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Tetrahydrobiopterin biosynthesis enzymes-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   T-fold [ 55619] (2)
Superfamily:   Tetrahydrobiopterin biosynthesis enzymes-like [ 55620] (4)
Families:   GTP cyclohydrolase I [ 55621]
  6-pyruvoyl tetrahydropterin synthase [ 55625]
  DHN aldolase/epimerase [ 55628] (2)
  Urate oxidase (uricase) [ 55633]


Superfamily statistics
Genomes (2,924) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 10,937 60,225 29
Proteins 10,016 56,501 24


Functional annotation
General category Metabolism
Detailed category Nucleotide metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process0.0000000023170.000000000007072Least InformativeDirect
Biological Process (BP)heterocycle metabolic process0.0000000024260.0000000000001015Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process0.000000010760.0000000000008092Least InformativeDirect
Biological Process (BP)cellular nitrogen compound metabolic process0.000000014090Least InformativeDirect
Biological Process (BP)organonitrogen compound metabolic process0.0000014290.0000000000003604Least InformativeDirect
Biological Process (BP)biosynthetic process0.0010240.0000007936Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.054720.00004286Least InformativeInherited
Biological Process (BP)single-organism cellular process0.39510.5881Least InformativeInherited
Biological Process (BP)cofactor metabolic process0.000000000086160Moderately InformativeDirect
Biological Process (BP)aromatic compound biosynthetic process0.0000015030.00000000003955Moderately InformativeDirect
Biological Process (BP)heterocycle biosynthetic process0.000010140.00000000001303Moderately InformativeDirect
Biological Process (BP)organic cyclic compound biosynthetic process0.000022010.000000000132Moderately InformativeDirect
Biological Process (BP)cellular modified amino acid metabolic process0.000041230.00000002915InformativeDirect
Biological Process (BP)coenzyme biosynthetic process0.011330.00001352InformativeInherited
Biological Process (BP)pteridine-containing compound biosynthetic process00Highly InformativeDirect
Biological Process (BP)folic acid-containing compound metabolic process0.000023890.000000003455Highly InformativeDirect
Molecular Function (MF)binding0.44941Least InformativeInherited
Molecular Function (MF)hydrolase activity0.97040.3755Least InformativeInherited
Molecular Function (MF)lyase activity0.000000000011430.000000001914Moderately InformativeDirect
Molecular Function (MF)identical protein binding0.00013330.0009955InformativeDirect
Molecular Function (MF)hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds0.00022690InformativeDirect
Molecular Function (MF)carbon-carbon lyase activity0.58070.1979InformativeInherited
Molecular Function (MF)carbon-oxygen lyase activity, acting on phosphates0.000000020080.0000002371Highly InformativeDirect
Molecular Function (MF)aldehyde-lyase activity0.000000038270.000000000003506Highly InformativeDirect
Molecular Function (MF)hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines0.00000041030Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.000000000007072 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0000000000001015 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0000000000008092 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.0000000000003604 Least Informative Direct
Biological Process (BP) biosynthetic process 0.0000007936 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.00004286 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.5881 Least Informative Inherited
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.00000000003955 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.00000000001303 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.000000000132 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.4138 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.00000002915 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.00001352 Informative Direct
Biological Process (BP) pteridine-containing compound biosynthetic process 0 Highly Informative Direct
Biological Process (BP) folic acid-containing compound metabolic process 0.000000003455 Highly Informative Direct
Biological Process (BP) cellular modified amino acid biosynthetic process 0.0003532 Highly Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 0.3755 Least Informative Inherited
Molecular Function (MF) lyase activity 0.000000001914 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 0.37 Moderately Informative Inherited
Molecular Function (MF) identical protein binding 0.0009955 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0 Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 0.1979 Informative Inherited
Molecular Function (MF) carbon-oxygen lyase activity, acting on phosphates 0.0000002371 Highly Informative Direct
Molecular Function (MF) aldehyde-lyase activity 0.000000000003506 Highly Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)In cyclic amidines0InformativeDirect
Enzyme Commission (EC)Aldehyde-lyases0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Diphosphotransferases0.0000008852InformativeDirect
Enzyme Commission (EC)Acting on phosphates0.07123InformativeInherited
Enzyme Commission (EC)2-amino-4-hydroxy-6-hydroxymethyldihydropteridine 0.00000000000002438Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processFolate biosynthesis0Highly InformativeDirect
Biological processOne-carbon metabolism0Highly InformativeDirect
Biological processPurine metabolism0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentPeroxisome0InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionNucleotide-binding0.7133Least InformativeInherited
Molecular functionNADP0Moderately InformativeDirect
Molecular functionGTP-binding0InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Tetrahydrobiopterin biosynthesis enzymes-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the Tetrahydrobiopterin biosynthesis enzymes-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]