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NTF2-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Cystatin-like [ 54402] (7)
Superfamily:   NTF2-like [ 54427] (30)
Families:   Scytalone dehydratase [ 54428]
  NTF2-like [ 54431] (6)
  Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A [ 89851]
  Limonene-1,2-epoxide hydrolase-like [ 89854] (2)
  SnoaL-like polyketide cyclase [ 102810] (5)
  PhzA/PhzB-like [ 102813] (4)
  Ketosteroid isomerase-like [ 54434] (2)
  Ring hydroxylating beta subunit [ 54438] (6)
  Penicillin binding protein 2a (PBP2A), N-terminal domain [ 82595]
  Orange carotenoid protein, C-terminal domain [ 82598]
  Hypothetical protein egc068 from a soil-derived mobile gene cassette [ 110826]
  PA1314-like [ 110829]
  TIM44-like [ 143001]
  Sbal0622-like [ 159985]
  CHU142-like [ 159988]
  SO0125-like [ 159991] (2)
  SAV4671-like [ 159996]
  BxeB1374-like [ 159999] (2)
  Atu0744-like [ 160004]
  Rpa4348-like [ 160007] (2)
  Ava4193-like [ 160012]
  YybH-like [ 160015]
  PFL3262-like [ 160018]
  Exig0174-like [ 160021]
  Rv3472-like [ 160024] (2)
  VirB8-like [ 160029]
  ECA1476-like [ 160033]
  BaiE/LinA-like [ 160036] (5)
  Atu0742-like [ 160047]
  SEC-C associated NTF2-like domain [ 160050]


Superfamily statistics
Genomes (2,573) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 25,912 155,093 102
Proteins 25,394 151,641 102


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)macromolecule metabolic process10.4852Least InformativeInherited
Biological Process (BP)biological regulation11Least InformativeInherited
Biological Process (BP)macromolecule localization0.0000098630.0000000000005166Moderately InformativeDirect
Biological Process (BP)organic substance transport0.00048990.000000000004031Moderately InformativeDirect
Biological Process (BP)nitrogen compound transport0.000040510Moderately InformativeDirect
Biological Process (BP)cellular localization0.005180.00000009903Moderately InformativeInherited
Biological Process (BP)gene expression0.52620.02072Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.49931Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.36811Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.9071Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.12521Moderately InformativeInherited
Biological Process (BP)protein transport0.000021160InformativeDirect
Biological Process (BP)intracellular transport0.00045290.0000000000003793InformativeDirect
Biological Process (BP)secondary metabolic process0.00062390.01649InformativeInherited
Biological Process (BP)regulation of cellular amide metabolic process0.00012540.1805InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.017560.5843InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.015941InformativeInherited
Biological Process (BP)positive regulation of immune system process0.013110.3675InformativeInherited
Biological Process (BP)regulation of immune response0.0034550.2999InformativeInherited
Biological Process (BP)regulation of humoral immune response0.0006210.0002003Highly InformativeDirect
Biological Process (BP)nucleobase-containing compound transport0.000000190.00000000000002606Highly InformativeDirect
Biological Process (BP)antibiotic biosynthetic process0.0000001020.0000001066Highly InformativeDirect
Biological Process (BP)secondary metabolite biosynthetic process0.000097290.0007927Highly InformativeDirect
Biological Process (BP)establishment of RNA localization0.0000000000014970Highly InformativeDirect
Biological Process (BP)ribonucleoprotein complex localization0.000095530Highly InformativeDirect
Biological Process (BP)nuclear export0.34690.001951Highly InformativeInherited
Biological Process (BP)positive regulation of immune effector process0.000002050.002545Highly InformativeInherited
Biological Process (BP)regulation of production of molecular mediator of immune response0.0000089640.002718Highly InformativeInherited
Biological Process (BP)positive regulation of response to external stimulus0.000097290.03089Highly InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)protein complex10.3345Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.92690.2511Least InformativeInherited
Cellular Component (CC)nuclear part0.004570.006353Moderately InformativeInherited
Cellular Component (CC)endomembrane system0.11190.3847Moderately InformativeInherited
Cellular Component (CC)nuclear envelope0.000000000065290InformativeDirect
Cellular Component (CC)nuclear pore0.00017110.000000333Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.4852 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) macromolecule localization 0.0000000000005166 Moderately Informative Direct
Biological Process (BP) cellular localization 0.00000009903 Moderately Informative Direct
Biological Process (BP) organic substance transport 0.000000000004031 Moderately Informative Direct
Biological Process (BP) nitrogen compound transport 0 Moderately Informative Direct
Biological Process (BP) animal organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.03623 Moderately Informative Inherited
Biological Process (BP) gene expression 0.02072 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) mitochondrion organization 0.00000472 Informative Direct
Biological Process (BP) protein transport 0 Informative Direct
Biological Process (BP) phosphorylation 0.0000002377 Informative Direct
Biological Process (BP) intracellular transport 0.0000000000003793 Informative Direct
Biological Process (BP) protein localization to organelle 0.7951 Informative Inherited
Biological Process (BP) secondary metabolic process 0.01649 Informative Inherited
Biological Process (BP) circulatory system development 0.04204 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.1314 Informative Inherited
Biological Process (BP) regulation of system process 0.01405 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.8187 Informative Inherited
Biological Process (BP) epithelium development 0.8379 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.7109 Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 0.1805 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.5843 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.3675 Informative Inherited
Biological Process (BP) regulation of immune response 0.2999 Informative Inherited
Biological Process (BP) cell cycle process 0.9859 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.6156 Informative Inherited
Biological Process (BP) response to hypoxia 0.0002496 Highly Informative Direct
Biological Process (BP) regulation of humoral immune response 0.0002003 Highly Informative Direct
Biological Process (BP) mitochondrial transport 0.0007272 Highly Informative Direct
Biological Process (BP) nucleobase-containing compound transport 0.00000000000002606 Highly Informative Direct
Biological Process (BP) antibiotic biosynthetic process 0.0000001066 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0.0007927 Highly Informative Direct
Biological Process (BP) establishment of RNA localization 0 Highly Informative Direct
Biological Process (BP) ribonucleoprotein complex localization 0 Highly Informative Direct
Biological Process (BP) establishment of protein localization to mitochondrion 0.00005419 Highly Informative Direct
Biological Process (BP) heart development 0.001176 Highly Informative Inherited
Biological Process (BP) embryonic organ development 0.06168 Highly Informative Inherited
Biological Process (BP) protein targeting 0.7796 Highly Informative Inherited
Biological Process (BP) nuclear export 0.001951 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.1223 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.1413 Highly Informative Inherited
Biological Process (BP) positive regulation of immune effector process 0.002545 Highly Informative Inherited
Biological Process (BP) regulation of production of molecular mediator of immune response 0.002718 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.03089 Highly Informative Inherited
Biological Process (BP) mitotic cell cycle phase transition 0.003347 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 0.8163 Least Informative Inherited
Molecular Function (MF) transporter activity 0.9643 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.001001 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 0.1588 Moderately Informative Inherited
Molecular Function (MF) RNA binding 0.0000001775 Informative Direct
Molecular Function (MF) kinase activity 0.00004083 Informative Direct
Molecular Function (MF) P-P-bond-hydrolysis-driven transmembrane transporter activity 0.001242 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.003974 Informative Inherited
Molecular Function (MF) protein kinase activity 0.000278 Highly Informative Direct
Molecular Function (MF) protein transporter activity 0.00000002883 Highly Informative Direct
Molecular Function (MF) macromolecule transmembrane transporter activity 0.000000000005691 Highly Informative Direct
Molecular Function (MF) amide transmembrane transporter activity 0.00000000735 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 0.2511 Least Informative Inherited
Cellular Component (CC) protein complex 0.3345 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) organelle inner membrane 0.000002578 Moderately Informative Direct
Cellular Component (CC) mitochondrial protein complex 0.0001999 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.103 Moderately Informative Inherited
Cellular Component (CC) membrane protein complex 0.1934 Moderately Informative Inherited
Cellular Component (CC) mitochondrial envelope 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.3847 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.006353 Moderately Informative Inherited
Cellular Component (CC) ribosome 0.04216 Moderately Informative Inherited
Cellular Component (CC) nuclear envelope 0 Informative Direct
Cellular Component (CC) inner mitochondrial membrane protein complex 0.0001155 Informative Direct
Cellular Component (CC) nucleoplasm part 0.238 Informative Inherited
Cellular Component (CC) large ribosomal subunit 0.00151 Informative Inherited
Cellular Component (CC) nuclear pore 0.000000333 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.0002027Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.0006578Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000000002583Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processProtein transport0.0000000000006655Moderately InformativeDirect
Biological processVirulence0.00000006178Moderately InformativeDirect
Biological processDifferentiation0.0002772Moderately InformativeDirect
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processNeurogenesis0.0000003744InformativeDirect
Biological processmRNA transport0Highly InformativeDirect
Biological processAntibiotic biosynthesis4.848e-16Highly InformativeDirect
Cellular componentNucleus0.0000001068Least InformativeDirect
Cellular componentMitochondrion0.00005348Moderately InformativeDirect
Cellular componentSarcoplasmic reticulum0Highly InformativeDirect
DomainTransit peptide0.0000001437Moderately InformativeDirect
DomainLeucine-rich repeat0.000000000000002153InformativeDirect
Molecular functionNAD0.0000000001133Moderately InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationKinase0.00000634Moderately InformativeDirect
Post-translational modificationOxidoreductase0.000673Moderately InformativeDirect
Post-translational modificationCalmodulin-binding0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationDioxygenase0Highly InformativeDirect
Post-translational modificationPhosphoprotein0.0000005756Least InformativeDirect
Post-translational modificationAcetylation0.000003855Least InformativeDirect
Post-translational modificationMethylation0.0008826Moderately InformativeDirect
Post-translational modificationNitration0.00000002042InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 67 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a NTF2-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 67 hidden Markov models representing the NTF2-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]