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Molybdenum cofactor biosynthesis proteins superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Molybdenum cofactor biosynthesis proteins [ 53217]
Superfamily:   Molybdenum cofactor biosynthesis proteins [ 53218] (2)
Families:   MogA-like [ 53219] (5)
  MoeA central domain-like [ 64103] (2)


Superfamily statistics
Genomes (2,666) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 8,757 47,391 31
Proteins 8,319 46,232 31


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)primary metabolic process0.019540.03386Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.0015450.00000001568Least InformativeInherited
Biological Process (BP)macromolecule metabolic process0.0026260.0001978Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.0010280.000000002853Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process0.0059830.0005393Least InformativeInherited
Biological Process (BP)biosynthetic process0.0019930.0000005852Least InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.0000410.0000000002962Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process0.000018010Moderately InformativeDirect
Biological Process (BP)organophosphate biosynthetic process0.0000025830Moderately InformativeDirect
Biological Process (BP)organic cyclic compound biosynthetic process0.000062430.000000001694Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0.0000005852 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.0001978 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.000000002853 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.00000001568 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.0005393 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.02951 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.03386 Least Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.0000000002962 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.00000002679 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular localization 0.0000001933 Moderately Informative Direct
Biological Process (BP) organophosphate biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.000000001694 Moderately Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.000002 Informative Direct
Biological Process (BP) single-organism membrane organization 0.000000000000003734 Informative Direct
Biological Process (BP) protein localization to membrane 0 Highly Informative Direct
Biological Process (BP) Mo-molybdopterin cofactor metabolic process 0.128 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Molybdopterin adenylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Transferring molybdenum- or tungsten-containing gr0Highly InformativeDirect
Enzyme Commission (EC)FAD synthetase0.000000000004473Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processMolybdenum cofactor biosynthesis0Highly InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0.0001141Moderately InformativeDirect
Molecular functionMagnesium0.000000005362Least InformativeDirect
Molecular functionFlavoprotein0.0001005Moderately InformativeDirect
Molecular functionMolybdenum0InformativeDirect
Molecular functionFMN0.00000002225InformativeDirect
Molecular functionFAD0.000001268InformativeDirect
Post-translational modificationTransferase0.00000000000007113Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001453 SSF53218 Protein matches
Abstract Eukaryotic and prokaryotic molybdoenzymes require a molybdopterin cofactor (MoCF) for their activity. The biosynthesis of this cofactor involves a complex multistep enzymatic pathway. One of the eukaryotic proteins involved in this pathway is the Drosophila protein cinnamon [PubMed8088525] which is highly similar to gephyrin, a rat microtubule-associated protein which was thought to anchor the glycine receptor to subsynaptic microtubules.

Cinnamon and gephyrin are evolutionary related, in their N-terminal half, to the Escherichia coli MoCF biosynthesis proteins mog/chlG and moaB/chlA2 and, in their C-terminal half, to E. coli moeA/chlE.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 12 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Molybdenum cofactor biosynthesis proteins domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 12 hidden Markov models representing the Molybdenum cofactor biosynthesis proteins superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]