SUPERFAMILY 1.75 HMM library and genome assignments server

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Tubulin, C-terminal domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Bacillus chorismate mutase-like [ 55297] (9)
Superfamily:   Tubulin C-terminal domain-like [ 55307]
Family:   Tubulin, C-terminal domain [ 55308] (3)


Family statistics
Genomes (2,779) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 8,262 45,706 19
Proteins 8,250 45,583 19


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of mental health0.01355Moderately InformativeInherited
Disease Ontology (DO)schizophrenia0.0007274InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.0001573Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.1682Least InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0.03479Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebrum0.06097Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral ventricles0.008237InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of the brainstem0.000000659Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal cortical gyration0.000004221Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of lateral ventricle0.0008668Highly InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0003859Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.000502Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.00131Least InformativeInherited
Worm Phenotype (WP)cell development variant0.005418Least InformativeInherited
Worm Phenotype (WP)protein protein interaction variant0.000000002011Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.000009275Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.0001481Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.00707Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.01244Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.05026Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.1316Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.7014Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.9092Moderately InformativeInherited
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.00000000866InformativeDirect
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.00000008177InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.00001237InformativeDirect
Worm Phenotype (WP)cytokinesis variant emb0.0002417InformativeDirect
Worm Phenotype (WP)cell migration variant0.0003915InformativeDirect
Worm Phenotype (WP)mitosis variant0.0005361InformativeDirect
Worm Phenotype (WP)cell component localization variant0.001145InformativeInherited
Worm Phenotype (WP)gonad development variant0.01416InformativeInherited
Worm Phenotype (WP)epithelial system development variant0.02011InformativeInherited
Worm Phenotype (WP)RNA expression variant0.1158InformativeInherited
Worm Phenotype (WP)locomotion reduced0.6412InformativeInherited
Worm Phenotype (WP)egg laying variant0.6824InformativeInherited
Worm Phenotype (WP)pronucleus centrosomes defective early emb0.000000000001471Highly InformativeDirect
Worm Phenotype (WP)RAB-11 recycling endosome localization variant0.00000008269Highly InformativeDirect
Worm Phenotype (WP)miRNA expression variant0.000001451Highly InformativeDirect
Worm Phenotype (WP)cuticle morphology variant0.00001957Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.00002144Highly InformativeDirect
Worm Phenotype (WP)sluggish0.0000528Highly InformativeDirect
Worm Phenotype (WP)male mating variant0.0001686Highly InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.0002974Highly InformativeDirect
Worm Phenotype (WP)male somatic gonad development variant0.0004219Highly InformativeDirect
Worm Phenotype (WP)gonad arm morphology variant0.000739Highly InformativeDirect
Worm Phenotype (WP)synapse morphology variant0.008009Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)fertile0.08901Moderately InformativeInherited
Fly Phenotype (FP)male fertile0.0000005911Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)somatic cell0.9694Least InformativeInherited
Fly Anatomy (FA)gonad0.000578Moderately InformativeDirect
Fly Anatomy (FA)somatic precursor cell0.05718Moderately InformativeInherited
Fly Anatomy (FA)germline cell0.0004714InformativeDirect
Fly Anatomy (FA)male organism0.003713InformativeInherited
Fly Anatomy (FA)somatic stem cell0.3418InformativeInherited
Fly Anatomy (FA)type I neuroblast0.000002831Highly InformativeDirect
Fly Anatomy (FA)spermatid0.00001199Highly InformativeDirect
Fly Anatomy (FA)type II neuroblast0.00001222Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)sensory system0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

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XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.005033Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.07038Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.1139Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.1449Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.7579Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.00002749Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.003917Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.03515Moderately InformativeInherited
Xenopus ANatomical entity (XAN)epithelium0.000001398InformativeDirect
Xenopus ANatomical entity (XAN)dermal system0.00008823InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.0006892InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.1052InformativeInherited
Xenopus ANatomical entity (XAN)spinal cord0.1811InformativeInherited
Xenopus ANatomical entity (XAN)cell part0.000000000000007789Highly InformativeDirect
Xenopus ANatomical entity (XAN)ciliated cell0.00000000000004724Highly InformativeDirect
Xenopus ANatomical entity (XAN)epithelial cell0.0000000000914Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.000000003676Highly InformativeDirect
Xenopus ANatomical entity (XAN)epidermis0.000004932Highly InformativeDirect
Xenopus ANatomical entity (XAN)vegetal hemisphere0.0001605Highly InformativeDirect
Xenopus ANatomical entity (XAN)archenteron0.001194Highly InformativeInherited
Xenopus ANatomical entity (XAN)intersomitic region0.009Highly InformativeInherited
Xenopus ANatomical entity (XAN)cranial nerve1Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)vascular system0.004079InformativeInherited

Document: AP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 15 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Tubulin C-terminal domain-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]