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Actin-like ATPase domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Ribonuclease H-like motif [ 53066] (7)
Superfamily:   Actin-like ATPase domain [ 53067] (14)
Families:   Actin/HSP70 [ 53068] (7)
  BadF/BadG/BcrA/BcrD-like [ 64089] (5)
  Acetokinase-like [ 53080] (3)
  ATPase domain of dehydratase reactivase alpha subunit [ 82440] (2)
  Hexokinase [ 53083] (3)
  Glycerol kinase [ 53089]
  Glucokinase [ 110627]
  Ppx/GppA phosphatase [ 110630]
  YeaZ-like [ 110633] (2)
  ROK [ 110636] (8)
  Cyto-EpsL domain [ 117644]
  Ta0583-like [ 142481]
  CoaX-like [ 142484]
  Fumble-like [ 159623] (3)


Superfamily statistics
Genomes (3,263) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 127,215 862,680 220
Proteins 73,626 521,206 111


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides1Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0.0000002262Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as accep0InformativeDirect
Enzyme Commission (EC)Glucokinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the digestive system0.001584Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.004616Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.02699Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.03477Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.06361Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.08763Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.1198Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.7257Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.03836Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skull morphology0.08932Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebrum0.1227Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0.1869Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.2103Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.2561Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.5009Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.7828Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.9061Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the forehead0.04223InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral vasculature0.06527InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the calvaria0.107InformativeInherited
Phenotypic Abnormality (PA)Abnormal systemic arterial morphology0.1276InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature of the limbs0.4633InformativeInherited
Phenotypic Abnormality (PA)Functional abnormality of the gastrointestinal tract0.5687InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle size0.736InformativeInherited
Phenotypic Abnormality (PA)Abnormal gastrointestinal motility0.002972Highly InformativeInherited
Phenotypic Abnormality (PA)Cerebral ischemia0.00394Highly InformativeInherited
Phenotypic Abnormality (PA)Stroke0.006875Highly InformativeInherited
Phenotypic Abnormality (PA)Atrophy/Degeneration affecting the central nervous system0.08838Highly InformativeInherited
Phenotypic Abnormality (PA)Skeletal muscle atrophy0.1841Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.557Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.2397Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.6713Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle fiber morphology0.05695Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.00000246Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.000122Least InformativeDirect
Worm Phenotype (WP)blast cell physiology variant0.0001746Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.0001756Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.0002068Least InformativeDirect
Worm Phenotype (WP)cell development variant0.0006533Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.001885Least InformativeInherited
Worm Phenotype (WP)protein protein interaction variant0.00000003183Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.0003505Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.0007573Moderately InformativeDirect
Worm Phenotype (WP)cell division variant0.01773Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant0.07533Moderately InformativeInherited
Worm Phenotype (WP)protein expression variant0.2255Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.2518Moderately InformativeInherited
Worm Phenotype (WP)cytokinesis variant emb0.000006722InformativeDirect
Worm Phenotype (WP)avoids bacterial lawn0.00001035InformativeDirect
Worm Phenotype (WP)endocytic transport defect0.00005323InformativeDirect
Worm Phenotype (WP)brood size variant0.0001834InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.004809InformativeInherited
Worm Phenotype (WP)cell component localization variant0.008689InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.02317InformativeInherited
Worm Phenotype (WP)nuclear positioning variant0.0263InformativeInherited
Worm Phenotype (WP)level of protein expression variant0.067InformativeInherited
Worm Phenotype (WP)mitochondria morphology variant0.1367InformativeInherited
Worm Phenotype (WP)egg laying variant0.6801InformativeInherited
Worm Phenotype (WP)dead eggs laid0.00001809Highly InformativeDirect
Worm Phenotype (WP)reduced brood size0.00006191Highly InformativeDirect
Worm Phenotype (WP)protein expression reduced0.0001595Highly InformativeDirect
Worm Phenotype (WP)muscle cell attachment variant0.0003249Highly InformativeDirect
Worm Phenotype (WP)body wall muscle thick filament variant0.006603Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0.00394Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.1201Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.1293Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.7686Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.04881Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.06512Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.1854Moderately InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.003691InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.05366InformativeInherited
Xenopus ANatomical entity (XAN)pancreas0.0007844Highly InformativeDirect
Xenopus ANatomical entity (XAN)somite0.01282Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)fruit0.00001655InformativeDirect
Plant ANatomical entity (PAN)pollen tube cell0.00004227InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.0000006309InformativeDirect
Plant structure DEvelopment stage (PDE)seedling development stage0.00001084InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.5981Moderately InformativeInherited
Enzyme Commission (EC)Glycosylases1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)In phosphorus-containing anhydrides0.0008816InformativeDirect
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a carboxy group as acceptor0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Post-translational modificationHydrolase0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 190 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Actin-like ATPase domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 190 hidden Markov models representing the Actin-like ATPase domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]