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(Phosphotyrosine protein) phosphatases II superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   (Phosphotyrosine protein) phosphatases II [ 52798]
Superfamily:   (Phosphotyrosine protein) phosphatases II [ 52799] (5)
Families:   Dual specificity phosphatase-like [ 52800] (8)
  Higher-molecular-weight phosphotyrosine protein phosphatases [ 52805] (6)
  Myotubularin-like phosphatases [ 102422]
  Myo-inositol hexaphosphate phosphohydrolase (phytase) PhyA [ 117583]
  Mycobacterial PtpB-like [ 142348]


Superfamily statistics
Genomes (1,854) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 28,852 101,343 63
Proteins 25,546 91,386 60


Functional annotation
General category Regulation
Detailed category Kinases/phosphatases

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Phosphoprotein phosphatase0.00000002129InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.7963Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.2483Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.5851Moderately InformativeInherited
Phenotypic Abnormality (PA)Hemangioma0.01275Highly InformativeInherited

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.7451Least InformativeInherited
Worm Phenotype (WP)cell physiology variant1Least InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.5368Moderately InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.0007598InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.05506InformativeInherited
Worm Phenotype (WP)cell component localization variant0.06477InformativeInherited
Worm Phenotype (WP)mitochondria alignment variant0.0007263Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)nervous system0.1056Least InformativeInherited
Fly Anatomy (FA)larva0.2592Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.3477Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.4682Least InformativeInherited
Fly Anatomy (FA)adult0.5888Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.00545Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.01506Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.01846Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system0.04925Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.06792Moderately InformativeInherited
Fly Anatomy (FA)head0.3065Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.4462Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.7614Moderately InformativeInherited
Fly Anatomy (FA)adult brain0.05203InformativeInherited
Fly Anatomy (FA)nerve0.07558InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.1094InformativeInherited
Fly Anatomy (FA)labral segment0.1238InformativeInherited
Fly Anatomy (FA)embryonic/larval peripheral nervous system0.1654InformativeInherited
Fly Anatomy (FA)supraesophageal ganglion0.1922InformativeInherited
Fly Anatomy (FA)neuromere0.2178InformativeInherited
Fly Anatomy (FA)synaptic neuropil domain0.4426InformativeInherited
Fly Anatomy (FA)intersegmental nerve0.000497Highly InformativeDirect
Fly Anatomy (FA)mushroom body medial lobe0.02446Highly InformativeInherited
Fly Anatomy (FA)adult mushroom body0.2107Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)sporangium0.0005902Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0.03255Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.1193Least InformativeInherited
Plant ANatomical entity (PAN)pollen0.0005422Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage0.001653Moderately InformativeInherited
Plant structure DEvelopment stage (PDE)L mature pollen stage0.0001031InformativeDirect
Plant structure DEvelopment stage (PDE)M germinated pollen stage0.0008222InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine phosphatase0.00000003493Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 77 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a (Phosphotyrosine protein) phosphatases II domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 77 hidden Markov models representing the (Phosphotyrosine protein) phosphatases II superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]