SUPERFAMILY 1.75 HMM library and genome assignments server

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dsRNA-binding domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   dsRBD-like [ 54767] (5)
Superfamily:   dsRNA-binding domain-like [ 54768] (3)
Families:   Double-stranded RNA-binding domain (dsRBD) [ 54769] (12)
  The homologous-pairing domain of Rad52 recombinase [ 82645]
  Ribosomal S5 protein, N-terminal domain [ 54778]


Superfamily statistics
Genomes (3,262) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 17,227 78,579 40
Proteins 13,752 68,753 39


Functional annotation
General category Regulation
Detailed category RNA binding, metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Endoribonucleases producing 5'-phosphomonoesters0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease by infectious agent0.005952Moderately InformativeInherited
Disease Ontology (DO)viral infectious disease0.0003038InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the digestive system0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.01669Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.2708Least InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.3322Moderately InformativeInherited
Mammalian Phenotype (MP)embryonic lethality prior to organogenesis0.0003785InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection0.01431InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.004865Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.03139Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.2047Least InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.003236Moderately InformativeInherited
Worm Phenotype (WP)maintenance of gene silencing variant0.0000000001968InformativeDirect
Worm Phenotype (WP)RNA expression variant0.00002248InformativeDirect
Worm Phenotype (WP)pericellular component morphology variant0.0003036InformativeDirect
Worm Phenotype (WP)germ cell cytoplasmic morphology variant0.07316InformativeInherited
Worm Phenotype (WP)neurite development variant0.00002198Highly InformativeDirect
Worm Phenotype (WP)alae morphology variant0.00003818Highly InformativeDirect
Worm Phenotype (WP)cytoplasmic processing body variant0.0006254Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)radiation resistance0.0007291Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)multi-tissue structure0.004779Least InformativeInherited
Fly Anatomy (FA)nervous system0.4034Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.4771Least InformativeInherited
Fly Anatomy (FA)adult0.4783Least InformativeInherited
Fly Anatomy (FA)somatic cell0.9965Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)gonad0.0001625Moderately InformativeDirect
Fly Anatomy (FA)central nervous system0.03854Moderately InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.05943Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system0.08214Moderately InformativeInherited
Fly Anatomy (FA)neuron0.1097Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.1138Moderately InformativeInherited
Fly Anatomy (FA)head0.117Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.1605Moderately InformativeInherited
Fly Anatomy (FA)stem cell0.2878Moderately InformativeInherited
Fly Anatomy (FA)germline cell0.0005214InformativeDirect
Fly Anatomy (FA)adult central nervous system0.004769InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.02146InformativeInherited
Fly Anatomy (FA)germarium0.03034InformativeInherited
Fly Anatomy (FA)interneuron0.03414InformativeInherited
Fly Anatomy (FA)neuromere0.1178InformativeInherited
Fly Anatomy (FA)labral segment0.1347InformativeInherited
Fly Anatomy (FA)brain0.1832InformativeInherited
Fly Anatomy (FA)antennal lobe projection neuron adPN0.00008572Highly InformativeDirect
Fly Anatomy (FA)female germline stem cell0.0001229Highly InformativeDirect
Fly Anatomy (FA)unilateral ACT relay interneuron0.0001287Highly InformativeDirect
Fly Anatomy (FA)antennal lobe projection neuron iPN0.0001287Highly InformativeDirect
Fly Anatomy (FA)cholinergic neuron0.0001457Highly InformativeDirect
Fly Anatomy (FA)mushroom body intrinsic neuron0.0004463Highly InformativeDirect
Fly Anatomy (FA)neuroblast lineage clone0.0005302Highly InformativeDirect
Fly Anatomy (FA)supraesophageal ganglion neuron0.007968Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Endoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)In cyclic amidines0.38InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a dsRNA-binding domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 26 hidden Markov models representing the dsRNA-binding domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]