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Glutathione peroxidase-like family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Thioredoxin fold [ 52832] (2)
Superfamily:   Thioredoxin-like [ 52833] (23)
Family:   Glutathione peroxidase-like [ 52901] (28)


Family statistics
Genomes (2,998) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 10,418 62,969 65
Proteins 10,411 62,950 65


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Peroxidases0InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0.4604InformativeInherited
Enzyme Commission (EC)Protein-disulfide reductase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.006577Least InformativeInherited
Disease Ontology (DO)benign neoplasm0.00236Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.2411Moderately InformativeInherited
Disease Ontology (DO)cell type benign neoplasm0.001056InformativeInherited
Disease Ontology (DO)Parkinson's disease0.0001013Highly InformativeDirect
Disease Ontology (DO)adenoma0.0001742Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.006303Least InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.3392Moderately InformativeInherited
Mammalian Phenotype (MP)increased sensitivity to induced cell death0.0001791Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.6824Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.1303Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.1605Moderately InformativeInherited
Worm Phenotype (WP)chemical hypersensitive0.1472InformativeInherited
Worm Phenotype (WP)paraquat response variant0.000117Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0.8247Least InformativeInherited
Yeast Phenotype (YP)oxidative stress resistance0.0001384InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)stress response defective0.0001121Highly InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.0521Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.06033Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.1082Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster0.1875Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.2006Least InformativeInherited
Xenopus ANatomical entity (XAN)urogenital system0.2645Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk0.39Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.743Least InformativeInherited
Xenopus ANatomical entity (XAN)tail region0.0007994Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0.003543Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.05028Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.05943Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.07424Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.2483Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.2566Moderately InformativeInherited
Xenopus ANatomical entity (XAN)tail0.0003819InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.0006869InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.002734InformativeInherited
Xenopus ANatomical entity (XAN)skeletal system0.00287InformativeInherited
Xenopus ANatomical entity (XAN)solid compound organ0.01594InformativeInherited
Xenopus ANatomical entity (XAN)mesenchyme0.01763InformativeInherited
Xenopus ANatomical entity (XAN)neuroectoderm0.02241InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.02459InformativeInherited
Xenopus ANatomical entity (XAN)urinary system0.09533InformativeInherited
Xenopus ANatomical entity (XAN)pronephric tubule0.000001186Highly InformativeDirect
Xenopus ANatomical entity (XAN)splanchnocranium0.00001302Highly InformativeDirect
Xenopus ANatomical entity (XAN)presomitic mesoderm0.00003883Highly InformativeDirect
Xenopus ANatomical entity (XAN)foregut0.00006097Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region0.00007751Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranial neural crest0.0002623Highly InformativeDirect
Xenopus ANatomical entity (XAN)bone element0.0006291Highly InformativeDirect
Xenopus ANatomical entity (XAN)skeletal tissue0.0006833Highly InformativeDirect
Xenopus ANatomical entity (XAN)pronephric mesenchyme0.0006872Highly InformativeDirect
Xenopus ANatomical entity (XAN)primordium0.002058Highly InformativeInherited

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Moderately InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases0.04037InformativeInherited
Enzyme Commission (EC)Peroxidases0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.001148Highly InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 489 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Thioredoxin-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]