SUPERFAMILY 1.75 HMM library and genome assignments server

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Ras-binding domain, RBD family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   beta-Grasp (ubiquitin-like) [ 54235] (14)
Superfamily:   Ubiquitin-like [ 54236] (8)
Family:   Ras-binding domain, RBD [ 54263] (13)


Family statistics
Genomes (114) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,145 3,111 26
Proteins 1,084 2,954 26


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0.000000000000001037Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.001842Moderately InformativeInherited
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.0004238InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4,5-bisphosphate 3-kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.6627Least InformativeInherited
Disease Ontology (DO)genetic disease0.09568Moderately InformativeInherited
Disease Ontology (DO)cell type cancer0.2432Moderately InformativeInherited
Disease Ontology (DO)head and neck carcinoma0.0003105InformativeDirect
Disease Ontology (DO)malignant glioma0.1077InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the immune system0.01467Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.04969Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.0783Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.2181Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.2248Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.3034Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.3207Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.001517Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thorax0.005994Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lymphatic system0.01183Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.03796Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.05953Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.0678Moderately InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.1258Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal homeostasis0.1916Moderately InformativeInherited
Phenotypic Abnormality (PA)Malignant neoplasm of the central nervous system0.00002733InformativeDirect
Phenotypic Abnormality (PA)Edema0.0006815InformativeDirect
Phenotypic Abnormality (PA)Neoplasm by histology0.002976InformativeInherited
Phenotypic Abnormality (PA)Epidermal thickening0.004406InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin pigmentation0.01707InformativeInherited
Phenotypic Abnormality (PA)Joint hypermobility0.0278InformativeInherited
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.03424InformativeInherited
Phenotypic Abnormality (PA)Neuroblastoma0.000003516Highly InformativeDirect
Phenotypic Abnormality (PA)Subcutaneous nodule0.00007004Highly InformativeDirect
Phenotypic Abnormality (PA)Cafe-au-lait spot0.0000737Highly InformativeDirect
Phenotypic Abnormality (PA)Nevus0.0001845Highly InformativeDirect
Phenotypic Abnormality (PA)Palmoplantar keratoderma0.0002633Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the sternum0.0003555Highly InformativeDirect
Phenotypic Abnormality (PA)Hyperpigmentation of the skin0.0009498Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the amniotic fluid0.002168Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.02111Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.02319Least InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.002887Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart ventricle wall thickness0.07128InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas physiology0.1534InformativeInherited
Mammalian Phenotype (MP)abnormal placenta morphology0.5459InformativeInherited
Mammalian Phenotype (MP)thick ventricular wall0.0003106Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)slow growth0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)larval arrest0Least InformativeDirect
Worm Phenotype (WP)progeny variant0Least InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)anatomical group0Least InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0.00000000002181Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.9195Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.0009164Moderately InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.05416Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases5.532e-16InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.00000001255Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 160 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Ubiquitin-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]