SUPERFAMILY 1.75 HMM library and genome assignments server

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SH2 domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   SH2-like [ 55549]
Superfamily:   SH2 domain [ 55550]
Families:   SH2 domain [ 55551] (34)


Superfamily statistics
Genomes (456) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 14,438 41,145 94
Proteins 12,967 36,814 90


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.000006817Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000002804Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.00007356Moderately InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0.0000000000000101InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.0001895InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-3,4,5-trisphosphate 5-phospha0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.0001116Least InformativeDirect
Disease Ontology (DO)disease by infectious agent0.0001827Moderately InformativeDirect
Disease Ontology (DO)hematopoietic system disease0.03907Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.8738Moderately InformativeInherited
Disease Ontology (DO)breast cancer0.000961InformativeDirect
Disease Ontology (DO)myeloid leukemia0.302InformativeInherited
Disease Ontology (DO)myeloid neoplasm1InformativeInherited
Disease Ontology (DO)bone marrow disease0.0000003482Highly InformativeDirect
Disease Ontology (DO)in situ carcinoma0.0003699Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Somatic mutation0.0006853InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.01608Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.05081Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.6218Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.00002755Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.00004252Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.000166Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of connective tissue0.126Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.511Moderately InformativeInherited
Phenotypic Abnormality (PA)Unusual CNS infection0.000008293InformativeDirect
Phenotypic Abnormality (PA)Abnormal thrombocyte morphology0.008235InformativeInherited
Phenotypic Abnormality (PA)Abnormality of temperature regulation0.01318InformativeInherited
Phenotypic Abnormality (PA)Abnormal cellular physiology0.02773InformativeInherited
Phenotypic Abnormality (PA)Cellulitis0.00003639Highly InformativeDirect
Phenotypic Abnormality (PA)Autoimmunity0.0004825Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of bone marrow cell morphology0.03221Highly InformativeInherited
Phenotypic Abnormality (PA)Inflammatory abnormality of the skin0.1655Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.0000000007331Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.000000001273Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.1208Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.1945Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.51Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.00000001076Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.000001975Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.0001933Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune system organ morphology0.0006273Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0.02191Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.02437Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.02722Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.03436Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.035Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body composition0.03551Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.07128Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.08628Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.1841Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.2439Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell proliferation0.000000002263InformativeDirect
Mammalian Phenotype (MP)autoimmune response0.000001679InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.000005525InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation0.0001161InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.0002423InformativeDirect
Mammalian Phenotype (MP)abnormal spleen morphology0.0009334InformativeDirect
Mammalian Phenotype (MP)abnormal liver physiology0.0009473InformativeDirect
Mammalian Phenotype (MP)abnormal interferon level0.03206InformativeInherited
Mammalian Phenotype (MP)abnormal effector T cell morphology0.04809InformativeInherited
Mammalian Phenotype (MP)abnormal B lymphocyte antigen presentation0.05924InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell morphology0.06317InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.06777InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.1473InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level0.1512InformativeInherited
Mammalian Phenotype (MP)abnormal lean body mass0.1911InformativeInherited
Mammalian Phenotype (MP)decreased T cell number0.24InformativeInherited
Mammalian Phenotype (MP)abnormal interferon secretion0.2732InformativeInherited
Mammalian Phenotype (MP)abnormal natural killer cell mediated cytotoxicity0.3572InformativeInherited
Mammalian Phenotype (MP)abnormal B-1 B cell number0.0000005062Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating interleukin-17 level0.0001611Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.0003436Highly InformativeDirect
Mammalian Phenotype (MP)decreased thymocyte number0.0004018Highly InformativeDirect
Mammalian Phenotype (MP)decreased immature B cell number0.0004753Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B cell apoptosis0.0005286Highly InformativeDirect
Mammalian Phenotype (MP)increased lean body mass0.0007082Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pre-B cell morphology0.000831Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.02774Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.03364Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.2672Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.5291Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.0000124Moderately InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.000000000006148InformativeDirect
Worm Phenotype (WP)cell component localization variant0.00000001593InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00000002637InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.00000004436InformativeDirect
Worm Phenotype (WP)level of protein expression variant0.0003468InformativeDirect
Worm Phenotype (WP)muscle cell attachment variant0.00000000000001699Highly InformativeDirect
Worm Phenotype (WP)protein expression reduced0.0000000005406Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)planar polarity defective0.00003152InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.006753Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.0106Least InformativeInherited
Fly Anatomy (FA)organism subdivision0.04448Least InformativeInherited
Fly Anatomy (FA)nervous system0.1015Least InformativeInherited
Fly Anatomy (FA)adult0.1027Least InformativeInherited
Fly Anatomy (FA)larva0.4513Least InformativeInherited
Fly Anatomy (FA)cell0.8697Least InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.0002623Moderately InformativeDirect
Fly Anatomy (FA)adult segment0.0004778Moderately InformativeDirect
Fly Anatomy (FA)portion of tissue0.002088Moderately InformativeInherited
Fly Anatomy (FA)gonad0.02399Moderately InformativeInherited
Fly Anatomy (FA)adult tagma0.02687Moderately InformativeInherited
Fly Anatomy (FA)embryo0.04392Moderately InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.1082Moderately InformativeInherited
Fly Anatomy (FA)sensory system0.1136Moderately InformativeInherited
Fly Anatomy (FA)neuron0.1472Moderately InformativeInherited
Fly Anatomy (FA)head0.1895Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.1896Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.4812Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.6637Moderately InformativeInherited
Fly Anatomy (FA)stem cell0.7477Moderately InformativeInherited
Fly Anatomy (FA)histaminergic neuron0.00001811InformativeDirect
Fly Anatomy (FA)rhabdomeric photoreceptor cell0.00002394InformativeDirect
Fly Anatomy (FA)adult optic lobe neuron0.00004913InformativeDirect
Fly Anatomy (FA)sensory organ cell0.0003793InformativeDirect
Fly Anatomy (FA)tract0.001276InformativeInherited
Fly Anatomy (FA)retina0.005253InformativeInherited
Fly Anatomy (FA)adult head sensillum0.006045InformativeInherited
Fly Anatomy (FA)germline cyst0.05443InformativeInherited
Fly Anatomy (FA)male organism0.2614InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval system0.2934InformativeInherited
Fly Anatomy (FA)embryonic midline of ventral nerve cord0.0000295Highly InformativeDirect
Fly Anatomy (FA)photoreceptor cell R70.0001042Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.1451Least InformativeInherited
Zebrafish Anatomy (ZA)hematopoietic cell0.0004266InformativeDirect
Zebrafish Anatomy (ZA)hematopoietic system0.02281InformativeInherited
Zebrafish Anatomy (ZA)mononuclear phagocyte0.2017Highly InformativeInherited
Zebrafish Anatomy (ZA)professional antigen presenting cell0.3319Highly InformativeInherited
Zebrafish Anatomy (ZA)blood0.566Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo1Least InformativeInherited
Xenopus ANatomical entity (XAN)animal hemisphere0.01253InformativeInherited
Xenopus ANatomical entity (XAN)animal pole0.0008722Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0.000000868Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000001014Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.000000001114InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.000001431InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.00005675InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C2.574e-16Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 73 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SH2 domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 73 hidden Markov models representing the SH2 domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]