein phosphorylation variant0.00063Highly InformativeDirect
Worm Phenotype (WP)organism osmotic stress response variant0.01551Highly InformativeInherited
Worm Phenotype (WP)body region development variant0.01778Highly InformativeInherited
Worm Phenotype (WP)electrophysiology variant0.04997Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)intracellular transport0.06889InformativeInherited
Yeast Phenotype (YP)autophagy0.0007026Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)visible0.3302Moderately InformativeInherited
Fly Phenotype (FP)immune response defective0.0001114InformativeDirect
Fly Phenotype (FP)size defective0.04351InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0.1812Least InformativeInherited
Fly Anatomy (FA)somatic cell0.6582Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.9379Least InformativeInherited
Fly Anatomy (FA)tagma1Least InformativeInherited
Fly Anatomy (FA)segment1Least InformativeInherited
Fly Anatomy (FA)adult1Least InformativeInherited
Fly Anatomy (FA)circulatory system0.00087Moderately InformativeDirect
Fly Anatomy (FA)late embryo0.1331Moderately InformativeInherited
Fly Anatomy (FA)adult mesothoracic segment0.5468Moderately InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.6158Moderately InformativeInherited
Fly Anatomy (FA)adult external thorax0.8Moderately InformativeInherited
Fly Anatomy (FA)appendage0.8579Moderately InformativeInherited
Fly Anatomy (FA)anatomical space0.0008976InformativeDirect
Fly Anatomy (FA)fat body0.0114InformativeInherited
Fly Anatomy (FA)cuticular specialization0.203InformativeInherited
Fly Anatomy (FA)embryonic/larval fat body0.0001929Highly InformativeDirect
Fly Anatomy (FA)wing hair0.0007265Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.04779Least InformativeInherited
Xenopus ANatomical entity (XAN)urogenital system0.1491Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.2377Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk0.5288Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.5643Least InformativeInherited
Xenopus ANatomical entity (XAN)germ cell0.02484Moderately InformativeInherited
Xenopus ANatomical entity (XAN)testis0.1404Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.6161Moderately InformativeInherited
Xenopus ANatomical entity (XAN)epithelium0.8846InformativeInherited
Xenopus ANatomical entity (XAN)neuron0.6113Highly InformativeInherited
Xenopus ANatomical entity (XAN)olfactory system0.9602Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)sporangium0.00002091Least InformativeDirect
Plant ANatomical entity (PAN)gynoecium0.0008379Least InformativeDirect
Plant ANatomical entity (PAN)microgametophyte0.0155Least InformativeInherited
Plant ANatomical entity (PAN)megasporophyll0.3334Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.5373Least InformativeInherited
Plant ANatomical entity (PAN)pollen tube cell0.0000128InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferases1Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.000000000001547Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 512 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a P-loop containing nucleoside triphosphate hydrolases domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]