SUPERFAMILY 1.75 HMM library and genome assignments server

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eIF4e-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   eIF4e-like [ 55417]
Superfamily:   eIF4e-like [ 55418] (2)
Families:   Translation initiation factor eIF4e [ 55419]
  BLES03-like [ 143583]


Superfamily statistics
Genomes (521) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 2,282 6,022 6
Proteins 2,264 5,976 6


Functional annotation
General category Information
Detailed category Translation

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular nitrogen compound metabolic process0.58880.5906Least InformativeInherited
Biological Process (BP)multicellular organismal process0.56151Least InformativeInherited
Biological Process (BP)biological regulation0.43221Least InformativeInherited
Biological Process (BP)biosynthetic process0.66110.3863Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process0.93780.9822Least InformativeInherited
Biological Process (BP)macromolecule metabolic process0.63361Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)peptide metabolic process0.0000040860.000001046Moderately InformativeDirect
Biological Process (BP)amide biosynthetic process0.000015080.0000007647Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process0.000015790.0002023Moderately InformativeDirect
Biological Process (BP)negative regulation of metabolic process0.070650.2414Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.34671Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.00000049750.06301Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.000016580.04104Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.00000093620.06798Moderately InformativeInherited
Biological Process (BP)gene expression0.0018430.007348Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.000650.002581Moderately InformativeInherited
Biological Process (BP)regulation of cellular amide metabolic process00.0000000000002933InformativeDirect
Biological Process (BP)posttranscriptional regulation of gene expression0.000000000000083520.000000000001705InformativeDirect
Biological Process (BP)negative regulation of gene expression0.052170.1415InformativeInherited
Biological Process (BP)negative regulation of cellular biosynthetic process0.083820.3015InformativeInherited
Biological Process (BP)negative regulation of macromolecule biosynthetic process0.088850.3274InformativeInherited
Biological Process (BP)negative regulation of cellular protein metabolic process0.16780.05523InformativeInherited
Biological Process (BP)translational initiation0.0000000000014550.00000000000005058Highly InformativeDirect
Biological Process (BP)negative regulation of translation0.00018660.0003003Highly InformativeDirect
Biological Process (BP)aging0.00093760.001383Highly InformativeInherited
Molecular Function (MF)binding00Least InformativeDirect
Molecular Function (MF)nucleic acid binding00Moderately InformativeDirect
Molecular Function (MF)enzyme binding00InformativeDirect
Molecular Function (MF)RNA binding00InformativeDirect
Molecular Function (MF)transcription factor binding00Highly InformativeDirect
Molecular Function (MF)translation factor activity, RNA binding0.00000014790.000000003349Highly InformativeDirect
Cellular Component (CC)cytoplasmic part0.00025130.000000004035Least InformativeDirect
Cellular Component (CC)non-membrane-bounded organelle0.012230.2098Least InformativeInherited
Cellular Component (CC)protein complex11Least InformativeInherited
Cellular Component (CC)ribonucleoprotein granule00.0000000000007913InformativeDirect
Cellular Component (CC)perinuclear region of cytoplasm00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular nitrogen compound metabolic process 0.5906 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.3863 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.9822 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) peptide metabolic process 0.000001046 Moderately Informative Direct
Biological Process (BP) amide biosynthetic process 0.0000007647 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0002023 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.2414 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.06301 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.04104 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.06798 Moderately Informative Inherited
Biological Process (BP) gene expression 0.007348 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.002581 Moderately Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 0.0000000000002933 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.000000000001705 Informative Direct
Biological Process (BP) negative regulation of gene expression 0.1415 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 0.3015 Informative Inherited
Biological Process (BP) negative regulation of macromolecule biosynthetic process 0.3274 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.05523 Informative Inherited
Biological Process (BP) translational initiation 0.00000000000005058 Highly Informative Direct
Biological Process (BP) negative regulation of translation 0.0003003 Highly Informative Direct
Biological Process (BP) aging 0.001383 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) enzyme binding 0 Informative Direct
Molecular Function (MF) RNA binding 0 Informative Direct
Molecular Function (MF) transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) translation factor activity, RNA binding 0.000000003349 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.000000004035 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.2098 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) ribonucleoprotein granule 0.0000000000007913 Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranslation regulation0InformativeDirect
Biological processProtein biosynthesis0InformativeDirect
Post-translational modificationRNA-binding0Moderately InformativeDirect
Post-translational modificationInitiation factor0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001040 SSF55418 Protein matches
Abstract Eukaryotic translation initiation factor 4E (eIF-4E) [PubMed1733496] is a protein that binds to the cap structure of eukaryotic cellular mRNAs. eIF-4E recognises and binds the 7-methylguanosine-containing (m7Gppp) cap during an early step in the initiation of protein synthesis and facilitates ribosome binding to a mRNA by inducing the unwinding of its secondary structures. A tryptophan in the central part of the sequence of human eIF-4E seems to be implicated in cap-binding [PubMed1672854].

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a eIF4e-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the eIF4e-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]