SUPERFAMILY 1.75 HMM library and genome assignments server

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dsRNA-binding domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   dsRBD-like [ 54767] (5)
Superfamily:   dsRNA-binding domain-like [ 54768] (3)
Families:   Double-stranded RNA-binding domain (dsRBD) [ 54769] (12)
  The homologous-pairing domain of Rad52 recombinase [ 82645]
  Ribosomal S5 protein, N-terminal domain [ 54778]


Superfamily statistics
Genomes (3,262) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 17,227 78,579 40
Proteins 13,752 68,753 39


Functional annotation
General category Regulation
Detailed category RNA binding, metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Endoribonucleases producing 5'-phosphomonoesters0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease by infectious agent0.005954Moderately InformativeInherited
Disease Ontology (DO)viral infectious disease0.0003041InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the digestive system0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.01673Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.2708Least InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.3324Moderately InformativeInherited
Mammalian Phenotype (MP)embryonic lethality prior to organogenesis0.0003819InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection0.0143InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.006223Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.01226Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1581Least InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.0005011Moderately InformativeDirect
Worm Phenotype (WP)neuron development variant0.0172Moderately InformativeInherited
Worm Phenotype (WP)maintenance of gene silencing variant0.000000277InformativeDirect
Worm Phenotype (WP)RNA expression variant0.00002169InformativeDirect
Worm Phenotype (WP)pericellular component morphology variant0.0003016InformativeDirect
Worm Phenotype (WP)germ cell cytoplasmic morphology variant0.02799InformativeInherited
Worm Phenotype (WP)neurite development variant0.0000258Highly InformativeDirect
Worm Phenotype (WP)alae morphology variant0.0000407Highly InformativeDirect
Worm Phenotype (WP)cytoplasmic processing body variant0.0006533Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)radiation resistance0.0007291Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)multi-tissue structure0.00495Least InformativeInherited
Fly Anatomy (FA)nervous system0.4257Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.4824Least InformativeInherited
Fly Anatomy (FA)adult0.4985Least InformativeInherited
Fly Anatomy (FA)larva0.8605Least InformativeInherited
Fly Anatomy (FA)somatic cell0.9994Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)gonad0.000157Moderately InformativeDirect
Fly Anatomy (FA)central nervous system0.0413Moderately InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.06426Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.1099Moderately InformativeInherited
Fly Anatomy (FA)head0.1188Moderately InformativeInherited
Fly Anatomy (FA)neuron0.1213Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.1673Moderately InformativeInherited
Fly Anatomy (FA)stem cell0.2923Moderately InformativeInherited
Fly Anatomy (FA)germline cell0.0004668InformativeDirect
Fly Anatomy (FA)ovariole0.001037InformativeInherited
Fly Anatomy (FA)adult central nervous system0.005559InformativeInherited
Fly Anatomy (FA)synaptic neuropil0.01025InformativeInherited
Fly Anatomy (FA)interneuron0.03637InformativeInherited
Fly Anatomy (FA)neuromere0.1228InformativeInherited
Fly Anatomy (FA)labral segment0.1625InformativeInherited
Fly Anatomy (FA)brain0.1948InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.2736InformativeInherited
Fly Anatomy (FA)female germline stem cell0.0001199Highly InformativeDirect
Fly Anatomy (FA)unilateral ACT relay interneuron0.0001261Highly InformativeDirect
Fly Anatomy (FA)cholinergic neuron0.0005084Highly InformativeDirect
Fly Anatomy (FA)neuroblast lineage clone0.0005182Highly InformativeDirect
Fly Anatomy (FA)mushroom body intrinsic neuron0.0007608Highly InformativeDirect
Fly Anatomy (FA)supraesophageal ganglion neuron0.01079Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Endoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)In cyclic amidines0.3782InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a dsRNA-binding domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 26 hidden Markov models representing the dsRNA-binding domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]