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SIS domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   SIS domain [ 53696]
Superfamily:   SIS domain [ 53697] (3)
Families:   mono-SIS domain [ 69599] (5)
  double-SIS domain [ 53698] (4)
  Phosphoglucose isomerase, PGI [ 53701]


Superfamily statistics
Genomes (3,215) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 19,244 116,388 25
Proteins 19,132 116,122 25


Functional annotation
General category Metabolism
Detailed category Energy

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.16350.00000002224Least InformativeInherited
Biological Process (BP)single-organism cellular process0.39230.06567Least InformativeInherited
Biological Process (BP)biosynthetic process0.037630.00005156Least InformativeInherited
Biological Process (BP)macromolecule metabolic process0.053141Least InformativeInherited
Biological Process (BP)primary metabolic process0.47660.7065Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.000023570Moderately InformativeDirect
Biological Process (BP)cellular macromolecule biosynthetic process0.00023570.0002874Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process0.0000031140Moderately InformativeDirect
Biological Process (BP)lipid metabolic process0.0015360.0199Moderately InformativeInherited
Biological Process (BP)polysaccharide metabolic process0.0000065260.00000000003082InformativeDirect
Biological Process (BP)carbohydrate biosynthetic process0.000000036690InformativeDirect
Biological Process (BP)cellular carbohydrate metabolic process0.0000014630.000000001116InformativeDirect
Biological Process (BP)liposaccharide metabolic process0.000059880.00002154InformativeDirect
Biological Process (BP)lipopolysaccharide metabolic process0.00000015990.0000000008029Highly InformativeDirect
Biological Process (BP)cellular polysaccharide biosynthetic process0.000000012480.0000000000000376Highly InformativeDirect
Molecular Function (MF)isomerase activity0.000000000003820Moderately InformativeDirect
Molecular Function (MF)intramolecular oxidoreductase activity0.028220.0000000003559InformativeInherited
Molecular Function (MF)intramolecular oxidoreductase activity, interconverting aldoses and ketoses0.00000000000054430Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0.00005156 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.00000002224 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.3001 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.7065 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.0954 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.06567 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.02843 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.03265 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) generation of precursor metabolites and energy 0.000000000001216 Moderately Informative Direct
Biological Process (BP) nucleoside phosphate metabolic process 0.000005645 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0.0002874 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.0001347 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.0002215 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.00000002415 Moderately Informative Direct
Biological Process (BP) purine-containing compound metabolic process 0.0000000000004583 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.01677 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.00121 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.3031 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.3256 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.0199 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.0229 Moderately Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.00000000003082 Informative Direct
Biological Process (BP) monosaccharide metabolic process 0.0000000000007215 Informative Direct
Biological Process (BP) cellular aldehyde metabolic process 0.000004239 Informative Direct
Biological Process (BP) oxidoreduction coenzyme metabolic process 0 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0.000003935 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0.000000001116 Informative Direct
Biological Process (BP) ATP metabolic process 0 Informative Direct
Biological Process (BP) pyridine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) liposaccharide metabolic process 0.00002154 Informative Direct
Biological Process (BP) negative regulation of molecular function 0.005593 Informative Inherited
Biological Process (BP) phosphorylation 0.01671 Informative Inherited
Biological Process (BP) glucose metabolic process 0 Highly Informative Direct
Biological Process (BP) amino sugar metabolic process 0.0000001552 Highly Informative Direct
Biological Process (BP) glycolytic process 0 Highly Informative Direct
Biological Process (BP) lipopolysaccharide metabolic process 0.0000000008029 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.00004956 Highly Informative Direct
Biological Process (BP) cellular polysaccharide biosynthetic process 0.0000000000000376 Highly Informative Direct
Biological Process (BP) negative regulation of carbohydrate metabolic process 0.0000004048 Highly Informative Direct
Biological Process (BP) hexose biosynthetic process 0.017 Highly Informative Inherited
Molecular Function (MF) transferase activity 0.9608 Least Informative Inherited
Molecular Function (MF) isomerase activity 0 Moderately Informative Direct
Molecular Function (MF) intramolecular oxidoreductase activity 0.0000000003559 Informative Direct
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0.07201 Informative Inherited
Molecular Function (MF) transferase activity, transferring nitrogenous groups 0 Highly Informative Direct
Molecular Function (MF) intramolecular oxidoreductase activity, interconverting aldoses and ketoses 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.5544 Least Informative Inherited
Cellular Component (CC) protein-DNA complex 0.00003082 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Lyases0.000000002477Least InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Transferring nitrogenous groups0InformativeDirect
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related c0InformativeDirect
Enzyme Commission (EC)Glucokinase0.0000007307Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processGlycolysis0InformativeDirect
Biological processAngiogenesis0.0000207InformativeDirect
Biological processGluconeogenesis0Highly InformativeDirect
Biological processLipopolysaccharide biosynthesis0.0000000000001194Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCBS domain0Highly InformativeDirect
DomainGlutamine amidotransferase0Highly InformativeDirect
Molecular functionZinc0.0000000000008968Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationLyase0Moderately InformativeDirect
Post-translational modificationIsomerase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SIS domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the SIS domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]