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Bacterial exopeptidase dimerisation domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ferredoxin-like [ 54861] (59)
Superfamily:   Bacterial exopeptidase dimerisation domain [ 55031]
Families:   Bacterial exopeptidase dimerisation domain [ 55032] (8)


Superfamily statistics
Genomes (2,999) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 15,949 98,799 10
Proteins 15,927 98,741 10


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) organonitrogen compound metabolic process 0.00000000001407 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.0004876 Least Informative Direct
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.8154 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.4599 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.9724 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.9651 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.0000000002707 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.00003226 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.2015 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.08444 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.4225 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.3178 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.004736 Moderately Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.0000000000005804 Informative Direct
Biological Process (BP) proteolysis 0.00000002332 Informative Direct
Biological Process (BP) regulation of transmembrane transport 0.000005489 Informative Direct
Biological Process (BP) regulation of ion transport 0.0001095 Informative Direct
Biological Process (BP) glutamine family amino acid metabolic process 0.001354 Informative Inherited
Biological Process (BP) arginine metabolic process 0.00000000000007943 Highly Informative Direct
Biological Process (BP) multicellular organism metabolic process 0.0000000002014 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transporter activity 0.0000002515 Highly Informative Direct
Biological Process (BP) multicellular organismal homeostasis 0.000007576 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0 Informative Direct
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.8941 Informative Inherited
Molecular Function (MF) deacetylase activity 0.000000001605 Highly Informative Direct
Molecular Function (MF) exopeptidase activity 0.000000008442 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.000000072Least InformativeDirect
Enzyme Commission (EC)In linear amides0Moderately InformativeDirect
Enzyme Commission (EC)Aminopeptidases0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processLysine biosynthesis0Highly InformativeDirect
Biological processDiaminopimelate biosynthesis0Highly InformativeDirect
Biological processPurine metabolism0.00000000171Highly InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionCobalt0InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtease0.00000000000001546Moderately InformativeDirect
Post-translational modificationMetalloprotease0InformativeDirect
Post-translational modificationAminopeptidase0Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011650 SSF55031 Protein matches
Abstract This domain consists of 4 beta strands and two alpha helices which make up the dimerisation surface of members of the MEROPS peptidase family M20 [PubMed9083113]. This family includes a range of zinc exopeptidases: carboxypeptidases, dipeptidases and specialised aminopeptidases [PubMed7674922].

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Bacterial exopeptidase dimerisation domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Bacterial exopeptidase dimerisation domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]