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(Phosphotyrosine protein) phosphatases II superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   (Phosphotyrosine protein) phosphatases II [ 52798]
Superfamily:   (Phosphotyrosine protein) phosphatases II [ 52799] (5)
Families:   Dual specificity phosphatase-like [ 52800] (8)
  Higher-molecular-weight phosphotyrosine protein phosphatases [ 52805] (6)
  Myotubularin-like phosphatases [ 102422]
  Myo-inositol hexaphosphate phosphohydrolase (phytase) PhyA [ 117583]
  Mycobacterial PtpB-like [ 142348]


Superfamily statistics
Genomes (1,854) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 28,852 81,483 63
Proteins 25,546 73,511 60


Functional annotation
General category Regulation
Detailed category Kinases/phosphatases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)macromolecule metabolic process0.000012910Least InformativeDirect
Biological Process (BP)multicellular organismal process0.072870Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process0.002170Least InformativeInherited
Biological Process (BP)biological regulation0.29930Least InformativeInherited
Biological Process (BP)primary metabolic process0.073270.00000000000003926Least InformativeInherited
Biological Process (BP)cellular protein modification process00Moderately InformativeDirect
Biological Process (BP)regulation of cell communication0.0000029060Moderately InformativeDirect
Biological Process (BP)regulation of signaling0.000002940Moderately InformativeDirect
Biological Process (BP)regulation of response to stimulus0.000037460Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process0.000070360Moderately InformativeDirect
Biological Process (BP)negative regulation of metabolic process0.10010.01149Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.24630.03109Moderately InformativeInherited
Biological Process (BP)tissue development0.66771Moderately InformativeInherited
Biological Process (BP)regulation of molecular function0.0068320.0000000004154Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.027780Moderately InformativeInherited
Biological Process (BP)negative regulation of cell communication0.00040140InformativeDirect
Biological Process (BP)negative regulation of signaling0.00015070InformativeDirect
Biological Process (BP)regulation of protein modification process0.00000002010.00000000000001422InformativeDirect
Biological Process (BP)regulation of phosphorylation0.000000006540.00000156InformativeDirect
Biological Process (BP)regulation of transferase activity0.00000044610InformativeDirect
Biological Process (BP)negative regulation of response to stimulus0.0026290InformativeInherited
Biological Process (BP)negative regulation of molecular function0.0059180InformativeInherited
Biological Process (BP)embryo development0.036210.8411InformativeInherited
Biological Process (BP)epithelium development0.11230.006011InformativeInherited
Biological Process (BP)regulation of intracellular signal transduction0.022970.04665InformativeInherited
Biological Process (BP)negative regulation of cellular protein metabolic process0.044360InformativeInherited
Biological Process (BP)protein dephosphorylation00Highly InformativeDirect
Biological Process (BP)negative regulation of transferase activity0.000096170Highly InformativeDirect
Biological Process (BP)negative regulation of intracellular signal transduction0.00062170.000000000000001925Highly InformativeDirect
Biological Process (BP)morphogenesis of an epithelium0.20991Highly InformativeInherited
Biological Process (BP)gastrulation0.0016330.000005267Highly InformativeInherited
Biological Process (BP)negative regulation of protein modification process0.0026120Highly InformativeInherited
Biological Process (BP)negative regulation of phosphate metabolic process0.028440Highly InformativeInherited
Biological Process (BP)regulation of MAP kinase activity0.088740.000002941Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)hydrolase activity, acting on ester bonds00Moderately InformativeDirect
Molecular Function (MF)phosphatase activity00InformativeDirect
Molecular Function (MF)phosphoprotein phosphatase activity00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) primary metabolic process 0.00000000000003926 Least Informative Direct
Biological Process (BP) response to stimulus 0.000004937 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000000000003998 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.08282 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) immune system process 0.0000003797 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0.000003213 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.000001451 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.000001881 Moderately Informative Direct
Biological Process (BP) single organism signaling 0.0007076 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.0000000004154 Moderately Informative Direct
Biological Process (BP) organophosphate biosynthetic process 0.00008412 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.0623 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.5331 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.03109 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.002042 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.4869 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.005715 Moderately Informative Inherited
Biological Process (BP) defense response 0.5938 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.08374 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.1633 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.772 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.3625 Moderately Informative Inherited
Biological Process (BP) cell communication 0.00927 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.8968 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.7656 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.4882 Moderately Informative Inherited
Biological Process (BP) reproduction 0.225 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.2099 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.7703 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.8492 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.01149 Moderately Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.0000007444 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.00000000000001079 Informative Direct
Biological Process (BP) regulation of catabolic process 0.0003691 Informative Direct
Biological Process (BP) negative regulation of cell communication 0 Informative Direct
Biological Process (BP) negative regulation of signaling 0 Informative Direct
Biological Process (BP) hemopoiesis 0.00001493 Informative Direct
Biological Process (BP) regulation of protein modification process 0.00000000000001422 Informative Direct
Biological Process (BP) negative regulation of cellular protein metabolic process 0 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.00000000001247 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of locomotion 0.000001051 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.000003943 Informative Direct
Biological Process (BP) regulation of phosphorylation 0.00000156 Informative Direct
Biological Process (BP) negative regulation of molecular function 0 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0 Informative Direct
Biological Process (BP) cell development 0.0000001402 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.0000000004564 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.000004172 Informative Direct
Biological Process (BP) regulation of transferase activity 0 Informative Direct
Biological Process (BP) localization of cell 0.000000001326 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.4216 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.001562 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.0203 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) single-organism membrane organization 1 Informative Inherited
Biological Process (BP) response to nitrogen compound 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.01846 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.01464 Informative Inherited
Biological Process (BP) metal ion transport 0.6522 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.9022 Informative Inherited
Biological Process (BP) cation homeostasis 0.8436 Informative Inherited
Biological Process (BP) inorganic ion homeostasis 0.7191 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) embryo development 0.8411 Informative Inherited
Biological Process (BP) protein oligomerization 0.1486 Informative Inherited
Biological Process (BP) transmembrane transport 0.8902 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.02376 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.1777 Informative Inherited
Biological Process (BP) circulatory system development 0.7831 Informative Inherited
Biological Process (BP) post-embryonic development 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) generation of neurons 0.01325 Informative Inherited
Biological Process (BP) mitochondrion organization 0.3462 Informative Inherited
Biological Process (BP) organelle localization 0.9634 Informative Inherited
Biological Process (BP) central nervous system development 0.398 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.01558 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.6234 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.1326 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.08456 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.1255 Informative Inherited
Biological Process (BP) supramolecular fiber organization 0.6875 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.04665 Informative Inherited
Biological Process (BP) behavior 0.07672 Informative Inherited
Biological Process (BP) response to temperature stimulus 0.8784 Informative Inherited
Biological Process (BP) regulation of growth 0.2303 Informative Inherited
Biological Process (BP) secretion by cell 0.2437 Informative Inherited
Biological Process (BP) protein transport 0.3037 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.4608 Informative Inherited
Biological Process (BP) cell death 0.8187 Informative Inherited
Biological Process (BP) immune effector process 0.007569 Informative Inherited
Biological Process (BP) pigment metabolic process 0.06476 Informative Inherited
Biological Process (BP) epithelium development 0.006011 Informative Inherited
Biological Process (BP) single organism reproductive process 0.5557 Informative Inherited
Biological Process (BP) cell activation 0.001409 Informative Inherited
Biological Process (BP) lipid localization 0.2166 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.008005 Informative Inherited
Biological Process (BP) intracellular transport 0.2209 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.08669 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.8803 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.8051 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.1089 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.4778 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.0013 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.7733 Informative Inherited
Biological Process (BP) secondary metabolic process 0.3911 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) regulation of system process 0.04328 Informative Inherited
Biological Process (BP) immune response 0.03702 Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.00000122 Highly Informative Direct
Biological Process (BP) myeloid cell activation involved in immune response 0.000001388 Highly Informative Direct
Biological Process (BP) immune response-activating signal transduction 0.0001745 Highly Informative Direct
Biological Process (BP) protein dephosphorylation 0 Highly Informative Direct
Biological Process (BP) gastrulation 0.000005267 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0.000000000607 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.000778 Highly Informative Direct
Biological Process (BP) protein secretion 0.0000389 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell migration 0.0000002413 Highly Informative Direct
Biological Process (BP) negative regulation of cell development 0.00006181 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.0002422 Highly Informative Direct
Biological Process (BP) biological adhesion 0.0000007597 Highly Informative Direct
Biological Process (BP) cell projection assembly 0.000000886 Highly Informative Direct
Biological Process (BP) lipid modification 0 Highly Informative Direct
Biological Process (BP) epithelial cell differentiation 0.0003431 Highly Informative Direct
Biological Process (BP) regeneration 0.0000111 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.0000000001106 Highly Informative Direct
Biological Process (BP) regulation of MAP kinase activity 0.000002941 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0.00002053 Highly Informative Direct
Biological Process (BP) negative regulation of phosphate metabolic process 0 Highly Informative Direct
Biological Process (BP) alcohol catabolic process 0.000006473 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0.000000000000003734 Highly Informative Direct
Biological Process (BP) neuron development 0.0000002093 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 0.00000002607 Highly Informative Direct
Biological Process (BP) leukocyte migration 0.00001436 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.000000009911 Highly Informative Direct
Biological Process (BP) negative regulation of transferase activity 0 Highly Informative Direct
Biological Process (BP) cell chemotaxis 0.000001707 Highly Informative Direct
Biological Process (BP) cellular response to organonitrogen compound 0.0002909 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.00001352 Highly Informative Direct
Biological Process (BP) sensory organ morphogenesis 0.00004032 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.000000000000001925 Highly Informative Direct
Biological Process (BP) regulation of response to wounding 0.000002975 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0.0004652 Highly Informative Direct
Biological Process (BP) regulation of mitotic nuclear division 0.05257 Highly Informative Inherited
Biological Process (BP) regulation of chromosome organization 0.7073 Highly Informative Inherited
Biological Process (BP) regulation of chromosome segregation 0.0721 Highly Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle phase transition 0.001486 Highly Informative Inherited
Biological Process (BP) inorganic cation transmembrane transport 0.05456 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.1194 Highly Informative Inherited
Biological Process (BP) divalent inorganic cation transport 0.05456 Highly Informative Inherited
Biological Process (BP) kidney development 0.005437 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle 0.375 Highly Informative Inherited
Biological Process (BP) extracellular matrix organization 0.1012 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 0.007829 Highly Informative Inherited
Biological Process (BP) response to peptide hormone 0.00213 Highly Informative Inherited
Biological Process (BP) response to carbohydrate 0.004256 Highly Informative Inherited
Biological Process (BP) response to growth factor 0.1206 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.02729 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.02193 Highly Informative Inherited
Biological Process (BP) myeloid cell differentiation 0.02615 Highly Informative Inherited
Biological Process (BP) camera-type eye development 0.8127 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 1 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 0.461 Highly Informative Inherited
Biological Process (BP) negative regulation of homeostatic process 0.05285 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.0537 Highly Informative Inherited
Biological Process (BP) embryonic organ development 1 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.258 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 0.1226 Highly Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.763 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.1492 Highly Informative Inherited
Biological Process (BP) regulation of cell size 0.004556 Highly Informative Inherited
Biological Process (BP) carbohydrate homeostasis 0.001104 Highly Informative Inherited
Biological Process (BP) single-organism behavior 0.202 Highly Informative Inherited
Biological Process (BP) programmed cell death involved in cell development 0.09003 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.0223 Highly Informative Inherited
Biological Process (BP) innate immune response 0.3283 Highly Informative Inherited
Biological Process (BP) germ cell development 0.1844 Highly Informative Inherited
Biological Process (BP) lymphocyte activation 0.926 Highly Informative Inherited
Biological Process (BP) leukocyte differentiation 0.1754 Highly Informative Inherited
Biological Process (BP) cell-cell signaling 1 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.05018 Highly Informative Inherited
Biological Process (BP) cell maturation 0.4807 Highly Informative Inherited
Biological Process (BP) anatomical structure maturation 0.0152 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.2994 Highly Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.001512 Highly Informative Inherited
Biological Process (BP) post-embryonic animal morphogenesis 0.1602 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0.3411 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.001938 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.01168 Highly Informative Inherited
Biological Process (BP) mRNA processing 0.7173 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte mediated immunity 0.002093 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell proliferation 0.01235 Highly Informative Inherited
Biological Process (BP) regulation of cell killing 0.003008 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.03548 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.6732 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 0.1693 Moderately Informative Inherited
Molecular Function (MF) signal transducer activity 0.0000007518 Informative Direct
Molecular Function (MF) phospholipid binding 0.00009551 Informative Direct
Molecular Function (MF) phosphatase activity 0 Informative Direct
Molecular Function (MF) enzyme binding 0.0000002255 Informative Direct
Molecular Function (MF) molecular transducer activity 0.000001684 Informative Direct
Molecular Function (MF) sulfur compound binding 0.1137 Informative Inherited
Molecular Function (MF) identical protein binding 0.1756 Informative Inherited
Molecular Function (MF) protein dimerization activity 0.3576 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) macromolecular complex binding 0.3734 Informative Inherited
Molecular Function (MF) nucleotidyltransferase activity 0.4377 Informative Inherited
Molecular Function (MF) phosphoprotein phosphatase activity 0 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 0.000000000003086 Highly Informative Direct
Molecular Function (MF) phosphatase regulator activity 0.000000004779 Highly Informative Direct
Molecular Function (MF) kinase binding 0.0000001062 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 0.0000194 Highly Informative Direct
Molecular Function (MF) cell adhesion molecule binding 0.000000007088 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.1512 Highly Informative Inherited
Cellular Component (CC) membrane 0.000007451 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.7009 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0.0000007779 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0005324 Moderately Informative Direct
Cellular Component (CC) cell projection 0.000000000000008837 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.02997 Moderately Informative Inherited
Cellular Component (CC) whole membrane 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.851 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.4308 Moderately Informative Inherited
Cellular Component (CC) endosome 0.0005813 Informative Direct
Cellular Component (CC) apical part of cell 0.000000000001654 Informative Direct
Cellular Component (CC) plasma membrane region 0.0000164 Informative Direct
Cellular Component (CC) side of membrane 0.01101 Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 1 Informative Inherited
Cellular Component (CC) neuron projection 0.4458 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 0.7747 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.1468 Informative Inherited
Cellular Component (CC) cilium 0.206 Informative Inherited
Cellular Component (CC) cytoplasmic vesicle part 0.2665 Informative Inherited
Cellular Component (CC) microtubule organizing center 0.0007412 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.000001895 Highly Informative Direct
Cellular Component (CC) lamellipodium 0.0003533 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.0000006215 Highly Informative Direct
Cellular Component (CC) exocytic vesicle 0.00003332 Highly Informative Direct
Cellular Component (CC) dendrite 0.04777 Highly Informative Inherited
Cellular Component (CC) cytoplasmic vesicle membrane 0.008819 Highly Informative Inherited
Cellular Component (CC) presynapse 0.3868 Highly Informative Inherited
Cellular Component (CC) cell-substrate adherens junction 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Phosphoprotein phosphatase0.00000002129InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0.000000001636Moderately InformativeDirect
Biological processCell cycle0.00004195Moderately InformativeDirect
Biological processHost-virus interaction0.01995Moderately InformativeInherited
Biological processCell adhesion0.0000000006961InformativeDirect
Biological processViral immunoevasion0.00002418InformativeDirect
Biological processMeiosis0.00008104InformativeDirect
Biological processAutophagy0.0001479InformativeDirect
Biological processStress response0.0009091InformativeDirect
Biological processCilium biogenesis/degradation0.00000007794Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentMembrane0.00000000186Least InformativeDirect
Cellular componentCytoplasm0.0001291Least InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoskeleton0.000000000000004523Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.00000007888Moderately InformativeDirect
Cellular componentHost cytoplasm0.00003516InformativeDirect
Coding sequence diversityAlternative splicing0.0001189Least InformativeDirect
Coding sequence diversityAlternative promoter usage0.0008053Moderately InformativeDirect
Developmental stageLate protein0.0000001477Least InformativeDirect
DomainSignal0.00000007485Least InformativeDirect
DomainRepeat0.000000166Least InformativeDirect
DomainTransmembrane0.00001178Least InformativeDirect
DomainCoiled coil0.00003784Moderately InformativeDirect
DomainImmunoglobulin domain0InformativeDirect
DomainSH2 domain0InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationReceptor0.00000000000009324Moderately InformativeDirect
Post-translational modificationProtein phosphatase0InformativeDirect
Post-translational modificationHeparin-binding0.0000000001059InformativeDirect
Post-translational modificationActin-binding0.0002647InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationMyristate0.0001834InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 27 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a (Phosphotyrosine protein) phosphatases II domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 27 hidden Markov models representing the (Phosphotyrosine protein) phosphatases II superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]