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MHC antigen-recognition domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   MHC antigen-recognition domain [ 54451]
Superfamily:   MHC antigen-recognition domain [ 54452]
Family:   MHC antigen-recognition domain [ 54453] (12)


Family statistics
Genomes (65) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 2,875 69,430 190
Proteins 2,869 69,385 190


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.01255Least InformativeInherited
Disease Ontology (DO)organ system cancer0.07263Least InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.00000001975Moderately InformativeDirect
Disease Ontology (DO)disease by infectious agent0.0000004772Moderately InformativeDirect
Disease Ontology (DO)disease of metabolism0.000001213Moderately InformativeDirect
Disease Ontology (DO)hematopoietic system disease0.00001072Moderately InformativeDirect
Disease Ontology (DO)connective tissue disease0.00002395Moderately InformativeDirect
Disease Ontology (DO)gastrointestinal system disease0.0001528Moderately InformativeDirect
Disease Ontology (DO)integumentary system disease0.0006289Moderately InformativeDirect
Disease Ontology (DO)hematologic cancer0.00292Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.03188Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.03351Moderately InformativeInherited
Disease Ontology (DO)syndrome0.2779Moderately InformativeInherited
Disease Ontology (DO)multiple sclerosis0.0000000000006131InformativeDirect
Disease Ontology (DO)liver disease0.00000002503InformativeDirect
Disease Ontology (DO)Kawasaki disease0.0000001129InformativeDirect
Disease Ontology (DO)vasculitis0.000001332InformativeDirect
Disease Ontology (DO)hypotrichosis0.00004805InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.0003129InformativeDirect
Disease Ontology (DO)autosomal recessive disease0.0003588InformativeDirect
Disease Ontology (DO)arthropathy0.007326InformativeInherited
Disease Ontology (DO)bullous skin disease0.01245InformativeInherited
Disease Ontology (DO)upper respiratory tract disease0.04475InformativeInherited
Disease Ontology (DO)eye disease0.06102InformativeInherited
Disease Ontology (DO)myeloid leukemia0.06957InformativeInherited
Disease Ontology (DO)glucose metabolism disease1InformativeInherited
Disease Ontology (DO)Graves' disease0.00000000007061Highly InformativeDirect
Disease Ontology (DO)Behcet's disease0.00000005718Highly InformativeDirect
Disease Ontology (DO)psoriatic arthritis0.0000002171Highly InformativeDirect
Disease Ontology (DO)sickle cell anemia0.0000009922Highly InformativeDirect
Disease Ontology (DO)spondylitis0.000008751Highly InformativeDirect
Disease Ontology (DO)neuromyelitis optica0.00001489Highly InformativeDirect
Disease Ontology (DO)pemphigus0.00001789Highly InformativeDirect
Disease Ontology (DO)sarcoidosis0.00002391Highly InformativeDirect
Disease Ontology (DO)intrahepatic cholestasis0.00003804Highly InformativeDirect
Disease Ontology (DO)hemochromatosis0.0000627Highly InformativeDirect
Disease Ontology (DO)vascular hemostatic disease0.00007335Highly InformativeDirect
Disease Ontology (DO)uveitis0.0001274Highly InformativeDirect
Disease Ontology (DO)rheumatic fever0.0002952Highly InformativeDirect
Disease Ontology (DO)thyroid gland disease0.001791Highly InformativeInherited
Disease Ontology (DO)neuromuscular disease0.02601Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.05316Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.06687Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.06908Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.08874Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.1335Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.3475Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.5363Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.5724Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.6924Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal homeostasis0.003369Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.01639Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart morphology0.03537Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.03707Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thorax0.03885Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.04602Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.1091Moderately InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.1186Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.1225Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.1281Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.1655Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.2935Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating metabolite concentration0.3026Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.3359Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal vascular morphology0.3512Moderately InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0.3584Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.4154Moderately InformativeInherited
Phenotypic Abnormality (PA)Inflammatory abnormality of the eye0.00001402InformativeDirect
Phenotypic Abnormality (PA)Edema0.00004916InformativeDirect
Phenotypic Abnormality (PA)Weight loss0.00007448InformativeDirect
Phenotypic Abnormality (PA)Arrhythmia0.0003559InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skin physiology0.0004594InformativeDirect
Phenotypic Abnormality (PA)Unusual infection by anatomical site0.0004719InformativeDirect
Phenotypic Abnormality (PA)Pain0.003838InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the pancreas0.00689InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating protein level0.006921InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral vasculature0.0193InformativeInherited
Phenotypic Abnormality (PA)Abnormal systemic arterial morphology0.02937InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal morphology0.0506InformativeInherited
Phenotypic Abnormality (PA)Cognitive impairment0.05978InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.2647InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the pleura0.00000008557Highly InformativeDirect
Phenotypic Abnormality (PA)Pericarditis0.0000002231Highly InformativeDirect
Phenotypic Abnormality (PA)Meningitis0.000003253Highly InformativeDirect
Phenotypic Abnormality (PA)Cough0.000005166Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal sputum0.00001735Highly InformativeDirect
Phenotypic Abnormality (PA)Pulmonary infiltrates0.00001835Highly InformativeDirect
Phenotypic Abnormality (PA)Chest pain0.0000337Highly InformativeDirect
Phenotypic Abnormality (PA)Glomerulopathy0.00004684Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of pancreas physiology0.00007056Highly InformativeDirect
Phenotypic Abnormality (PA)Abdominal pain0.00007254Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal erythrocyte sedimentation rate0.00008267Highly InformativeDirect
Phenotypic Abnormality (PA)Vasculitis0.0001141Highly InformativeDirect
Phenotypic Abnormality (PA)Restrictive ventilatory defect0.0002117Highly InformativeDirect
Phenotypic Abnormality (PA)Diabetes insipidus0.0002724Highly InformativeDirect
Phenotypic Abnormality (PA)Fatigue0.0003784Highly InformativeDirect
Phenotypic Abnormality (PA)Venous thrombosis0.0004081Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal C-reactive protein level0.0005195Highly InformativeDirect
Phenotypic Abnormality (PA)Memory impairment0.0006598Highly InformativeDirect
Phenotypic Abnormality (PA)Cranial nerve paralysis0.0007144Highly InformativeDirect
Phenotypic Abnormality (PA)Skin ulcer0.0008908Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.0000002059Least InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte physiology0.000001904Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal T cell morphology0.00002677Moderately InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to infection0.0002449Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.07042Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.3981Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.6784Moderately InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.8046Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal antigen presentation0.0001441InformativeDirect
Mammalian Phenotype (MP)abnormal interferon-gamma secretion0.0004073InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to autoimmune disorder0.0008068InformativeDirect
Mammalian Phenotype (MP)abnormal CD8-positive, alpha beta T cell morphology0.08883InformativeInherited
Mammalian Phenotype (MP)abnormal innate immunity0.2009InformativeInherited
Mammalian Phenotype (MP)abnormal alpha-beta T cell number0.3197InformativeInherited
Mammalian Phenotype (MP)decreased T cell number0.3276InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.795InformativeInherited
Mammalian Phenotype (MP)abnormal cytotoxic T cell physiology0.0005594Highly InformativeDirect
Mammalian Phenotype (MP)decreased CD8-positive, alpha-beta T cell number0.4589Highly InformativeInherited

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0Least InformativeDirect
Xenopus ANatomical entity (XAN)alimentary system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)viscus0.2589Moderately InformativeInherited
Xenopus ANatomical entity (XAN)pancreas0.0003579Highly InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 92 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a MHC antigen-recognition domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Internal database links ]