| Root: | SCOP hierarchy in SUPERFAMILY [ 0] (11) |
| Class: | Alpha and beta proteins (a/b) [ 51349] (141) |
| | Mainly parallel beta sheets (beta-alpha-beta units) |
| Fold: | S-adenosyl-L-methionine-dependent methyltransferases [ 53334] |
| | core: 3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest |
| Superfamily: | S-adenosyl-L-methionine-dependent methyltransferases [ 53335] (52) |
| Families: | COMT-like [ 53336] (3) |
| | Plant O-methyltransferase, C-terminal domain [ 64111] (5) |
| | RNA methyltransferase FtsJ [ 53339] |
| | Fibrillarin homologue [ 53342] |
| | rRNA methyltransferase RlmA [ 102557] |
| | rRNA methyltransferase AviRa [ 89738] |
| | rRNA adenine dimethylase-like [ 88784] (4) |
| | mRNA cap methylase [ 88785] (2) |
| | mRNA cap (Guanine N-7) methyltransferase [ 102560] |
| | mRNA capping enzyme |
| | Hypothetical protein MJ0882 [ 53345] |
| | Hypothetical protein HI0319 (YecO) [ 69544] |
| | Glycine N-methyltransferase [ 53348] |
| | Arylamine N-methyltransferase [ 69547] (2) |
| | Histamine methyltransferase [ 75261] |
| | Hypothetical Protein YjhP [ 82469] |
| | Salicylic acid carboxyl methyltransferase (SAMT) [ 102563] |
| | Thiopurine S-methyltransferase [ 102566] |
| | Leucine carboxy methyltransferase Ppm1 [ 102569] |
| | Precorrin-6Y methyltransferase (CbiT) [ 82472] |
| | MraW-like putative methyltransferases [ 82475] |
| | N5-glutamine methyltransferase, HemK [ 89743] |
| | Catalytic, N-terminal domain of histone methyltransferase Dot1l [ 89746] |
| | Guanidinoacetate methyltransferase [ 69550] |
| | Arginine methyltransferase [ 53351] (3) |
| | lacks the last two strands of the common fold replaced with a beta-sandwich oligomerisation subdomain |
| | Protein-L-isoaspartyl O-methyltransferase [ 53354] |
| | topological variant; strand order 3214567; strand 6 is antiparallel to the rest |
| | Glucose-inhibited division protein B (GidB) [ 75264] |
| | tRNA(1-methyladenosine) methyltransferase-like [ 64117] (4) |
| | contains additional N-terminal beta-sandwich domain |
| | NOL1/NOP2/sun [ 102575] (3) |
| | Pfam 01189; contains additional N-terminal 3-helical and ferredoxin-like domains |
| | Ribosomal protein L11 methyltransferase PrmA [ 102578] |
| | contains additional N-terminal ferredoxin-like domain |
| | (Uracil-5-)-methyltransferase [ 102581] |
| | Pfam 05958 |
| | Chemotaxis receptor methyltransferase CheR, C-terminal domain [ 53357] |
| | contains additional N-terminal all-alpha domain, res. 11-91 |
| | C5 cytosine-specific DNA methylase, DCM [ 88786] (3) |
| | DNA methylase TaqI, N-terminal domain [ 88787] |
| | N6 adenine-specific DNA methylase, DAM [ 88788] (2) |
| | Type II DNA methylase [ 53377] (3) |
| | circularly permuted version of the common fold |
| | Spermidine synthase [ 69557] (2) |
| | contains additional N-terminal tetramerisation all-beta domain, res. 1-71 |
| | Mycolic acid cyclopropane synthase [ 69560] (5) |
| | Ta1320-like [ 89751] (2) |
| | UbiE/COQ5-like [ 110671] (4) |
| | Pfam 01209 |
| | AD-003 protein-like [ 117685] (2) |
| | Pfam 05891; DUF858 |
| | CAC2371-like [ 117688] (3) |
| | similar overall fold to the Glycine N-methyltransferase (scop_fa 53348) and mRNA cap (Guanine N-7) methyltransferase (scop_fa 102560) families |
| | TehB-like [ 142603] |
| | Pfam 03848; overall structural similarity to Thiopurine S-methyltransferase (Pfam 05724) |
| | N-6 DNA Methylase-like [ 142606] (2) |
| | Pfam 02384; contains C-terminal extension to the canonical fold and extra N-terminal all-alpha domain similar to the insert domain of the DAM family (scop_fa 88788) |
| | YhhF-like [ 142611] (5) |
| | Pfam 03602 |
| | Met-10+ protein-like [ 142622] |
| | Pfam 02475; contains extra N-terminal alpha+beta domain: beta(2)-alpha-beta(2); mixed beta-sheet; order: 1234; cf scop_fold 102740 |
| | Nsp15 N-terminal domain-like [ 142625] |
| | rudiment methyltransferase fold that probably has lost the enzymatic activity; contains extra N-terminal alpha+beta subdomain |
| | BC2162-like [ 142629] |
| | contains extra helical regions inserted after strands 5 and 6 of the canonical fold |
| | CmcI-like [ 142632] |
| | Pfam 04989; may have evolved different enzymatic activity |
| | hypothetical RNA methyltransferase [ 142635] (4) |
| | C-terminal part of Pfam 03602; similar to (Uracil-5-)-methyltransferase (Pfam 05958) |
| | RPA4359-like [ 142644] |
| | Pfam 02636; DUF185 |
| | TrmB-like [ 142647] |
| | Pfam 02390 |
| | Methyltransferase 10 domain [ 142651] |
| | Pfam 05971; DUF890 |
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Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry
out SCOP domain assignments to all genomes at the superfamily level.
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Alignments of sequences to 118 models
in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical
are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.
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Browse and view proteins in genomes which have
different domain combinations including a S-adenosyl-L-methionine-dependent methyltransferases domain.
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Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.
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Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.
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There are 118 hidden Markov models representing the S-adenosyl-L-methionine-dependent methyltransferases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.
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