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SH2 domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   SH2-like [ 55549]
Superfamily:   SH2 domain [ 55550]
Families:   SH2 domain [ 55551] (34)


Superfamily statistics
Genomes (456) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 14,438 41,145 94
Proteins 12,967 36,814 90


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.000006817Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000002804Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.00007356Moderately InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0.0000000000000101InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.0001895InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-3,4,5-trisphosphate 5-phospha0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.0001116Least InformativeDirect
Disease Ontology (DO)disease by infectious agent0.0001827Moderately InformativeDirect
Disease Ontology (DO)hematopoietic system disease0.03907Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.8738Moderately InformativeInherited
Disease Ontology (DO)breast cancer0.000961InformativeDirect
Disease Ontology (DO)myeloid leukemia0.302InformativeInherited
Disease Ontology (DO)myeloid neoplasm1InformativeInherited
Disease Ontology (DO)bone marrow disease0.0000003482Highly InformativeDirect
Disease Ontology (DO)in situ carcinoma0.0003699Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.01162Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.02121Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.6331Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.000006253Moderately InformativeDirect
Phenotypic Abnormality (PA)Neoplasm0.00003019Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of connective tissue0.08557Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.475Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cellular immune system morphology0.00000125InformativeDirect
Phenotypic Abnormality (PA)Unusual CNS infection0.000005053InformativeDirect
Phenotypic Abnormality (PA)Abnormal thrombocyte morphology0.01564InformativeInherited
Phenotypic Abnormality (PA)Abnormal cellular physiology0.01842InformativeInherited
Phenotypic Abnormality (PA)Abnormality of temperature regulation0.02444InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin physiology0.03375InformativeInherited
Phenotypic Abnormality (PA)Abnormal platelet count0.000001595Highly InformativeDirect
Phenotypic Abnormality (PA)Cellulitis0.00003702Highly InformativeDirect
Phenotypic Abnormality (PA)Fever0.0002067Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of bone marrow cell morphology0.07385Highly InformativeInherited
Phenotypic Abnormality (PA)Inflammatory abnormality of the skin0.1735Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.0000000003482Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.0000000006187Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.1049Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.1749Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.4783Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.00000001077Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.000002017Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.0001488Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune system organ morphology0.0006276Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0.02191Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.02204Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.02721Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body composition0.03106Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.0345Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.0349Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.07146Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.07569Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.1841Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.2449Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell proliferation0.000000001923InformativeDirect
Mammalian Phenotype (MP)autoimmune response0.000001422InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.000005524InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation0.0001161InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.0002421InformativeDirect
Mammalian Phenotype (MP)abnormal liver physiology0.0008615InformativeDirect
Mammalian Phenotype (MP)abnormal spleen morphology0.0009342InformativeDirect
Mammalian Phenotype (MP)abnormal interferon level0.03206InformativeInherited
Mammalian Phenotype (MP)abnormal effector T cell morphology0.04811InformativeInherited
Mammalian Phenotype (MP)abnormal B lymphocyte antigen presentation0.0589InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell morphology0.06235InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.06777InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.1473InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level0.1513InformativeInherited
Mammalian Phenotype (MP)abnormal lean body mass0.191InformativeInherited
Mammalian Phenotype (MP)decreased T cell number0.2401InformativeInherited
Mammalian Phenotype (MP)abnormal interferon secretion0.2761InformativeInherited
Mammalian Phenotype (MP)abnormal natural killer cell mediated cytotoxicity0.3572InformativeInherited
Mammalian Phenotype (MP)abnormal B-1 B cell number0.0000004525Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating interleukin-17 level0.0001545Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.0003315Highly InformativeDirect
Mammalian Phenotype (MP)decreased thymocyte number0.0004019Highly InformativeDirect
Mammalian Phenotype (MP)decreased immature B cell number0.0004756Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B cell apoptosis0.000529Highly InformativeDirect
Mammalian Phenotype (MP)increased lean body mass0.0006637Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pre-B cell morphology0.0008321Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.02604Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.03852Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.2905Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.2912Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.3979Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.6198Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.0000115Moderately InformativeDirect
Worm Phenotype (WP)drug response variant0.245Moderately InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.000000000001436InformativeDirect
Worm Phenotype (WP)cell component localization variant0.00000001397InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00000002433InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.00000002769InformativeDirect
Worm Phenotype (WP)level of protein expression variant0.0003515InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.004065InformativeInherited
Worm Phenotype (WP)drug resistant0.3296InformativeInherited
Worm Phenotype (WP)muscle cell attachment variant0.00000000000001611Highly InformativeDirect
Worm Phenotype (WP)protein expression reduced0.0000000004988Highly InformativeDirect
Worm Phenotype (WP)aldicarb resistant0.000874Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)planar polarity defective0.00003104InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.01095Least InformativeInherited
Fly Anatomy (FA)adult0.01386Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.01698Least InformativeInherited
Fly Anatomy (FA)nervous system0.1309Least InformativeInherited
Fly Anatomy (FA)somatic cell0.5956Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)adult segment0.0002077Moderately InformativeDirect
Fly Anatomy (FA)acellular anatomical structure0.0007756Moderately InformativeDirect
Fly Anatomy (FA)adult nervous system0.002095Moderately InformativeInherited
Fly Anatomy (FA)gonad0.01882Moderately InformativeInherited
Fly Anatomy (FA)appendage0.06001Moderately InformativeInherited
Fly Anatomy (FA)sensory system0.08684Moderately InformativeInherited
Fly Anatomy (FA)neuron0.1069Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.1269Moderately InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.1718Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.1853Moderately InformativeInherited
Fly Anatomy (FA)head0.1929Moderately InformativeInherited
Fly Anatomy (FA)thorax0.2498Moderately InformativeInherited
Fly Anatomy (FA)region of integument0.2909Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.5548Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.7726Moderately InformativeInherited
Fly Anatomy (FA)stem cell0.867Moderately InformativeInherited
Fly Anatomy (FA)wing blade0.00099InformativeDirect
Fly Anatomy (FA)tract0.005618InformativeInherited
Fly Anatomy (FA)eye photoreceptor cell0.01131InformativeInherited
Fly Anatomy (FA)germline cyst0.03723InformativeInherited
Fly Anatomy (FA)male organism0.244InformativeInherited
Fly Anatomy (FA)photoreceptor cell R70.00008537Highly InformativeDirect
Fly Anatomy (FA)connective0.0009696Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0.1278Least InformativeInherited
Zebrafish Anatomy (ZA)cell0.139Least InformativeInherited
Zebrafish Anatomy (ZA)hematopoietic cell0.0004603InformativeDirect
Zebrafish Anatomy (ZA)hematopoietic system0.02104InformativeInherited
Zebrafish Anatomy (ZA)portion of organism substance0.003525Highly InformativeInherited
Zebrafish Anatomy (ZA)mononuclear phagocyte0.1926Highly InformativeInherited
Zebrafish Anatomy (ZA)professional antigen presenting cell0.3082Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo1Least InformativeInherited
Xenopus ANatomical entity (XAN)animal hemisphere0.01292InformativeInherited
Xenopus ANatomical entity (XAN)animal pole0.000917Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0000007648Moderately InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.0000008211Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.000000001023InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.00003264InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.00005895InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C2.558e-16Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 73 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SH2 domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 73 hidden Markov models representing the SH2 domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]