SUPERFAMILY 1.75 HMM library and genome assignments server

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vWA-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   vWA-like [ 53299]
Superfamily:   vWA-like [ 53300] (5)
Families:   Integrin A (or I) domain [ 53301] (10)
  Trunk domain of Sec23/24 [ 82458] (2)
  Ku70 subunit N-terminal domain [ 100959]
  Ku80 subunit N-terminal domain [ 100962]
  RoRNP C-terminal domain-like [ 142565]


Superfamily statistics
Genomes (2,591) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 35,043 178,602 53
Proteins 30,084 163,191 53


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0.000000001101Least InformativeDirect
Enzyme Commission (EC)Ligases0.04839Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.01625Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.0000000000001551Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)skin disease0.04544Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.2231Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.487Moderately InformativeInherited
Disease Ontology (DO)bullous pemphigoid0.0009174InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.01535InformativeInherited
Disease Ontology (DO)bullous skin disease0.01538InformativeInherited
Disease Ontology (DO)thrombocytopenia0.0003499Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of limbs0.1342Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.507Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.6808Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.698Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.8368Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.01576Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.01614Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle morphology0.2143Moderately InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0.3465Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.392Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.4844Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.5785Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.6782Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.8007Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.8485Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.9462Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of joint mobility0.1286InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb joint0.1825InformativeInherited
Phenotypic Abnormality (PA)Abnormality of eye movement0.2497InformativeInherited
Phenotypic Abnormality (PA)Abnormality of toe0.3374InformativeInherited
Phenotypic Abnormality (PA)Muscle weakness0.4384InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.4774InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.6816InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature of the neck0.002315Highly InformativeInherited
Phenotypic Abnormality (PA)Muscular dystrophy0.003304Highly InformativeInherited
Phenotypic Abnormality (PA)EMG abnormality0.02988Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle fibers0.03009Highly InformativeInherited
Phenotypic Abnormality (PA)Strabismus0.08366Highly InformativeInherited
Phenotypic Abnormality (PA)Weight loss0.1289Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature of the limbs0.1911Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of coordination0.2914Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.1562Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.4353Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.4483Least InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.3612Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.3909Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte migration0.0002833InformativeDirect
Mammalian Phenotype (MP)dermal-epidermal separation0.00001601Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cell adhesion0.0002995Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)muscle attachment variant0.00008774Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell shape defective0.0009327Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)embryo0Least InformativeDirect
Fly Anatomy (FA)larva0.1174Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.125Least InformativeInherited
Fly Anatomy (FA)integumentary system0.2988Least InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.07243Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.1335Moderately InformativeInherited
Fly Anatomy (FA)integumentary specialisation0.004902InformativeInherited
Fly Anatomy (FA)epithelial tube0.01411InformativeInherited
Fly Anatomy (FA)cuboidal/columnar epithelium0.01546InformativeInherited
Fly Anatomy (FA)muscle system0.01943InformativeInherited
Fly Anatomy (FA)embryonic/larval integumentary system0.0454InformativeInherited
Fly Anatomy (FA)endocuticle0.4363InformativeInherited
Fly Anatomy (FA)muscle attachment site0.00001533Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.0000000000001912Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.0000000004837Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases0.0004103Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0.01225Moderately InformativeInherited
Enzyme Commission (EC)Ligases0.09332Moderately InformativeInherited
Enzyme Commission (EC)DNA helicase0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.0000000000009039InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.000000000001652InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a vWA-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the vWA-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]