SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


SH2 domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   SH2-like [ 55549]
Superfamily:   SH2 domain [ 55550]
Family:   SH2 domain [ 55551] (34)


Family statistics
Genomes (151) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 6,490 17,735 94
Proteins 5,791 15,739 90


Enzyme Commission (EC)

(
show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.000003398Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.00000292Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.0000009323InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.0002255InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0.00000000000001293Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.0001081Least InformativeDirect
Disease Ontology (DO)disease by infectious agent0.0002563Moderately InformativeDirect
Disease Ontology (DO)hematopoietic system disease0.03269Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.8423Moderately InformativeInherited
Disease Ontology (DO)myeloid leukemia0.2508InformativeInherited
Disease Ontology (DO)myeloid neoplasm1InformativeInherited
Disease Ontology (DO)bone marrow disease0.0000001686Highly InformativeDirect
Disease Ontology (DO)in situ carcinoma0.0003455Highly InformativeDirect
Disease Ontology (DO)mumps0.0005333Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Somatic mutation0.0007145Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the immune system0.002581Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.01377Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.04354Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.5639Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.00002279Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.00003831Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of connective tissue0.1049Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal homeostasis0.1762Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.4568Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal platelet count0.0000007009InformativeDirect
Phenotypic Abnormality (PA)Fever0.00006049InformativeDirect
Phenotypic Abnormality (PA)Abnormal leukocyte morphology0.00284InformativeInherited
Phenotypic Abnormality (PA)Unusual infection by anatomical site0.003199InformativeInherited
Phenotypic Abnormality (PA)Abnormal cellular physiology0.01604InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin physiology0.02896InformativeInherited
Phenotypic Abnormality (PA)Cellulitis0.00001813Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of multiple cell lineages in the bone marrow0.00009353Highly InformativeDirect
Phenotypic Abnormality (PA)Autoimmunity0.0004601Highly InformativeDirect
Phenotypic Abnormality (PA)Neutropenia0.0007359Highly InformativeDirect
Phenotypic Abnormality (PA)Inflammatory abnormality of the skin0.154Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.0000000009631Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.000000001381Least InformativeDirect
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.001146Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.1313Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.2003Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.5316Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.9022Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.00000001542Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.000001111Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal endocrine gland morphology0.000002389Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune system organ morphology0.0005154Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.003484Moderately InformativeInherited
Mammalian Phenotype (MP)increased hematopoietic cell number0.005072Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.01722Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.02309Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.03054Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body composition0.03681Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.04606Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.06535Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell morphology0.1337Moderately InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.1349Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.1596Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.234Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology0.3124Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal interferon-gamma secretion0.00000000009108InformativeDirect
Mammalian Phenotype (MP)abnormal B cell proliferation0.00000000132InformativeDirect
Mammalian Phenotype (MP)abnormal B-1 B cell number0.0000003571InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.000005297InformativeDirect
Mammalian Phenotype (MP)abnormal spleen morphology0.0007641InformativeDirect
Mammalian Phenotype (MP)increased lymphocyte cell number0.0008594InformativeDirect
Mammalian Phenotype (MP)abnormal innate immunity0.004017InformativeInherited
Mammalian Phenotype (MP)decreased B cell number0.02087InformativeInherited
Mammalian Phenotype (MP)abnormal hepatobiliary system physiology0.02583InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.05616InformativeInherited
Mammalian Phenotype (MP)abnormal antigen presentation0.06415InformativeInherited
Mammalian Phenotype (MP)abnormal circulating interleukin level0.135InformativeInherited
Mammalian Phenotype (MP)decreased T cell number0.1902InformativeInherited
Mammalian Phenotype (MP)impaired natural killer cell mediated cytotoxicity0.000000006199Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating interferon-gamma level0.000001589Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.0001939Highly InformativeDirect
Mammalian Phenotype (MP)decreased thymocyte number0.0002064Highly InformativeDirect
Mammalian Phenotype (MP)decreased immature B cell number0.0002321Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B cell apoptosis0.0002821Highly InformativeDirect
Mammalian Phenotype (MP)increased lean body mass0.0004084Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.568Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.8739Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.0001316Moderately InformativeDirect
Worm Phenotype (WP)cell type morphology variant0.0227Moderately InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.0000000001302InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.0000000619InformativeDirect
Worm Phenotype (WP)cell component localization variant0.00000008929InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.0000001909InformativeDirect
Worm Phenotype (WP)level of protein expression variant0.0003706InformativeDirect
Worm Phenotype (WP)muscle cell attachment variant0.0000000000003613Highly InformativeDirect
Worm Phenotype (WP)protein expression reduced0.00000001058Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)planar polarity defective0.00003322InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.00652Least InformativeInherited
Fly Anatomy (FA)anatomical group0.00673Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.01291Least InformativeInherited
Fly Anatomy (FA)tagma0.03102Least InformativeInherited
Fly Anatomy (FA)segment0.03403Least InformativeInherited
Fly Anatomy (FA)nervous system0.09622Least InformativeInherited
Fly Anatomy (FA)adult0.1006Least InformativeInherited
Fly Anatomy (FA)larva0.4537Least InformativeInherited
Fly Anatomy (FA)somatic cell0.6858Least InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.0002714Moderately InformativeDirect
Fly Anatomy (FA)female-specific anatomical entity0.004491Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.02142Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.02207Moderately InformativeInherited
Fly Anatomy (FA)gonad0.02284Moderately InformativeInherited
Fly Anatomy (FA)adult head0.03299Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.06248Moderately InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.1113Moderately InformativeInherited
Fly Anatomy (FA)neuron0.1498Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.1948Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.49Moderately InformativeInherited
Fly Anatomy (FA)histaminergic neuron0.00002475InformativeDirect
Fly Anatomy (FA)ommatidium0.00006377InformativeDirect
Fly Anatomy (FA)adult optic lobe neuron0.00006618InformativeDirect
Fly Anatomy (FA)photoreceptor cell0.0003184InformativeDirect
Fly Anatomy (FA)sensory organ cell0.0003776InformativeDirect
Fly Anatomy (FA)female germline cyst0.0005758InformativeDirect
Fly Anatomy (FA)tract0.001317InformativeInherited
Fly Anatomy (FA)ovariole0.002299InformativeInherited
Fly Anatomy (FA)male-specific anatomical entity0.2393InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval system0.2556InformativeInherited
Fly Anatomy (FA)somatic stem cell0.6231InformativeInherited
Fly Anatomy (FA)somatic cell of testis0.002499Highly InformativeInherited
Fly Anatomy (FA)germinal proliferation center0.03008Highly InformativeInherited
Fly Anatomy (FA)inner photoreceptor cell0.1368Highly InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval central nervous system0.2336Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.1288Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.4679Moderately InformativeInherited
Zebrafish Anatomy (ZA)hematopoietic cell0.0003345InformativeDirect
Zebrafish Anatomy (ZA)immune system0.0003686InformativeDirect
Zebrafish Anatomy (ZA)motile cell0.006774InformativeInherited
Zebrafish Anatomy (ZA)hematopoietic system0.02076InformativeInherited
Zebrafish Anatomy (ZA)intermediate cell mass of mesoderm0.01084Highly InformativeInherited
Zebrafish Anatomy (ZA)mononuclear phagocyte0.2241Highly InformativeInherited
Zebrafish Anatomy (ZA)professional antigen presenting cell0.3595Highly InformativeInherited
Zebrafish Anatomy (ZA)blood0.5396Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo1Least InformativeInherited
Xenopus ANatomical entity (XAN)animal hemisphere0.01386InformativeInherited
Xenopus ANatomical entity (XAN)animal pole0.0006354Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root0Least InformativeDirect
Plant ANatomical entity (PAN)vascular leaf0Least InformativeDirect
Plant ANatomical entity (PAN)stem0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.000001668Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0.00000009197InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0000007989InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.0000003506Highly InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.0000697Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 73 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a SH2 domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]