SUPERFAMILY 1.75 HMM library and genome assignments server

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dsRNA-binding domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   dsRBD-like [ 54767] (5)
Superfamily:   dsRNA-binding domain-like [ 54768] (3)
Families:   Double-stranded RNA-binding domain (dsRBD) [ 54769] (12)
  The homologous-pairing domain of Rad52 recombinase [ 82645]
  Ribosomal S5 protein, N-terminal domain [ 54778]


Superfamily statistics
Genomes (3,262) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 17,227 78,579 40
Proteins 13,752 68,753 39


Functional annotation
General category Regulation
Detailed category RNA binding, metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Endoribonucleases producing 5'-phosphomonoesters0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease by infectious agent0.005954Moderately InformativeInherited
Disease Ontology (DO)viral infectious disease0.0003041InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the digestive system0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.01672Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.271Least InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.3324Moderately InformativeInherited
Mammalian Phenotype (MP)embryonic lethality prior to organogenesis0.0003819InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection0.01431InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.00621Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.01213Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1572Least InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.0004955Moderately InformativeDirect
Worm Phenotype (WP)neuron development variant0.01708Moderately InformativeInherited
Worm Phenotype (WP)maintenance of gene silencing variant0.0000002739InformativeDirect
Worm Phenotype (WP)RNA expression variant0.00002226InformativeDirect
Worm Phenotype (WP)pericellular component morphology variant0.0002992InformativeDirect
Worm Phenotype (WP)germ cell cytoplasmic morphology variant0.02794InformativeInherited
Worm Phenotype (WP)neurite development variant0.00002555Highly InformativeDirect
Worm Phenotype (WP)alae morphology variant0.00004036Highly InformativeDirect
Worm Phenotype (WP)cytoplasmic processing body variant0.0006483Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)radiation resistance0.0007291Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)multi-tissue structure0.00506Least InformativeInherited
Fly Anatomy (FA)nervous system0.4199Least InformativeInherited
Fly Anatomy (FA)adult0.4804Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.4844Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)somatic cell1Least InformativeInherited
Fly Anatomy (FA)gonad0.0001622Moderately InformativeDirect
Fly Anatomy (FA)central nervous system0.04038Moderately InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.0626Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system0.08356Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.1128Moderately InformativeInherited
Fly Anatomy (FA)neuron0.1186Moderately InformativeInherited
Fly Anatomy (FA)head0.1188Moderately InformativeInherited
Fly Anatomy (FA)portion of tissue0.1351Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.1649Moderately InformativeInherited
Fly Anatomy (FA)stem cell0.2858Moderately InformativeInherited
Fly Anatomy (FA)adult tagma0.3145Moderately InformativeInherited
Fly Anatomy (FA)germline cell0.0004859InformativeDirect
Fly Anatomy (FA)ovariole0.001073InformativeInherited
Fly Anatomy (FA)adult central nervous system0.004706InformativeInherited
Fly Anatomy (FA)synaptic neuropil0.009887InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.02055InformativeInherited
Fly Anatomy (FA)neuromere0.1205InformativeInherited
Fly Anatomy (FA)interneuron0.1319InformativeInherited
Fly Anatomy (FA)brain0.1901InformativeInherited
Fly Anatomy (FA)antennal lobe projection neuron adPN0.00007528Highly InformativeDirect
Fly Anatomy (FA)unilateral ACT relay interneuron0.0001149Highly InformativeDirect
Fly Anatomy (FA)antennal lobe projection neuron iPN0.0001149Highly InformativeDirect
Fly Anatomy (FA)female germline stem cell0.0001243Highly InformativeDirect
Fly Anatomy (FA)cholinergic neuron0.0001483Highly InformativeDirect
Fly Anatomy (FA)neuroblast lineage clone0.0004894Highly InformativeDirect
Fly Anatomy (FA)mushroom body intrinsic neuron0.0007863Highly InformativeDirect
Fly Anatomy (FA)supraesophageal ganglion neuron0.01008Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Endoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)In cyclic amidines0.3789InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a dsRNA-binding domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 26 hidden Markov models representing the dsRNA-binding domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]