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Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Class II aaRS and biotin synthetases [ 55680]
Superfamily:   Class II aaRS and biotin synthetases [ 55681] (4)
Family:   Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain [ 55682] (15)


Family statistics
Genomes (3,258) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 36,163 249,493 37
Proteins 36,146 249,446 37


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun0Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0.07742InformativeInherited
Enzyme Commission (EC)Phenylalanine--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Acid--ammonia (or amide) ligases (amide synthases)0Highly InformativeDirect
Enzyme Commission (EC)Threonine--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Proline--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Alanine--tRNA ligase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.06825Least InformativeInherited
Disease Ontology (DO)neuromuscular disease0.00002403Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the musculature0.007017Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.04164Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.195Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.5279Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.7368Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebrum0.0117Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0.01556Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal peripheral nervous system morphology0.1804Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal homeostasis0.3193Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.3523Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.38Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.8983Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature of the limbs0.0004145InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cerebral subcortex0.02471InformativeInherited
Phenotypic Abnormality (PA)Peripheral neuropathy0.1503InformativeInherited
Phenotypic Abnormality (PA)Abnormality of toe0.3099InformativeInherited
Phenotypic Abnormality (PA)Acidosis0.6255InformativeInherited
Phenotypic Abnormality (PA)Hypoplasia of the corpus callosum0.00006748Highly InformativeDirect
Phenotypic Abnormality (PA)Distal sensory impairment0.00006864Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal CNS myelination0.0002029Highly InformativeDirect
Phenotypic Abnormality (PA)Cerebellar atrophy0.000893Highly InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.00001272Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.00007065Least InformativeDirect
Worm Phenotype (WP)cell development variant0.0004393Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0009685Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.002782Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.0000001079Moderately InformativeDirect
Worm Phenotype (WP)germ cell differentiation variant0.000007593Moderately InformativeDirect
Worm Phenotype (WP)germ cell development variant0.0002308Moderately InformativeDirect
Worm Phenotype (WP)organism stress response variant0.002648Moderately InformativeInherited
Worm Phenotype (WP)cell cycle variant0.02139Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.02214Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.04106Moderately InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.08914Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.5437Moderately InformativeInherited
Worm Phenotype (WP)avoids bacterial lawn0.0000000019InformativeDirect
Worm Phenotype (WP)germ cell compartment expansion variant0.0000004172InformativeDirect
Worm Phenotype (WP)pachytene progression during oogenesis variant0.000000891InformativeDirect
Worm Phenotype (WP)hermaphrodite physiology variant0.000001452InformativeDirect
Worm Phenotype (WP)germ cell physiology variant0.000006203InformativeDirect
Worm Phenotype (WP)endocytic transport defect0.000009329InformativeDirect
Worm Phenotype (WP)nuclear positioning variant0.006144InformativeInherited
Worm Phenotype (WP)hypoxia response variant0Highly InformativeDirect
Worm Phenotype (WP)cell differentiation variant0.00000000000003307Highly InformativeDirect
Worm Phenotype (WP)pleiotropic defects severe early emb0.00000000007122Highly InformativeDirect
Worm Phenotype (WP)cytoplasmic processing body variant0.000005596Highly InformativeDirect
Worm Phenotype (WP)germline nuclear positioning variant0.0001032Highly InformativeDirect
Worm Phenotype (WP)germ cell compartment anucleate0.0001261Highly InformativeDirect
Worm Phenotype (WP)diakinesis progression during oogenesis variant0.09021Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.5193Least InformativeInherited
Yeast Phenotype (YP)nutrient utilization0.0498Moderately InformativeInherited
Yeast Phenotype (YP)respiratory metabolism0.004254InformativeInherited
Yeast Phenotype (YP)mitochondrial genome maintenance0.0001023Highly InformativeDirect

Document: YP annotation of SCOP domains

Zebrafish Anatomy (ZA)

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ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0.2296Least InformativeInherited
Zebrafish Anatomy (ZA)head0Moderately InformativeDirect
Zebrafish Anatomy (ZA)cardiovascular system0.02803Moderately InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.5928Moderately InformativeInherited
Zebrafish Anatomy (ZA)vasculature0.01329InformativeInherited
Zebrafish Anatomy (ZA)cranial vasculature0.0005153Highly InformativeDirect
Zebrafish Anatomy (ZA)artery0.0007073Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tail region0.002291Moderately InformativeInherited
Xenopus ANatomical entity (XAN)tail0.0008636InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)0 seed germination stage0.000002682InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases1Least InformativeInherited
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Forming carbon-oxygen bonds0InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases1InformativeInherited
Enzyme Commission (EC)Forming carbon-nitrogen bonds1InformativeInherited
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compounds0Highly InformativeDirect
Enzyme Commission (EC)Acid--ammonia (or amine) ligases (amide synthases)0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 49 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Class II aaRS and biotin synthetases domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]