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FAD-linked reductases, C-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   FAD-linked reductases, C-terminal domain [ 54372]
Superfamily:   FAD-linked reductases, C-terminal domain [ 54373] (7)
Families:   GMC oxidoreductases [ 54374] (5)
  PHBH-like [ 54378] (4)
  D-aminoacid oxidase-like [ 54384] (3)
  UDP-galactopyranose mutase [ 69670]
  L-aminoacid/polyamine oxidase [ 54394] (6)
  GDI-like [ 54399] (2)
  Electron transfer flavoprotein-ubiquinone oxidoreductase-like [ 142988]


Superfamily statistics
Genomes (2,803) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 27,554 181,448 74
Proteins 27,457 180,996 74


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.01911Least InformativeInherited
Enzyme Commission (EC)Acting on the CH-NH group of donors0.000005291Moderately InformativeDirect
Enzyme Commission (EC)Methyltransferases0.00001959Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-CH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red1Moderately InformativeInherited
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.0000000007149InformativeDirect
Enzyme Commission (EC)Aldehyde-lyases0.005472InformativeInherited
Enzyme Commission (EC)With oxygen as acceptor0.2536InformativeInherited
Enzyme Commission (EC)Acting on single donors with incorporation of mole0.9537InformativeInherited
Enzyme Commission (EC)tRNA (5-methylaminomethyl-2-thiouridylate)-methylt0Highly InformativeDirect
Enzyme Commission (EC)With other acceptors0Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With a quinone or similar compound as acceptor0.000000000000002558Highly InformativeDirect
Enzyme Commission (EC)With incorporation of one atom of oxygen0.0000000000001719Highly InformativeDirect
Enzyme Commission (EC)With a quinone or similar compound as acceptor0.000000009264Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)developmental timing variant0.5422Least InformativeInherited
Worm Phenotype (WP)life span variant0.0000004769InformativeDirect
Worm Phenotype (WP)hatching variant0.000001022Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus DEvelopment stage (XDE)post-embryonic stage0.1825Least InformativeInherited
Xenopus DEvelopment stage (XDE)climax stage0.06906Moderately InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage 620.0001313Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors0.0000000000001873Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups0.001304Moderately InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors0InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0.00000000005454InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.0000000001032InformativeDirect
Enzyme Commission (EC)Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated0.7837InformativeInherited
Enzyme Commission (EC)Intramolecular transferases0.8334InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate1InformativeInherited
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidase0.00000000000001286Highly InformativeDirect
Enzyme Commission (EC)With a quinone or similar compound as acceptor0.00000000005598Highly InformativeDirect
Enzyme Commission (EC)With a quinone or similar compound as acceptor0.000000002248Highly InformativeDirect
Enzyme Commission (EC)Aldehyde-lyases0.0004471Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 30 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FAD-linked reductases, C-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 30 hidden Markov models representing the FAD-linked reductases, C-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]