SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Arginase/deacetylase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Arginase/deacetylase [ 52767]
Superfamily:   Arginase/deacetylase [ 52768] (2)
Families:   Arginase-like amidino hydrolases [ 52769] (4)
  Histone deacetylase, HDAC [ 52773] (3)


Superfamily statistics
Genomes (2,302) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 10,963 67,757 30
Proteins 10,616 66,757 30


Functional annotation
General category Metabolism
Detailed category Amino acids metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)In linear amides0.8808Moderately InformativeInherited
Enzyme Commission (EC)In linear amidines0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.4675Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.4181Moderately InformativeInherited
Disease Ontology (DO)lymphoma0.002098InformativeInherited
Disease Ontology (DO)Hodgkin's lymphoma0.0001664Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0.1053Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.2525Least InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of higher mental function0Moderately InformativeDirect
Phenotypic Abnormality (PA)Neurodevelopmental abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the upper limb0.04175Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.04332Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.04577Moderately InformativeInherited
Phenotypic Abnormality (PA)Intellectual disability0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the palm0.0005405InformativeDirect
Phenotypic Abnormality (PA)Abnormal lower limb bone morphology0.003761InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia of the extremities0.003814InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.4905Least InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.2575Moderately InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.0845InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.00001384Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0007766Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.0009659Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.02745Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.1302Least InformativeInherited
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)metabolic pathway variant0.0000000001815Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.0000000008383Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.00000001346Moderately InformativeDirect
Worm Phenotype (WP)nervous system morphology variant0.0000005635Moderately InformativeDirect
Worm Phenotype (WP)reproductive system development variant0.1789Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.2239Moderately InformativeInherited
Worm Phenotype (WP)protein modification variant0InformativeDirect
Worm Phenotype (WP)male morphology variant0.000000009385InformativeDirect
Worm Phenotype (WP)sensillum morphology variant0.00000001822InformativeDirect
Worm Phenotype (WP)vulva development variant0.0002504InformativeDirect
Worm Phenotype (WP)spontaneous mutation rate increased0.00000002361Highly InformativeDirect
Worm Phenotype (WP)organism UV hypersensitive0.000001437Highly InformativeDirect
Worm Phenotype (WP)male ray morphology variant0.001058Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)cell0Least InformativeDirect
Fly Anatomy (FA)organism subdivision0Least InformativeDirect
Fly Anatomy (FA)adult tagma0Moderately InformativeDirect
Fly Anatomy (FA)neuron0Moderately InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)nervous system0.3164Least InformativeInherited
Zebrafish Anatomy (ZA)sensory system0.1032Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.2157Moderately InformativeInherited
Zebrafish Anatomy (ZA)post-vent region0InformativeDirect
Zebrafish Anatomy (ZA)surface structure0.0251InformativeInherited
Zebrafish Anatomy (ZA)lateral line system0.00006805Highly InformativeDirect
Zebrafish Anatomy (ZA)median fin0.0001196Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0Moderately InformativeDirect
Enzyme Commission (EC)In linear amides1InformativeInherited
Enzyme Commission (EC)In linear amidines0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAcetoin catabolism0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 21 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Arginase/deacetylase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 21 hidden Markov models representing the Arginase/deacetylase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]