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Metalloproteases ("zincins"), catalytic domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Zincin-like [ 55485] (2)
Superfamily:   Metalloproteases ("zincins"), catalytic domain [ 55486] (17)
Families:   Zinc protease [ 55487]
  Fungal zinc peptidase [ 64335]
  Thermolysin-like [ 55490] (4)
  Leukotriene A4 hydrolase catalytic domain [ 64338]
  Neutral endopeptidase (neprilysin) [ 55502]
  Neurolysin-like [ 55505] (4)
  Anthrax toxin lethal factor, N- and C-terminal domains [ 69775]
  Leishmanolysin [ 55499]
  Serralysin-like metalloprotease, catalytic (N-terminal) domain [ 55508]
  Clostridium neurotoxins, catalytic domain [ 55512]
  Astacin [ 55516]
  Reprolysin-like [ 55519] (2)
  TNF-alpha converting enzyme, TACE, catalytic domain [ 55525]
  Matrix metalloproteases, catalytic domain [ 55528] (13)
  Predicted metal-dependent hydrolase [ 103132] (3)
  Caur0242-like [ 160552]
  TTHA0227-like [ 160555] (2)


Superfamily statistics
Genomes (3,225) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 41,885 260,990 143
Proteins 40,939 257,291 141


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0InformativeDirect
Enzyme Commission (EC)Aminopeptidases1InformativeInherited
Enzyme Commission (EC)Leukotriene-A(4) hydrolase0Highly InformativeDirect
Enzyme Commission (EC)Metallocarboxypeptidases0.1001Highly InformativeInherited

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.01386Least InformativeInherited
Disease Ontology (DO)nervous system disease0.5698Least InformativeInherited
Disease Ontology (DO)artery disease0.00000008557Moderately InformativeDirect
Disease Ontology (DO)cell type cancer0.0005424Moderately InformativeDirect
Disease Ontology (DO)sensory system disease0.07454Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.2907Moderately InformativeInherited
Disease Ontology (DO)atherosclerosis0.000000006956InformativeDirect
Disease Ontology (DO)myopia0.000001953InformativeDirect
Disease Ontology (DO)breast cancer0.0000616InformativeDirect
Disease Ontology (DO)prostate cancer0.0006591InformativeDirect
Disease Ontology (DO)intrinsic cardiomyopathy0.0006702InformativeDirect
Disease Ontology (DO)female reproductive system disease0.0008879InformativeDirect
Disease Ontology (DO)connective tissue cancer0.128InformativeInherited
Disease Ontology (DO)malignant glioma0.1765InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.8287InformativeInherited
Disease Ontology (DO)adult astrocytic tumour0.000001452Highly InformativeDirect
Disease Ontology (DO)Kawasaki disease0.00002375Highly InformativeDirect
Disease Ontology (DO)chondrosarcoma0.00004579Highly InformativeDirect
Disease Ontology (DO)salivary gland adenoid cystic carcinoma0.00006417Highly InformativeDirect
Disease Ontology (DO)integumentary system cancer0.00009566Highly InformativeDirect
Disease Ontology (DO)abdominal aortic aneurysm0.0001052Highly InformativeDirect
Disease Ontology (DO)otitis media0.0005657Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.02694Least InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.03847Moderately InformativeInherited
Mammalian Phenotype (MP)limbs/digits/tail phenotype0.06617Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.1706Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.225Moderately InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype0.2448Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.249Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.2564Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.2892Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.3362Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.7221Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.775Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.001654InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.002733InformativeInherited
Mammalian Phenotype (MP)altered tumor pathology0.003207InformativeInherited
Mammalian Phenotype (MP)abnormal limb morphology0.01431InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton development0.02881InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.04182InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.04276InformativeInherited
Mammalian Phenotype (MP)abnormal hypaxial muscle morphology0.05518InformativeInherited
Mammalian Phenotype (MP)abnormal bone ossification0.3854InformativeInherited
Mammalian Phenotype (MP)double outlet right ventricle0.00002044Highly InformativeDirect
Mammalian Phenotype (MP)abnormal long bone hypertrophic chondrocyte zone0.00008278Highly InformativeDirect
Mammalian Phenotype (MP)decreased susceptibility to induced choroidal neovascularization0.0001469Highly InformativeDirect
Mammalian Phenotype (MP)abnormal kidney corticomedullary boundary morphology0.0002117Highly InformativeDirect
Mammalian Phenotype (MP)abnormal fertilization0.0006932Highly InformativeDirect
Mammalian Phenotype (MP)decreased length of long bones0.001053Highly InformativeInherited
Mammalian Phenotype (MP)abnormal retinal vasculature morphology0.0247Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hindlimb morphology0.1156Highly InformativeInherited
Mammalian Phenotype (MP)abnormal limb long bone morphology0.1648Highly InformativeInherited
Mammalian Phenotype (MP)abnormal diaphragm morphology0.2225Highly InformativeInherited
Mammalian Phenotype (MP)abnormal bone mineralization0.5451Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant0Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0.0000003834InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)somatic cell0.7388Least InformativeInherited
Fly Anatomy (FA)developing embryonic structure0.3495Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.4121Moderately InformativeInherited
Fly Anatomy (FA)primordium0.125InformativeInherited
Fly Anatomy (FA)dorsal closure embryo0.1912InformativeInherited
Fly Anatomy (FA)heart primordium0.00005937Highly InformativeDirect
Fly Anatomy (FA)embryonic heart cardioblast0.00005937Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo1Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.2884Moderately InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage0.1195Least InformativeInherited
Xenopus DEvelopment stage (XDE)premetamorphosis stage0.000003477Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)Omega peptidases1InformativeInherited
Enzyme Commission (EC)Acting on ether bonds0Highly InformativeDirect
Enzyme Commission (EC)Metallocarboxypeptidases0.009709Highly InformativeInherited
Enzyme Commission (EC)Aminopeptidases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details) Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 56 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Metalloproteases ("zincins"), catalytic domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 56 hidden Markov models representing the Metalloproteases ("zincins"), catalytic domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]