SUPERFAMILY 1.75 HMM library and genome assignments server

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Alkaline phosphatase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Alkaline phosphatase-like [ 53648]
Superfamily:   Alkaline phosphatase-like [ 53649] (5)
Families:   2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, catalytic domain [ 64162]
  Alkaline phosphatase [ 53650]
  Arylsulfatase [ 53653] (3)
  Phosphonoacetate hydrolase [ 102651]
  DeoB catalytic domain-like [ 142735]


Superfamily statistics
Genomes (3,036) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 24,514 195,350 33
Proteins 24,075 193,856 33


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.000000006922Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides1Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0.000001316Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0.3205Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.1016Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases (phosphomutases)0InformativeDirect
Enzyme Commission (EC)Nucleotide diphosphatase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoglycerate mutase0Highly InformativeDirect
Enzyme Commission (EC)Transferases for other substituted phosphate group0Highly InformativeDirect
Enzyme Commission (EC)Phosphodiesterase I4.713e-16Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of metabolism0.003165Moderately InformativeInherited
Disease Ontology (DO)lysosomal storage disease0.000001092InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.0007435Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.03769Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.1181Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.1347Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.2385Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.01911Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thorax0.02788Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system0.1003Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the spinal cord0.03756InformativeInherited
Phenotypic Abnormality (PA)Abnormal vertebral morphology0.04512InformativeInherited
Phenotypic Abnormality (PA)Abnormal facial shape0.08767InformativeInherited
Phenotypic Abnormality (PA)Urinary glycosaminoglycan excretion0.0000002852Highly InformativeDirect
Phenotypic Abnormality (PA)Dysostosis multiplex0.000001106Highly InformativeDirect
Phenotypic Abnormality (PA)Coarse facial features0.00001264Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal form of the vertebral bodies0.00009693Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the ribs0.0006649Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal enzyme/coenzyme activity0.01234Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.2076Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.3069Least InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype0.2855Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal fertility/fecundity0.1192InformativeInherited
Mammalian Phenotype (MP)abnormal lysosome physiology0.0000006091Highly InformativeDirect
Mammalian Phenotype (MP)abnormal glycosaminoglycan level0.0000006091Highly InformativeDirect
Mammalian Phenotype (MP)decreased litter size0.0005328Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0.2433Least InformativeInherited
Zebrafish Anatomy (ZA)organism subdivision0.3009Least InformativeInherited
Zebrafish Anatomy (ZA)compound organ0.3825Least InformativeInherited
Zebrafish Anatomy (ZA)head0.07624Moderately InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.2391Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.4037Moderately InformativeInherited
Zebrafish Anatomy (ZA)skeletal element0.00678InformativeInherited
Zebrafish Anatomy (ZA)pharyngeal arch0.01228InformativeInherited
Zebrafish Anatomy (ZA)skeletal system0.02336InformativeInherited
Zebrafish Anatomy (ZA)pharyngeal arch 2 skeleton0.001142Highly InformativeInherited
Zebrafish Anatomy (ZA)pharyngeal arch cartilage0.001808Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage0.6414Moderately InformativeInherited
Xenopus DEvelopment stage (XDE)gastrula stage0.1256Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.08457Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Intramolecular transferases0InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.00000000000002887InformativeDirect
Enzyme Commission (EC)In phosphorus-containing anhydrides0.00119InformativeInherited
Enzyme Commission (EC)Transferases for other substituted phosphate groups0Highly InformativeDirect
Enzyme Commission (EC)Phosphotransferases (phosphomutases)0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 12 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Alkaline phosphatase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 12 hidden Markov models representing the Alkaline phosphatase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]