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Actin-like ATPase domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Ribonuclease H-like motif [ 53066] (7)
Superfamily:   Actin-like ATPase domain [ 53067] (14)
Families:   Actin/HSP70 [ 53068] (7)
  BadF/BadG/BcrA/BcrD-like [ 64089] (5)
  Acetokinase-like [ 53080] (3)
  ATPase domain of dehydratase reactivase alpha subunit [ 82440] (2)
  Hexokinase [ 53083] (3)
  Glycerol kinase [ 53089]
  Glucokinase [ 110627]
  Ppx/GppA phosphatase [ 110630]
  YeaZ-like [ 110633] (2)
  ROK [ 110636] (8)
  Cyto-EpsL domain [ 117644]
  Ta0583-like [ 142481]
  CoaX-like [ 142484]
  Fumble-like [ 159623] (3)


Superfamily statistics
Genomes (3,263) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 127,215 862,680 220
Proteins 73,626 521,206 111


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides1Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0.0000002262Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as accep0InformativeDirect
Enzyme Commission (EC)Glucokinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the digestive system0.001127Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.003976Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.02604Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.03341Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.05526Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.07863Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.1271Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.7279Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal muscle morphology0.007389Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skull morphology0.0821Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of forebrain morphology0.1301Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0.2005Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.2165Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.2496Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.5239Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.7952Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.8984Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the forehead0.04656InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral vasculature0.06513InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the calvaria0.128InformativeInherited
Phenotypic Abnormality (PA)Abnormal systemic arterial morphology0.1337InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature of the limbs0.3309InformativeInherited
Phenotypic Abnormality (PA)Functional abnormality of the gastrointestinal tract0.5953InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle size0.898InformativeInherited
Phenotypic Abnormality (PA)Abnormal gastrointestinal motility0.003872Highly InformativeInherited
Phenotypic Abnormality (PA)Cerebral ischemia0.004363Highly InformativeInherited
Phenotypic Abnormality (PA)Stroke0.006284Highly InformativeInherited
Phenotypic Abnormality (PA)Atrophy/Degeneration affecting the central nervous system0.07954Highly InformativeInherited
Phenotypic Abnormality (PA)Skeletal muscle atrophy0.1934Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.5572Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.2401Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.6713Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle fiber morphology0.05695Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.00002396Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.0000939Least InformativeDirect
Worm Phenotype (WP)blast cell physiology variant0.0001314Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.0001323Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.000208Least InformativeDirect
Worm Phenotype (WP)cell development variant0.0006025Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.001545Least InformativeInherited
Worm Phenotype (WP)protein protein interaction variant0.0000000327Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.0003867Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.000642Moderately InformativeDirect
Worm Phenotype (WP)cell division variant0.01759Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant0.06449Moderately InformativeInherited
Worm Phenotype (WP)protein expression variant0.2215Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.2275Moderately InformativeInherited
Worm Phenotype (WP)cytokinesis variant emb0.00000681InformativeDirect
Worm Phenotype (WP)avoids bacterial lawn0.000009307InformativeDirect
Worm Phenotype (WP)endocytic transport defect0.00004954InformativeDirect
Worm Phenotype (WP)brood size variant0.0001524InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.004606InformativeInherited
Worm Phenotype (WP)cell component localization variant0.008174InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.02381InformativeInherited
Worm Phenotype (WP)nuclear positioning variant0.02713InformativeInherited
Worm Phenotype (WP)level of protein expression variant0.06824InformativeInherited
Worm Phenotype (WP)mitochondria morphology variant0.1249InformativeInherited
Worm Phenotype (WP)egg laying variant0.6767InformativeInherited
Worm Phenotype (WP)dead eggs laid0.00001818Highly InformativeDirect
Worm Phenotype (WP)protein expression reduced0.0001471Highly InformativeDirect
Worm Phenotype (WP)muscle cell attachment variant0.000313Highly InformativeDirect
Worm Phenotype (WP)body wall muscle thick filament variant0.006774Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0.003782Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.1111Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.1238Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.7665Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.04538Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.1146Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.2914Moderately InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.003642InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.04158InformativeInherited
Xenopus ANatomical entity (XAN)pancreas0.0007949Highly InformativeDirect
Xenopus ANatomical entity (XAN)somite0.009071Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)fruit0.00001655InformativeDirect
Plant ANatomical entity (PAN)pollen tube cell0.00004227InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.0000006309InformativeDirect
Plant structure DEvelopment stage (PDE)seedling development stage0.00001084InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.6014Moderately InformativeInherited
Enzyme Commission (EC)Glycosylases1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)In phosphorus-containing anhydrides0.0008963InformativeDirect
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a carboxy group as acceptor0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Post-translational modificationHydrolase0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 190 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Actin-like ATPase domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 190 hidden Markov models representing the Actin-like ATPase domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]