SUPERFAMILY 1.75 HMM library and genome assignments server

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Acylphosphatase/BLUF domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ferredoxin-like [ 54861] (59)
Superfamily:   Acylphosphatase/BLUF domain-like [ 54975] (2)
Families:   Acylphosphatase-like [ 54976] (3)
  BLUF domain [ 143364] (3)

Superfamily statistics
Genomes (2,261) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 3,622 19,408 11
Proteins 3,618 19,382 11

Functional annotation
General category Regulation
Detailed category Kinases/phosphatases

Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Molecular Function (MF)hydrolase activity0.000038240.04723Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides0.0000000033480.000002659Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Molecular Function (MF) hydrolase activity 0.04723 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.000002659 Moderately Informative Direct
Cellular Component (CC) cell projection 0.000000001077 Moderately Informative Direct
Cellular Component (CC) cilium 0 Informative Direct
Cellular Component (CC) motile cilium 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentCell projection0.0000004439Moderately InformativeDirect
Cellular componentCilium0.0000000000001193InformativeDirect
Cellular componentFlagellum0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationReceptor0.546Moderately InformativeInherited
Post-translational modificationPhotoreceptor protein0.0000004794Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001792 SSF54975 Protein matches

Acylphosphatase is an enzyme of approximately 98 amino acid residues that specifically catalyses the hydrolysis of the carboxyl-phosphate bond of acylphosphates [PubMed1664426], its substrates including 1,3-diphosphoglycerate and carbamyl phosphate [PubMed2538623]. The enzyme has a mainly beta-sheet structure with 2 short alpha-helical segments. It is distributed in a tissue-specific manner in a wide variety of species, although its physiological role is as yet unknown [PubMed2538623]: it may, however, play a part in the regulation of the glycolytic pathway and pyrimidine biosynthesis [PubMed2830253]. There are two known isozymes. One seems to be specific to muscular tissues, the other, called 'organ-common type', is found in many different tissues. While bacterial and archebacterial hypothetical proteins that are highly similar to that enzyme and that probably possess the same activity.

These proteins include:

  • Escherichia coli putative acylphosphatase (acylphosphate phosphohydrolase) (gene yccX).
  • Bacillus subtilis putative acylphosphatase (acylphosphate phosphohydrolase) (gene yflL).
  • Archaeoglobus fulgidus hypothetical protein AF0818.

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Acylphosphatase/BLUF domain-like domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the Acylphosphatase/BLUF domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]