SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Ras-binding domain, RBD family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   beta-Grasp (ubiquitin-like) [ 54235] (14)
Superfamily:   Ubiquitin-like [ 54236] (8)
Family:   Ras-binding domain, RBD [ 54263] (13)


Family statistics
Genomes (114) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,145 3,111 26
Proteins 1,084 2,954 26


Enzyme Commission (EC)

(
show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0.000000000000001037Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.001842Moderately InformativeInherited
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.0004238InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4,5-bisphosphate 3-kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.6627Least InformativeInherited
Disease Ontology (DO)genetic disease0.09568Moderately InformativeInherited
Disease Ontology (DO)cell type cancer0.2432Moderately InformativeInherited
Disease Ontology (DO)head and neck carcinoma0.0003105InformativeDirect
Disease Ontology (DO)malignant glioma0.1077InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the immune system0.01472Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.0498Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.07845Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.2184Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.225Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.3038Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.321Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.001527Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thorax0.005989Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lymphatic system0.01193Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.03809Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.05974Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.06799Moderately InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.1255Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal homeostasis0.1918Moderately InformativeInherited
Phenotypic Abnormality (PA)Malignant neoplasm of the central nervous system0.00002731InformativeDirect
Phenotypic Abnormality (PA)Edema0.000689InformativeDirect
Phenotypic Abnormality (PA)Neoplasm by histology0.002975InformativeInherited
Phenotypic Abnormality (PA)Epidermal thickening0.004464InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin pigmentation0.01703InformativeInherited
Phenotypic Abnormality (PA)Joint hypermobility0.02769InformativeInherited
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.03424InformativeInherited
Phenotypic Abnormality (PA)Neuroblastoma0.000003514Highly InformativeDirect
Phenotypic Abnormality (PA)Subcutaneous nodule0.00006996Highly InformativeDirect
Phenotypic Abnormality (PA)Cafe-au-lait spot0.00007364Highly InformativeDirect
Phenotypic Abnormality (PA)Nevus0.0001843Highly InformativeDirect
Phenotypic Abnormality (PA)Palmoplantar keratoderma0.0002722Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the sternum0.0003553Highly InformativeDirect
Phenotypic Abnormality (PA)Hyperpigmentation of the skin0.0009491Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the amniotic fluid0.002169Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.02119Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.02317Least InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.002907Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart ventricle wall thickness0.07132InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas physiology0.1535InformativeInherited
Mammalian Phenotype (MP)abnormal placenta morphology0.5459InformativeInherited
Mammalian Phenotype (MP)thick ventricular wall0.0003107Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)slow growth0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)larval arrest0Least InformativeDirect
Worm Phenotype (WP)progeny variant0Least InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)anatomical group0Least InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0.00000000002181Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.9195Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.0009164Moderately InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.05416Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases5.532e-16InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.00000001255Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 160 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Ubiquitin-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]