SUPERFAMILY 1.75 HMM library and genome assignments server

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Tubulin, C-terminal domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Bacillus chorismate mutase-like [ 55297] (9)
Superfamily:   Tubulin C-terminal domain-like [ 55307]
Family:   Tubulin, C-terminal domain [ 55308] (3)


Family statistics
Genomes (2,779) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 8,262 45,706 19
Proteins 8,250 45,583 19


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of mental health0.01355Moderately InformativeInherited
Disease Ontology (DO)schizophrenia0.0007274InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.0001565Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.1684Least InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0.03475Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebrum0.06089Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral ventricles0.008229InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of the brainstem0.0000006594Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal cortical gyration0.000004214Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of lateral ventricle0.000867Highly InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0003922Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.0005102Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.001316Least InformativeInherited
Worm Phenotype (WP)cell development variant0.005452Least InformativeInherited
Worm Phenotype (WP)protein protein interaction variant0.000000002048Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.000009387Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.0001487Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.00712Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.01234Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.05024Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.1315Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.7016Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.9081Moderately InformativeInherited
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.000000008771InformativeDirect
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.00000008267InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.00001247InformativeDirect
Worm Phenotype (WP)cytokinesis variant emb0.0002432InformativeDirect
Worm Phenotype (WP)cell migration variant0.0003932InformativeDirect
Worm Phenotype (WP)mitosis variant0.0005244InformativeDirect
Worm Phenotype (WP)cell component localization variant0.001149InformativeInherited
Worm Phenotype (WP)gonad development variant0.01408InformativeInherited
Worm Phenotype (WP)epithelial system development variant0.0202InformativeInherited
Worm Phenotype (WP)RNA expression variant0.1159InformativeInherited
Worm Phenotype (WP)locomotion reduced0.6413InformativeInherited
Worm Phenotype (WP)egg laying variant0.6824InformativeInherited
Worm Phenotype (WP)pronucleus centrosomes defective early emb0.00000000000149Highly InformativeDirect
Worm Phenotype (WP)RAB-11 recycling endosome localization variant0.0000000835Highly InformativeDirect
Worm Phenotype (WP)miRNA expression variant0.000001461Highly InformativeDirect
Worm Phenotype (WP)cuticle morphology variant0.0000197Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.00002163Highly InformativeDirect
Worm Phenotype (WP)sluggish0.00005316Highly InformativeDirect
Worm Phenotype (WP)male mating variant0.0001697Highly InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.0002972Highly InformativeDirect
Worm Phenotype (WP)male somatic gonad development variant0.0004241Highly InformativeDirect
Worm Phenotype (WP)gonad arm morphology variant0.0007427Highly InformativeDirect
Worm Phenotype (WP)synapse morphology variant0.008028Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

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FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)fertile0.08819Moderately InformativeInherited
Fly Phenotype (FP)male fertile0.0000005896Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)somatic cell0.9704Least InformativeInherited
Fly Anatomy (FA)gonad0.0005495Moderately InformativeDirect
Fly Anatomy (FA)developing material anatomical entity0.09246Moderately InformativeInherited
Fly Anatomy (FA)germline cell0.0004814InformativeDirect
Fly Anatomy (FA)male-specific anatomical entity0.002844InformativeInherited
Fly Anatomy (FA)fat body0.01817InformativeInherited
Fly Anatomy (FA)somatic stem cell0.3397InformativeInherited
Fly Anatomy (FA)fat cell0.00000272Highly InformativeDirect
Fly Anatomy (FA)type I neuroblast0.00000272Highly InformativeDirect
Fly Anatomy (FA)spermatid0.00001136Highly InformativeDirect
Fly Anatomy (FA)type II neuroblast0.00001172Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

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ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)sensory system0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

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XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.005035Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.0702Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.1139Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.1445Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.7578Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.00002749Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.003916Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.03501Moderately InformativeInherited
Xenopus ANatomical entity (XAN)epithelium0.000001432InformativeDirect
Xenopus ANatomical entity (XAN)dermal system0.00008823InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.000693InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.106InformativeInherited
Xenopus ANatomical entity (XAN)spinal cord0.1836InformativeInherited
Xenopus ANatomical entity (XAN)cell part0.00000000000000779Highly InformativeDirect
Xenopus ANatomical entity (XAN)ciliated cell0.00000000000004725Highly InformativeDirect
Xenopus ANatomical entity (XAN)epithelial cell0.00000000009142Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.000000003676Highly InformativeDirect
Xenopus ANatomical entity (XAN)epidermis0.000004933Highly InformativeDirect
Xenopus ANatomical entity (XAN)vegetal hemisphere0.0001605Highly InformativeDirect
Xenopus ANatomical entity (XAN)archenteron0.001301Highly InformativeInherited
Xenopus ANatomical entity (XAN)intersomitic region0.008999Highly InformativeInherited
Xenopus ANatomical entity (XAN)cranial nerve1Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)vascular system0.004079InformativeInherited

Document: AP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 15 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Tubulin C-terminal domain-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]