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Translation initiation factor IF3, C-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   IF3-like [ 55199] (8)
Superfamily:   Translation initiation factor IF3, C-terminal domain [ 55200]
Families:   Translation initiation factor IF3, C-terminal domain [ 55201]


Superfamily statistics
Genomes (2,916) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 3,118 17,310 3
Proteins 3,115 17,304 3


Functional annotation
General category Information
Detailed category Translation

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0.0006474 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.00854 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.001364 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.00789 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.3763 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.06567 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.01266 Least Informative Inherited
Biological Process (BP) peptide metabolic process 0.00000001599 Moderately Informative Direct
Biological Process (BP) organelle organization 0.000209 Moderately Informative Direct
Biological Process (BP) gene expression 0.00000967 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0.000004094 Moderately Informative Direct
Biological Process (BP) amide biosynthetic process 0.00000001302 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.000537 Moderately Informative Direct
Biological Process (BP) ribonucleoprotein complex subunit organization 0.000000001482 Informative Direct
Biological Process (BP) translational initiation 0.00000000000005222 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.00000000132 Highly Informative Direct
Biological Process (BP) mitochondrial gene expression 0.0000009198 Highly Informative Direct
Molecular Function (MF) binding 0.0195 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0.00001066 Moderately Informative Direct
Molecular Function (MF) RNA binding 0.00000001242 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.00000004955 Informative Direct
Molecular Function (MF) translation factor activity, RNA binding 8.27e-16 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.00008451 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.001207 Least Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processProtein biosynthesis0InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Post-translational modificationInitiation factor0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001288 SSF55200 Protein matches
Abstract

Initiation factor 3 (IF-3) (gene infC) is one of the three factors required for the initiation of protein biosynthesis in bacteria. IF-3 is thought to function as a fidelity factor during the assembly of the ternary initiation complex which consist of the 30S ribosomal subunit, the initiator tRNA and the messenger RNA. IF-3 is a basic protein that binds to the 30S ribosomal subunit [PubMed8405963]. The chloroplast initiation factor IF-3(chl) is a protein that enhances the poly(A,U,G)-dependent binding of the initiator tRNA to chloroplast ribosomal 30s subunits in which the central section is evolutionary related to the sequence of bacterial IF-3 [PubMed8144528].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Translation initiation factor IF3, C-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Translation initiation factor IF3, C-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]