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Ribonuclease Rh-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ribonuclease Rh-like [ 55894]
Superfamily:   Ribonuclease Rh-like [ 55895]
Families:   Ribonuclease Rh-like [ 55896] (8)

Superfamily statistics
Genomes (902) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 1,917 8,635 12
Proteins 1,884 8,605 12

Functional annotation
General category Information
Detailed category RNA processing

Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process0.00029460.000005414Least InformativeDirect
Biological Process (BP)heterocycle metabolic process0.00029920.000004765Least InformativeDirect
Biological Process (BP)cellular nitrogen compound metabolic process0.00054290.00001767Least InformativeDirect
Biological Process (BP)primary metabolic process0.32480.1635Least InformativeInherited
Biological Process (BP)macromolecule metabolic process0.036820.009056Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.018650.00006342Least InformativeInherited
Biological Process (BP)RNA metabolic process0.00000057910.0000000005221Moderately InformativeDirect
Biological Process (BP)cellular catabolic process0.000013360.000000001199Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process0.00096550.000000006662Moderately InformativeDirect
Biological Process (BP)nucleobase-containing compound catabolic process0.000000003970InformativeDirect
Biological Process (BP)cellular macromolecule catabolic process0.000000017690.00000000000004085InformativeDirect
Biological Process (BP)RNA catabolic process0.00000000004020Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.00054740.00002119Least InformativeDirect
Molecular Function (MF)hydrolase activity, acting on ester bonds0.0000050930.0000000003592Moderately InformativeDirect
Molecular Function (MF)nuclease activity0.0000000018240InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.000005414 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.000004765 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.00001767 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.00006342 Least Informative Direct
Biological Process (BP) primary metabolic process 0.1635 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.009056 Least Informative Inherited
Biological Process (BP) RNA metabolic process 0.0000000005221 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.000000001199 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.000000006662 Moderately Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.00000000000004085 Informative Direct
Biological Process (BP) RNA catabolic process 0 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.00002119 Least Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.0000000003592 Moderately Informative Direct
Molecular Function (MF) nuclease activity 0 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.8302Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.05259Least InformativeInherited
Enzyme Commission (EC)Serine endopeptidases0.00001407Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0.00004815Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0.0004788Moderately InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphatase0.0000000001751InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0.00000001353InformativeDirect
Enzyme Commission (EC)Pestivirus NS3 polyprotein peptidase0Highly InformativeDirect
Enzyme Commission (EC)Endoribonucleases producing other than 5'-phosphom0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processHost-virus interaction0.00001159Moderately InformativeDirect
Biological processViral RNA replication0.0000000007086InformativeDirect
Biological processViral immunoevasion0.00000001067InformativeDirect
Biological processVirus entry into host cell0.0000002141InformativeDirect
Biological processInhibition of host IRF3 by virus0.000000000000001917Highly InformativeDirect
Biological processActivation of host autophagy by virus0.0000000000005932Highly InformativeDirect
Biological processFusion of virus membrane with host endosomal membrane0.0000000001188Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentSecreted0.0000000004181Moderately InformativeDirect
Cellular componentVirion0.00001758Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
Cellular componentLysosome0.00000001731InformativeDirect
Cellular componentHost membrane0.0000004893InformativeDirect
DomainSignal0Least InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationNuclease0Moderately InformativeDirect
Post-translational modificationNucleotidyltransferase0.004571Moderately InformativeInherited
Post-translational modificationProtease1Moderately InformativeInherited
Post-translational modificationEndonuclease0InformativeDirect
Post-translational modificationThiol protease0.0000001634InformativeDirect
Post-translational modificationIon channel0.000001037InformativeDirect
Post-translational modificationSerine protease0.000003249InformativeDirect
Post-translational modificationViral ion channel0.0000000000001013Highly InformativeDirect
Post-translational modificationRNA-directed RNA polymerase0.000000000422Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationGlycoprotein0.00000000000002451Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001568 SSF55895 Protein matches

The fungal ribonucleases T2 from Aspergillus oryzae, M from Aspergillus saitoi and Rh from Rhizopus niveus are structurally and functionally related 30 Kd glycoproteins [PubMed2229029] that cleave the 3'-5' internucleotide linkage of RNA via a nucleotide 2',3'-cyclic phosphate intermediate .

Two histidines residues have been shown [PubMed2298207, PubMed1633875] to be involved in the catalytic mechanism of RNase T2 and Rh. These residues and the region around them are highly conserved in a number of other RNAses that have been found to be evolutionary related to these fungal enzymes.

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Ribonuclease Rh-like domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Ribonuclease Rh-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]