SUPERFAMILY 1.75 HMM library and genome assignments server

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dsRNA-binding domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   dsRBD-like [ 54767] (5)
Superfamily:   dsRNA-binding domain-like [ 54768] (3)
Families:   Double-stranded RNA-binding domain (dsRBD) [ 54769] (12)
  The homologous-pairing domain of Rad52 recombinase [ 82645]
  Ribosomal S5 protein, N-terminal domain [ 54778]


Superfamily statistics
Genomes (3,262) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 17,227 78,579 40
Proteins 13,752 68,753 39


Functional annotation
General category Regulation
Detailed category RNA binding, metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Endoribonucleases producing 5'-phosphomonoesters0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease by infectious agent0.005891Moderately InformativeInherited
Disease Ontology (DO)viral infectious disease0.0002973InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.01662Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.271Least InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection0.02591Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.3328Moderately InformativeInherited
Mammalian Phenotype (MP)embryonic lethality prior to organogenesis0.0003751InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection0.01432InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.005058Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.00796Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.2055Least InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.003348Moderately InformativeInherited
Worm Phenotype (WP)maintenance of gene silencing variant0.0000000001904InformativeDirect
Worm Phenotype (WP)RNA expression variant0.00002408InformativeDirect
Worm Phenotype (WP)germ cell cytoplasmic morphology variant0.07722InformativeInherited
Worm Phenotype (WP)dendrite development variant0.000000663Highly InformativeDirect
Worm Phenotype (WP)alae morphology variant0.00004152Highly InformativeDirect
Worm Phenotype (WP)cytoplasmic processing body variant0.0006997Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)radiation resistance0.000724Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0.1253Moderately InformativeInherited
Fly Phenotype (FP)neurophysiology defective0.0009212InformativeDirect
Fly Phenotype (FP)mating defective0.003838Highly InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)multi-tissue structure0.00676Least InformativeInherited
Fly Anatomy (FA)anatomical group0.2298Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.2667Least InformativeInherited
Fly Anatomy (FA)nervous system0.2875Least InformativeInherited
Fly Anatomy (FA)adult0.3642Least InformativeInherited
Fly Anatomy (FA)somatic cell0.8717Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)gonad0.0004916Moderately InformativeDirect
Fly Anatomy (FA)central nervous system0.02362Moderately InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.04652Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system0.06297Moderately InformativeInherited
Fly Anatomy (FA)neuron0.06498Moderately InformativeInherited
Fly Anatomy (FA)head0.08649Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.09729Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.1113Moderately InformativeInherited
Fly Anatomy (FA)adult brain0.002366InformativeInherited
Fly Anatomy (FA)synaptic neuropil0.006007InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.02491InformativeInherited
Fly Anatomy (FA)interneuron0.03492InformativeInherited
Fly Anatomy (FA)supraesophageal ganglion0.09005InformativeInherited
Fly Anatomy (FA)neuromere0.1033InformativeInherited
Fly Anatomy (FA)antennal lobe projection neuron adPN0.000064Highly InformativeDirect
Fly Anatomy (FA)unilateral ACT relay interneuron0.00008475Highly InformativeDirect
Fly Anatomy (FA)antennal lobe projection neuron iPN0.00008475Highly InformativeDirect
Fly Anatomy (FA)mushroom body intrinsic neuron0.0002835Highly InformativeDirect
Fly Anatomy (FA)cholinergic neuron0.0003388Highly InformativeDirect
Fly Anatomy (FA)adult MBp lineage neuron0.001993Highly InformativeInherited
Fly Anatomy (FA)supraesophageal ganglion neuron0.008315Highly InformativeInherited
Fly Anatomy (FA)adult mushroom body0.1324Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)head0Moderately InformativeDirect
Zebrafish Anatomy (ZA)anatomical cluster0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Endoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)In cyclic amidines0.3772InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 24 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a dsRNA-binding domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 24 hidden Markov models representing the dsRNA-binding domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]