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Actin depolymerizing proteins superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Gelsolin-like [ 55752] (3)
Superfamily:   Actin depolymerizing proteins [ 55753] (2)
Families:   Gelsolin-like [ 55754] (4)
  Cofilin-like [ 55762] (7)


Superfamily statistics
Genomes (506) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 13,144 32,211 51
Proteins 5,889 14,720 34


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular component organization or biogenesis00Least InformativeDirect
Biological Process (BP)single-organism cellular process0.000056180.00000000000002769Least InformativeDirect
Biological Process (BP)multicellular organismal process0.000010520.08405Least InformativeInherited
Biological Process (BP)biological regulation0.00058280.001065Least InformativeInherited
Biological Process (BP)regulation of cellular component organization0.0000000000066230Moderately InformativeDirect
Biological Process (BP)cell differentiation0.0000034330.0008426Moderately InformativeDirect
Biological Process (BP)regulation of biological quality0.00024290Moderately InformativeDirect
Biological Process (BP)organelle organization0.0067140.000000003258Moderately InformativeInherited
Biological Process (BP)protein complex biogenesis0.59580.001235Moderately InformativeInherited
Biological Process (BP)cellular component assembly10.02013Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.026450.02014Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.76430.3543Moderately InformativeInherited
Biological Process (BP)single-organism transport0.068110.04538Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.035520.0000005446Moderately InformativeInherited
Biological Process (BP)supramolecular fiber organization00InformativeDirect
Biological Process (BP)regulation of anatomical structure size0.000000000061380InformativeDirect
Biological Process (BP)regulation of cellular component biogenesis0.00000011630InformativeDirect
Biological Process (BP)actin cytoskeleton organization0.00000087980InformativeDirect
Biological Process (BP)locomotion0.000027080.0003256InformativeDirect
Biological Process (BP)regulation of organelle organization0.038090.000000006702InformativeInherited
Biological Process (BP)cellular protein complex assembly0.0018660.000000002199InformativeInherited
Biological Process (BP)regulation of nervous system development0.0010490.0316InformativeInherited
Biological Process (BP)generation of neurons0.0023220.4887InformativeInherited
Biological Process (BP)regulation of cell differentiation0.23810.2159InformativeInherited
Biological Process (BP)vesicle-mediated transport0.010960.000008986InformativeInherited
Biological Process (BP)secretion by cell0.083210.1171InformativeInherited
Biological Process (BP)cell cycle process0.00058510.5072InformativeInherited
Biological Process (BP)cellular component disassembly00Highly InformativeDirect
Biological Process (BP)regulation of actin polymerization or depolymerization00Highly InformativeDirect
Biological Process (BP)regulation of protein polymerization0.00000000000010980Highly InformativeDirect
Biological Process (BP)cytokinesis0.000000008010.00008087Highly InformativeDirect
Biological Process (BP)actin filament organization0.000013420Highly InformativeDirect
Biological Process (BP)protein polymerization0.000019140Highly InformativeDirect
Biological Process (BP)regulation of protein complex disassembly0.0014250Highly InformativeInherited
Molecular Function (MF)binding0.00000010.0000001783Least InformativeDirect
Molecular Function (MF)cytoskeletal protein binding00InformativeDirect
Molecular Function (MF)macromolecular complex binding00InformativeDirect
Molecular Function (MF)actin filament binding0.000039350.00000000000003587Highly InformativeDirect
Cellular Component (CC)non-membrane-bounded organelle0.00000036480Least InformativeDirect
Cellular Component (CC)cytoplasmic part0.52590.5923Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.24760.06733Least InformativeInherited
Cellular Component (CC)cytoskeleton0.000000027360Moderately InformativeDirect
Cellular Component (CC)cell projection0.0069480.0000000009611Moderately InformativeInherited
Cellular Component (CC)actin cytoskeleton00InformativeDirect
Cellular Component (CC)cytoplasmic region0.00000000000073150InformativeDirect
Cellular Component (CC)supramolecular polymer0.0001290.00000000001954InformativeDirect
Cellular Component (CC)lamellipodium0.000000000086440.0000000000003209Highly InformativeDirect
Cellular Component (CC)midbody0.000077560.00000755Highly InformativeDirect
Cellular Component (CC)cortical cytoskeleton0.000037920.002258Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00000000000002769 Least Informative Direct
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.08405 Least Informative Inherited
Biological Process (BP) biological regulation 0.001065 Least Informative Inherited
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0008426 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0 Moderately Informative Direct
Biological Process (BP) organelle organization 0.000000003258 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.0000005446 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0002743 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.02014 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.221 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.6341 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.2477 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.607 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.001235 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.1048 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.7825 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.02013 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.8143 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.3543 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.04538 Moderately Informative Inherited
Biological Process (BP) supramolecular fiber organization 0 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) actin cytoskeleton organization 0 Informative Direct
Biological Process (BP) locomotion 0.0003256 Informative Direct
Biological Process (BP) cellular protein complex assembly 0.000000002199 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.000008986 Informative Direct
Biological Process (BP) regulation of organelle organization 0.000000006702 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0000394 Informative Direct
Biological Process (BP) regulation of proteolysis 0.00008456 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.01623 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.01107 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.5396 Informative Inherited
Biological Process (BP) localization of cell 0.02502 Informative Inherited
Biological Process (BP) cell development 0.05162 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.2159 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.0316 Informative Inherited
Biological Process (BP) generation of neurons 0.4887 Informative Inherited
Biological Process (BP) secretion by cell 0.1171 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.4647 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.4988 Informative Inherited
Biological Process (BP) cell cycle process 0.5072 Informative Inherited
Biological Process (BP) cellular component disassembly 0 Highly Informative Direct
Biological Process (BP) regulation of actin polymerization or depolymerization 0 Highly Informative Direct
Biological Process (BP) regulation of protein polymerization 0 Highly Informative Direct
Biological Process (BP) cytokinesis 0.00008087 Highly Informative Direct
Biological Process (BP) actin filament organization 0 Highly Informative Direct
Biological Process (BP) protein polymerization 0 Highly Informative Direct
Biological Process (BP) regulation of protein complex disassembly 0 Highly Informative Direct
Biological Process (BP) negative regulation of supramolecular fiber organization 0 Highly Informative Direct
Biological Process (BP) positive regulation of supramolecular fiber organization 0.00001311 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) negative regulation of protein complex assembly 0 Highly Informative Direct
Biological Process (BP) positive regulation of proteolysis 0.0000002314 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.00000145 Highly Informative Direct
Biological Process (BP) regulation of protein processing 0.00000436 Highly Informative Direct
Biological Process (BP) regulation of response to wounding 0.000008671 Highly Informative Direct
Biological Process (BP) cell projection assembly 0.00001729 Highly Informative Direct
Biological Process (BP) maintenance of location 0.00001944 Highly Informative Direct
Biological Process (BP) phagocytosis 0.0001537 Highly Informative Direct
Biological Process (BP) response to growth factor 0.0002782 Highly Informative Direct
Biological Process (BP) striated muscle cell development 0.0002961 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 1 Highly Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.06812 Highly Informative Inherited
Molecular Function (MF) binding 0.0000001783 Least Informative Direct
Molecular Function (MF) anion binding 0.03754 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 0.01745 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.3154 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.00891 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) macromolecular complex binding 0 Informative Direct
Molecular Function (MF) phospholipid binding 0.00000000003234 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.01158 Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.00232 Informative Inherited
Molecular Function (MF) actin filament binding 0.00000000000003587 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol phosphate binding 0 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0.00000004696 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase inhibitor activity 0.0000002043 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0.000007131 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.5923 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.06733 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0000000009611 Moderately Informative Direct
Cellular Component (CC) vesicle 0.01765 Moderately Informative Inherited
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) cytoplasmic region 0 Informative Direct
Cellular Component (CC) supramolecular polymer 0.00000000001954 Informative Direct
Cellular Component (CC) plasma membrane bounded cell projection part 0.8354 Informative Inherited
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) lamellipodium 0.0000000000003209 Highly Informative Direct
Cellular Component (CC) midbody 0.00000755 Highly Informative Direct
Cellular Component (CC) cell-substrate adherens junction 0.000000005602 Highly Informative Direct
Cellular Component (CC) ruffle 0.00000002121 Highly Informative Direct
Cellular Component (CC) growth cone 0.0003879 Highly Informative Direct
Cellular Component (CC) endocytic vesicle 0.01142 Highly Informative Inherited
Cellular Component (CC) cortical cytoskeleton 0.002258 Highly Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0.0006166Moderately InformativeDirect
Biological processCilium biogenesis/degradation0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentNucleus0.000000919Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0001265Moderately InformativeDirect
Cellular componentEndosome0.0003511Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSH3 domain0.0000000001506InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.0001103Moderately InformativeDirect
Post-translational modificationActin-binding0InformativeDirect
Post-translational modificationActin capping0Highly InformativeDirect
Post-translational modificationGrowth factor0.0000001595Highly InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 25 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Actin depolymerizing proteins domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 25 hidden Markov models representing the Actin depolymerizing proteins superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]