SUPERFAMILY 1.75 HMM library and genome assignments server

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SH2 domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   SH2-like [ 55549]
Superfamily:   SH2 domain [ 55550]
Families:   SH2 domain [ 55551] (34)

Superfamily statistics
Genomes (456) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 14,438 41,145 94
Proteins 12,967 36,814 90

Functional annotation
General category Regulation
Detailed category Signal transduction

Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.000006817Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000002804Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.00007356Moderately InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0.0000000000000101InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.0001895InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-3,4,5-trisphosphate 5-phospha0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.000111Least InformativeDirect
Disease Ontology (DO)disease by infectious agent0.0001827Moderately InformativeDirect
Disease Ontology (DO)hematopoietic system disease0.03905Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.8738Moderately InformativeInherited
Disease Ontology (DO)breast cancer0.0009596InformativeDirect
Disease Ontology (DO)myeloid leukemia0.3021InformativeInherited
Disease Ontology (DO)myeloid neoplasm1InformativeInherited
Disease Ontology (DO)bone marrow disease0.0000003482Highly InformativeDirect
Disease Ontology (DO)in situ carcinoma0.0003695Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.02267Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.6352Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.000189Moderately InformativeDirect
Phenotypic Abnormality (PA)Neoplasm0.0003818Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.001301Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.06799Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.4779Moderately InformativeInherited
Phenotypic Abnormality (PA)Unusual CNS infection0.000003917InformativeDirect
Phenotypic Abnormality (PA)Abnormal cellular physiology0.01241InformativeInherited
Phenotypic Abnormality (PA)Abnormal immune system morphology0.02039InformativeInherited
Phenotypic Abnormality (PA)Abnormality of temperature regulation0.03096InformativeInherited
Phenotypic Abnormality (PA)Cellulitis0.00002134Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal platelet count0.00004183Highly InformativeDirect
Phenotypic Abnormality (PA)Autoimmunity0.0001371Highly InformativeDirect
Phenotypic Abnormality (PA)Fever0.0004574Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.0000000007333Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.000000001272Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.1216Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.195Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.51Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.00000001077Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.000002086Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.0001959Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune system organ morphology0.0006434Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0.02201Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.02437Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.02722Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.03449Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.0349Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body composition0.03551Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.07146Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.08669Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.1847Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.2482Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell proliferation0.000000002489InformativeDirect
Mammalian Phenotype (MP)autoimmune response0.000001676InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.00000552InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation0.0001155InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.0002384InformativeDirect
Mammalian Phenotype (MP)abnormal liver physiology0.0009515InformativeDirect
Mammalian Phenotype (MP)abnormal spleen morphology0.0009582InformativeDirect
Mammalian Phenotype (MP)abnormal interferon level0.03205InformativeInherited
Mammalian Phenotype (MP)abnormal effector T cell morphology0.04811InformativeInherited
Mammalian Phenotype (MP)abnormal B lymphocyte antigen presentation0.05864InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell morphology0.06288InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.06696InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.1461InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level0.1513InformativeInherited
Mammalian Phenotype (MP)abnormal lean body mass0.1908InformativeInherited
Mammalian Phenotype (MP)decreased T cell number0.2402InformativeInherited
Mammalian Phenotype (MP)abnormal interferon secretion0.2762InformativeInherited
Mammalian Phenotype (MP)abnormal natural killer cell mediated cytotoxicity0.3572InformativeInherited
Mammalian Phenotype (MP)abnormal B-1 B cell number0.0000005611Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating interleukin-17 level0.000161Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.0003438Highly InformativeDirect
Mammalian Phenotype (MP)decreased thymocyte number0.0004025Highly InformativeDirect
Mammalian Phenotype (MP)decreased immature B cell number0.0004621Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B cell apoptosis0.0005254Highly InformativeDirect
Mammalian Phenotype (MP)increased lean body mass0.0007105Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pre-B cell morphology0.0008195Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.01465Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.02569Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.231Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.3949Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.5987Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.00001073Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.01082Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.1028Moderately InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.00000000000006837InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00000002308InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.00000003514InformativeDirect
Worm Phenotype (WP)cell component localization variant0.00000005229InformativeDirect
Worm Phenotype (WP)level of protein expression variant0.0003495InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.004055InformativeInherited
Worm Phenotype (WP)drug resistant0.3079InformativeInherited
Worm Phenotype (WP)mitochondria alignment variant0.00000000000006128Highly InformativeDirect
Worm Phenotype (WP)protein expression reduced0.0000000004723Highly InformativeDirect
Worm Phenotype (WP)aldicarb resistant0.0008739Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)planar polarity defective0.00003187InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.01057Least InformativeInherited
Fly Anatomy (FA)adult0.01369Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.01654Least InformativeInherited
Fly Anatomy (FA)nervous system0.1261Least InformativeInherited
Fly Anatomy (FA)somatic cell0.5869Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)adult segment0.0002035Moderately InformativeDirect
Fly Anatomy (FA)acellular anatomical structure0.0007935Moderately InformativeDirect
Fly Anatomy (FA)adult nervous system0.002085Moderately InformativeInherited
Fly Anatomy (FA)gonad0.01841Moderately InformativeInherited
Fly Anatomy (FA)sensory system0.08436Moderately InformativeInherited
Fly Anatomy (FA)neuron0.102Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.125Moderately InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.1666Moderately InformativeInherited
Fly Anatomy (FA)head0.191Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.5446Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.7694Moderately InformativeInherited
Fly Anatomy (FA)stem cell0.8634Moderately InformativeInherited
Fly Anatomy (FA)tract0.005639InformativeInherited
Fly Anatomy (FA)eye photoreceptor cell0.01148InformativeInherited
Fly Anatomy (FA)germline cyst0.03733InformativeInherited
Fly Anatomy (FA)male organism0.2413InformativeInherited
Fly Anatomy (FA)photoreceptor cell R70.00008587Highly InformativeDirect
Fly Anatomy (FA)connective0.0009707Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0.1096Least InformativeInherited
Zebrafish Anatomy (ZA)cell0.1363Least InformativeInherited
Zebrafish Anatomy (ZA)hematopoietic cell0.0004608InformativeDirect
Zebrafish Anatomy (ZA)hematopoietic system0.02006InformativeInherited
Zebrafish Anatomy (ZA)portion of organism substance0.003578Highly InformativeInherited
Zebrafish Anatomy (ZA)mononuclear phagocyte0.1813Highly InformativeInherited
Zebrafish Anatomy (ZA)professional antigen presenting cell0.306Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo1Least InformativeInherited
Xenopus ANatomical entity (XAN)animal hemisphere0.01197InformativeInherited
Xenopus ANatomical entity (XAN)animal pole0.0009038Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0.000000778Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000002015Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.0000000009595InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.00002365InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.00003105InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C2.548e-16Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 73 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a SH2 domain domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 73 hidden Markov models representing the SH2 domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]