SUPERFAMILY 1.75 HMM library and genome assignments server

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vWA-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   vWA-like [ 53299]
Superfamily:   vWA-like [ 53300] (5)
Families:   Integrin A (or I) domain [ 53301] (10)
  Trunk domain of Sec23/24 [ 82458] (2)
  Ku70 subunit N-terminal domain [ 100959]
  Ku80 subunit N-terminal domain [ 100962]
  RoRNP C-terminal domain-like [ 142565]


Superfamily statistics
Genomes (2,591) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 35,043 178,602 53
Proteins 30,084 163,191 53


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0.000000001101Least InformativeDirect
Enzyme Commission (EC)Ligases0.04839Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.01625Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.0000000000001551Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)skin disease0.04563Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.2231Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.487Moderately InformativeInherited
Disease Ontology (DO)bullous pemphigoid0.0009256InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.01542InformativeInherited
Disease Ontology (DO)bullous skin disease0.01545InformativeInherited
Disease Ontology (DO)thrombocytopenia0.0003543Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of limbs0.1456Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.4885Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.7187Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.7232Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.8614Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.0186Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.06317Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal muscle morphology0.2207Moderately InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0.3412Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.4648Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.4683Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.5853Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.8103Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.8214Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.8474Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.947Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle fibers0.06153InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal muscles0.09352InformativeInherited
Phenotypic Abnormality (PA)Abnormality of joint mobility0.1166InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle size0.1654InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb joint0.2115InformativeInherited
Phenotypic Abnormality (PA)Abnormality of eye movement0.3037InformativeInherited
Phenotypic Abnormality (PA)Abnormality of toe0.3104InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hip bone0.4322InformativeInherited
Phenotypic Abnormality (PA)Muscle weakness0.4679InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.4928InformativeInherited
Phenotypic Abnormality (PA)Abnormality of finger0.684InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.7182InformativeInherited
Phenotypic Abnormality (PA)Muscular dystrophy0.003372Highly InformativeInherited
Phenotypic Abnormality (PA)Strabismus0.05608Highly InformativeInherited
Phenotypic Abnormality (PA)Weight loss0.1288Highly InformativeInherited
Phenotypic Abnormality (PA)Contractures of the joints of the lower limbs0.1341Highly InformativeInherited
Phenotypic Abnormality (PA)Skeletal muscle atrophy0.3383Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.156Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.4349Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.4479Least InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.361Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.3909Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte migration0.0002831InformativeDirect
Mammalian Phenotype (MP)dermal-epidermal separation0.00001602Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cell adhesion0.0002994Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)muscle attachment variant0.00008361Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0.1185Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.1498Least InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.071Moderately InformativeInherited
Fly Anatomy (FA)portion of tissue0.482Moderately InformativeInherited
Fly Anatomy (FA)integumentary specialisation0.004584InformativeInherited
Fly Anatomy (FA)tracheal system0.01157InformativeInherited
Fly Anatomy (FA)muscle system0.01951InformativeInherited
Fly Anatomy (FA)cuboidal/columnar epithelium0.02386InformativeInherited
Fly Anatomy (FA)epithelial tube0.02573InformativeInherited
Fly Anatomy (FA)embryonic/larval integumentary system0.04435InformativeInherited
Fly Anatomy (FA)endocuticle0.4372InformativeInherited
Fly Anatomy (FA)muscle attachment site0.00001474Highly InformativeDirect
Fly Anatomy (FA)primary trachea0.0005901Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage0.4989Moderately InformativeInherited
Xenopus DEvelopment stage (XDE)tailbud stage0.4174InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.0000000000002314Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.0000000003949Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases0.0004222Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0.0116Moderately InformativeInherited
Enzyme Commission (EC)Ligases0.09194Moderately InformativeInherited
Enzyme Commission (EC)DNA helicase0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.0000000000008822InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.000000000002009InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 22 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a vWA-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 22 hidden Markov models representing the vWA-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]