SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Actin-like ATPase domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Ribonuclease H-like motif [ 53066] (7)
Superfamily:   Actin-like ATPase domain [ 53067] (14)
Families:   Actin/HSP70 [ 53068] (7)
  BadF/BadG/BcrA/BcrD-like [ 64089] (5)
  Acetokinase-like [ 53080] (3)
  ATPase domain of dehydratase reactivase alpha subunit [ 82440] (2)
  Hexokinase [ 53083] (3)
  Glycerol kinase [ 53089]
  Glucokinase [ 110627]
  Ppx/GppA phosphatase [ 110630]
  YeaZ-like [ 110633] (2)
  ROK [ 110636] (8)
  Cyto-EpsL domain [ 117644]
  Ta0583-like [ 142481]
  CoaX-like [ 142484]
  Fumble-like [ 159623] (3)


Superfamily statistics
Genomes (3,263) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 127,215 862,680 220
Proteins 73,626 521,206 111


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides1Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0.0000002262Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as accep0InformativeDirect
Enzyme Commission (EC)Glucokinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the digestive system0.001008Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.002893Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.01905Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.02873Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.07129Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.09428Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.1117Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.7156Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.02981Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skull morphology0.07081Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of forebrain morphology0.09237Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0.1504Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.1766Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.2084Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.5048Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.745Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.8743Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal systemic arterial morphology0.05532InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral vasculature0.102InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the calvaria0.1636InformativeInherited
Phenotypic Abnormality (PA)Functional abnormality of the gastrointestinal tract0.4783InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle size0.8026InformativeInherited
Phenotypic Abnormality (PA)Cerebral ischemia0.004881Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal gastrointestinal motility0.007057Highly InformativeInherited
Phenotypic Abnormality (PA)Stroke0.008445Highly InformativeInherited
Phenotypic Abnormality (PA)Atrophy/Degeneration affecting the central nervous system0.05355Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.5571Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.2397Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.6713Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle fiber morphology0.05696Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.00001397Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.0002571Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.000267Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.0004934Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.001618Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.002293Least InformativeInherited
Worm Phenotype (WP)larval development variant0.06959Least InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.00000005811Moderately InformativeDirect
Worm Phenotype (WP)endocytic transport variant0.00007867Moderately InformativeDirect
Worm Phenotype (WP)protein interaction variant0.000131Moderately InformativeDirect
Worm Phenotype (WP)cell division variant0.01694Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant0.07575Moderately InformativeInherited
Worm Phenotype (WP)protein expression variant0.1898Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.2453Moderately InformativeInherited
Worm Phenotype (WP)oocyte physiology variant0.000006004InformativeDirect
Worm Phenotype (WP)cytokinesis variant emb0.000007544InformativeDirect
Worm Phenotype (WP)avoids bacterial lawn0.00001324InformativeDirect
Worm Phenotype (WP)endocytic transport defect0.00006606InformativeDirect
Worm Phenotype (WP)brood size variant0.0002236InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.005124InformativeInherited
Worm Phenotype (WP)cell component localization variant0.0086InformativeInherited
Worm Phenotype (WP)nuclear positioning variant0.02155InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.02869InformativeInherited
Worm Phenotype (WP)level of protein expression variant0.06765InformativeInherited
Worm Phenotype (WP)mitochondria morphology variant0.1404InformativeInherited
Worm Phenotype (WP)egg laying variant0.7085InformativeInherited
Worm Phenotype (WP)dead eggs laid0.00002102Highly InformativeDirect
Worm Phenotype (WP)reduced brood size0.00007596Highly InformativeDirect
Worm Phenotype (WP)protein expression reduced0.0001688Highly InformativeDirect
Worm Phenotype (WP)muscle cell attachment variant0.0003395Highly InformativeDirect
Worm Phenotype (WP)L1 larval development variant0.0003469Highly InformativeDirect
Worm Phenotype (WP)body wall muscle thick filament variant0.006586Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0.003701Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.1187Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.1279Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.7683Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.03888Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.04917Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.1848Moderately InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.003544InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.05759InformativeInherited
Xenopus ANatomical entity (XAN)pancreas0.0007558Highly InformativeDirect
Xenopus ANatomical entity (XAN)somite0.01387Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)fruit0.00001655InformativeDirect
Plant ANatomical entity (PAN)pollen tube cell0.00004227InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.0000006309InformativeDirect
Plant structure DEvelopment stage (PDE)seedling development stage0.00001084InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.4656Moderately InformativeInherited
Enzyme Commission (EC)Glycosylases1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)In phosphorus-containing anhydrides0.0003134InformativeDirect
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a carboxy group as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Adenosinetriphosphatase0.0008781Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Post-translational modificationHydrolase0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 190 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Actin-like ATPase domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 190 hidden Markov models representing the Actin-like ATPase domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]