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Phosphotyrosine protein phosphatases I superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Phosphotyrosine protein phosphatases I-like [ 52787] (2)
Superfamily:   Phosphotyrosine protein phosphatases I [ 52788]
Families:   Low-molecular-weight phosphotyrosine protein phosphatases [ 52789] (2)

Superfamily statistics
Genomes (2,513) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 5,020 32,257 14
Proteins 5,012 32,204 14

Functional annotation
General category Regulation
Detailed category Kinases/phosphatases

Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)macromolecule metabolic process0.0017440.02379Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process0.039540.04362Least InformativeInherited
Biological Process (BP)primary metabolic process0.047170.1415Least InformativeInherited
Biological Process (BP)cellular protein modification process0.000022580.0003473Moderately InformativeDirect
Biological Process (BP)protein dephosphorylation0.0000000000017960.000000000001311Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.000035080.00006955Least InformativeDirect
Molecular Function (MF)hydrolase activity, acting on ester bonds00Moderately InformativeDirect
Molecular Function (MF)oxidoreductase activity0.33370.2022Moderately InformativeInherited
Molecular Function (MF)phosphatase activity00InformativeDirect
Molecular Function (MF)phosphoprotein phosphatase activity0.0000018760.001732Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) macromolecule metabolic process 0.02379 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.04362 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.1415 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0.0003473 Moderately Informative Direct
Biological Process (BP) protein dephosphorylation 0.000000000001311 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.00006955 Least Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 0.2022 Moderately Informative Inherited
Molecular Function (MF) phosphatase activity 0 Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 0.001732 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Acid phosphatase0.000005636Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentCytoplasm0.000001379Least InformativeDirect
DomainRedox-active center0InformativeDirect
Post-translational modificationHydrolase0.0000000000005021Least InformativeDirect
Post-translational modificationOxidoreductase0.00000000000002875Moderately InformativeDirect
Post-translational modificationProtein phosphatase0InformativeDirect
Post-translational modificationDisulfide bond0.000000002388Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000106 SSF52788 Protein matches

This entry represents the low molecular weight (LMW) protein-tyrosine phosphatases (or acid phosphatase), which act on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates [PubMed1587862, PubMed1304913]. The structure of a LMW PTPase has been solved by X-ray crystallography [PubMed8052313] and is found to form a single structural domain. It belongs to the alpha/beta class, with 6 alpha-helices and 4 beta-strands forming a 3-layer alpha-beta-alpha sandwich architecture.

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Phosphotyrosine protein phosphatases I domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the Phosphotyrosine protein phosphatases I superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]