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CoA-dependent acyltransferases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   CoA-dependent acyltransferases [ 52776]
Superfamily:   CoA-dependent acyltransferases [ 52777] (3)
Families:   CAT-like [ 52778] (3)
  Choline/Carnitine O-acyltransferase [ 82424] (3)
  NRPS condensation domain (amide synthase) [ 75229] (2)


Superfamily statistics
Genomes (2,812) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 46,979 330,841 39
Proteins 20,615 140,583 26


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds0.9887Moderately InformativeInherited
Enzyme Commission (EC)Racemases and epimerases0.001299Moderately InformativeInherited
Enzyme Commission (EC)Carboxy-lyases0.01725Moderately InformativeInherited
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.06325Moderately InformativeInherited
Enzyme Commission (EC)Acting on amino acids and derivatives0.00003344InformativeDirect
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0.08881InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.566InformativeInherited
Enzyme Commission (EC)Dihydrolipoyllysine-residue succinyltransferase0Highly InformativeDirect
Enzyme Commission (EC)N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valin0Highly InformativeDirect
Enzyme Commission (EC)Dihydrolipoyllysine-residue acetyltransferase0Highly InformativeDirect
Enzyme Commission (EC)L-aminoadipate-semialdehyde dehydrogenase0.00000000000001237Highly InformativeDirect
Enzyme Commission (EC)Phenylalanine racemase (ATP-hydrolyzing)0.000000000000279Highly InformativeDirect
Enzyme Commission (EC)Dihydrolipoyllysine-residue (2-methylpropanoyl)tra0.00000000546Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)gastrointestinal system disease0.02467Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.02589Moderately InformativeInherited
Disease Ontology (DO)liver disease0.002241InformativeInherited
Disease Ontology (DO)primary biliary cirrhosis0.00001062Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the musculature0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1378Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.3904Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal muscle tone0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of acid-base homeostasis0.001827Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.1608Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.2385Moderately InformativeInherited
Phenotypic Abnormality (PA)Reduced consciousness/confusion0.02199InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cell physiology0.03472InformativeInherited
Phenotypic Abnormality (PA)Abdominal symptom0.08066InformativeInherited
Phenotypic Abnormality (PA)Coma0.0003117Highly InformativeDirect
Phenotypic Abnormality (PA)Feeding difficulties in infancy0.0008839Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details) Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.006035Least InformativeInherited
Worm Phenotype (WP)lipid metabolism variant0.002311InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)somatic cell0.2241Least InformativeInherited
Fly Anatomy (FA)adult0.4226Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)adult thorax0.1483Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.1885Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.2186Moderately InformativeInherited
Fly Anatomy (FA)syncytium0.003069InformativeInherited
Fly Anatomy (FA)muscle system0.004635InformativeInherited
Fly Anatomy (FA)flight muscle0.00003842Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)cell0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus DEvelopment stage (XDE)post-embryonic stage0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-carbon lyases0.1606Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.0000007377InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0.002437InformativeInherited
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)0.07881InformativeInherited
Enzyme Commission (EC)Lovastatin nonaketide synthase0.000005912Highly InformativeDirect
Enzyme Commission (EC)Acting on amino acids and derivatives0.00003987Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Highly InformativeInherited
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a CoA-dependent acyltransferases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the CoA-dependent acyltransferases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]