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Dimeric alpha+beta barrel superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ferredoxin-like [ 54861] (59)
Superfamily:   Dimeric alpha+beta barrel [ 54909] (23)
Families:   Actinorhodin biosynthesis monooxygenase ActVa-Orf6 [ 82666]
  Plant stress-induced protein [ 89927] (3)
  PG130-like [ 102959] (5)
  Hypothetical protein YjcS [ 102962]
  YciI-like [ 102965]
  Muconalactone isomerase, MLI [ 54910]
  Lrp/AsnC-like transcriptional regulator C-terminal domain [ 69733] (4)
  Polyketide synthesis cyclase [ 110959]
  DGPF domain (Pfam 04946) [ 110962]
  Chlorite dismutase-like [ 110965] (2)
  PA3566-like [ 110970] (5)
  Hypothetical protein YdhR [ 117940]
  NIPSNAP [ 117943] (2)
  Dyp-type peroxidase-like [ 143265] (3)
  EthD-like [ 143272]
  Atu0297-like [ 143275]
  SOR-like [ 143278]
  YbaA-like [ 160289]
  MmlI-like [ 160292]
  Marine metagenome family DABB2 [ 160295]
  YiiL-like [ 160298]
  Marine metagenome family DABB1 [ 160301] (2)
  Marine metagenome family DABB3 [ 160306]

Superfamily statistics
Genomes (2,669) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 29,069 195,785 47
Proteins 27,717 189,841 47

Functional annotation
General category Metabolism
Detailed category Secondary metabolism

Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details) Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.2598 Moderately Informative Inherited
Molecular Function (MF) tetrapyrrole binding 0.00001101 Informative Direct
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0.07833 Informative Inherited
Molecular Function (MF) heme binding 0.00000799 Highly Informative Direct
Molecular Function (MF) peroxidase activity 0.00001265 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.2323Least InformativeInherited
Enzyme Commission (EC)Racemases and epimerases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.000000000000005545Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbohydrates and derivatives0InformativeDirect
Enzyme Commission (EC)Miscellaneous (requires further characterization)0InformativeDirect
Enzyme Commission (EC)Transposing C==C bonds0.0000000001622InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processAromatic hydrocarbons catabolism0.00000002831InformativeDirect
Biological processAntibiotic biosynthesis0.000002704Highly InformativeDirect
Cellular componentPeriplasm0.0000000105InformativeDirect
Molecular functionMetal-binding0.003652Least InformativeInherited
Molecular functionIron0Moderately InformativeDirect
Molecular functionHeme0InformativeDirect
Post-translational modificationIsomerase0Moderately InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationDNA-binding0.000000000000006069Moderately InformativeDirect
Post-translational modificationActivator0.00000002539Moderately InformativeDirect
Post-translational modificationRepressor0.0004555Moderately InformativeDirect
Post-translational modificationPeroxidase0Highly InformativeDirect
Post-translational modificationMonooxygenase0.0000002865Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011008 SSF54909 Protein matches

Dimeric alpha-beta barrel domains exhibit an alpha+beta sandwich fold with an antiparallel beta sheet that forms a closed barrel. These domains dimerise through the beta-sheet, and in some cases these dimers may assemble into higher oligomers. Domains with this structure are found in proteins from several different families, including bacterial actinorhodin biosynthesis monooxygenase (ActVa-Orf6), which catalyses the oxidation of an aromatic intermediate of the actinorhodin biosynthetic pathway [PubMed12514126]; bacterial muconalactone isomerase, a decamer composed of five dimers [PubMed2926818]; and the C-terminal domain of archaeal LprA, a member of the Lrp/AqsnC family of transcription regulators [PubMed11230123].

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 41 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Dimeric alpha+beta barrel domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 41 hidden Markov models representing the Dimeric alpha+beta barrel superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]