SUPERFAMILY 1.75 HMM library and genome assignments server

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Actin/HSP70 family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Ribonuclease H-like motif [ 53066] (7)
Superfamily:   Actin-like ATPase domain [ 53067] (14)
Family:   Actin/HSP70 [ 53068] (7)


Family statistics
Genomes (3,168) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 35,399 196,835 106
Proteins 19,445 110,209 53


Human Phenotype (HP)

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show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of limbs0.00249Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.01218Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.01305Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.02054Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.02385Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.02623Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.02999Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.1762Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.0001822Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the hand0.001548Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.04548Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal ocular adnexa morphology0.1419Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.1752Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal vascular morphology0.2208Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.2643Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0.2679Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.3538Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal systemic arterial morphology0.004764InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral vasculature0.0204InformativeInherited
Phenotypic Abnormality (PA)Functional abnormality of the gastrointestinal tract0.1289InformativeInherited
Phenotypic Abnormality (PA)Hydroureter0.00003239Highly InformativeDirect
Phenotypic Abnormality (PA)Cerebral ischemia0.0005144Highly InformativeDirect
Phenotypic Abnormality (PA)Stroke0.0008807Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal gastrointestinal motility0.001834Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cervical spine0.00808Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.4384Least InformativeInherited
Mammalian Phenotype (MP)abnormal response to injury0.03728InformativeInherited
Mammalian Phenotype (MP)altered response to CNS ischemic injury0.0006055Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.000000003194Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.000001319Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.000002135Least InformativeDirect
Worm Phenotype (WP)cell development variant0.0009519Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.001188Least InformativeInherited
Worm Phenotype (WP)protein protein interaction variant0.0000000005833Moderately InformativeDirect
Worm Phenotype (WP)germ cell development variant0.0006059Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.00148Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.007866Moderately InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.03364Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.05722Moderately InformativeInherited
Worm Phenotype (WP)protein expression variant0.097Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.2298Moderately InformativeInherited
Worm Phenotype (WP)hermaphrodite physiology variant0.0000002484InformativeDirect
Worm Phenotype (WP)cytokinesis variant emb0.000000762InformativeDirect
Worm Phenotype (WP)germ cell physiology variant0.000001436InformativeDirect
Worm Phenotype (WP)endocytic transport defect0.000002352InformativeDirect
Worm Phenotype (WP)brood size variant0.000004163InformativeDirect
Worm Phenotype (WP)avoids bacterial lawn0.00001151InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.0009634InformativeDirect
Worm Phenotype (WP)vulva morphology variant0.001801InformativeInherited
Worm Phenotype (WP)cell component localization variant0.003879InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.02525InformativeInherited
Worm Phenotype (WP)metal response variant0.03573InformativeInherited
Worm Phenotype (WP)nuclear positioning variant0.05375InformativeInherited
Worm Phenotype (WP)level of protein expression variant0.06638InformativeInherited
Worm Phenotype (WP)mitochondria morphology variant0.08371InformativeInherited
Worm Phenotype (WP)egg laying variant0.6387InformativeInherited
Worm Phenotype (WP)protein expression reduced0.00002964Highly InformativeDirect
Worm Phenotype (WP)muscle cell attachment variant0.0000923Highly InformativeDirect
Worm Phenotype (WP)cytoplasmic processing body variant0.0004342Highly InformativeDirect
Worm Phenotype (WP)germline nuclear positioning variant0.0004342Highly InformativeDirect
Worm Phenotype (WP)cleavage furrow defective early emb0.0007903Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)morphology0.05343Moderately InformativeInherited
Yeast Phenotype (YP)subcellular morphology0.6388InformativeInherited
Yeast Phenotype (YP)freeze-thaw resistance0.0009183Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0.003839Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.01593Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.02457Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.1045Least InformativeInherited
Xenopus ANatomical entity (XAN)tail region0.0004921Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0.003875Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.03457Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.08928Moderately InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.00007672InformativeDirect
Xenopus ANatomical entity (XAN)tail0.0006269InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.003011InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.005196InformativeInherited
Xenopus ANatomical entity (XAN)pancreas0.00009275Highly InformativeDirect
Xenopus ANatomical entity (XAN)head mesoderm0.0007881Highly InformativeDirect
Xenopus ANatomical entity (XAN)somite0.002278Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)pollen tube cell0.0001219InformativeDirect
Plant ANatomical entity (PAN)portion of ground tissue0.01783InformativeInherited
Plant ANatomical entity (PAN)trichome0.0002303Highly InformativeDirect
Plant structure DEvelopment stage (PDE)seedling development stage0.0000008126InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.000006498InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Acting on ATP; involved in cellular and subcellular movement0.00000002089InformativeDirect
Enzyme Commission (EC)In phosphorus-containing anhydrides1InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 190 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Actin-like ATPase domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]