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Pentein superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Pentein, beta/alpha-propeller [ 55908]
Superfamily:   Pentein [ 55909] (7)
Families:   Ribosome anti-association factor eIF6 (aIF6) [ 55910]
  Amidinotransferase [ 55914] (2)
  Dimethylarginine dimethylaminohydrolase DDAH [ 64380]
  Arginine deiminase [ 103232]
  Peptidylarginine deiminase Pad4, catalytic C-terminal domain [ 111152]
  Porphyromonas-type peptidylarginine deiminase [ 111155] (2)
  Succinylarginine dihydrolase-like [ 143809]


Superfamily statistics
Genomes (2,297) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 5,034 28,197 27
Proteins 4,973 28,114 27


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.66671Least InformativeInherited
Biological Process (BP)single-organism cellular process0.022790.3257Least InformativeInherited
Biological Process (BP)biological regulation0.17891Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process0.0012450.000001148Least InformativeInherited
Biological Process (BP)primary metabolic process0.13890.07197Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.039570.001775Least InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.00000000014630.0000000000003232Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process0.000044330.02874Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.00037430.2519Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.0051620.06898Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.00000063090.02752Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.013350.6009Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.056060.3946Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.38540.1461Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.080510.3406Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.38940.7366Moderately InformativeInherited
Biological Process (BP)response to organic substance0.028680.1134Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.00094410.008868Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.026950.09496Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.028040.009325Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.04880.112Moderately InformativeInherited
Biological Process (BP)posttranscriptional regulation of gene expression0.00000047980.00007681InformativeDirect
Biological Process (BP)positive regulation of cellular biosynthetic process0.000010750.0006329InformativeDirect
Biological Process (BP)regulation of cellular amide metabolic process0.000065680.00003741InformativeDirect
Biological Process (BP)response to nitrogen compound0.00080220.017InformativeInherited
Biological Process (BP)negative regulation of cellular biosynthetic process0.032340.2696InformativeInherited
Biological Process (BP)negative regulation of cellular protein metabolic process0.00002540.002633InformativeInherited
Biological Process (BP)negative regulation of macromolecule biosynthetic process0.000013610.05554InformativeInherited
Biological Process (BP)negative regulation of gene expression0.00011090.1137InformativeInherited
Biological Process (BP)carboxylic acid catabolic process0.071250.04153InformativeInherited
Biological Process (BP)glutamine family amino acid metabolic process0.00022690.001685InformativeInherited
Biological Process (BP)arginine metabolic process00Highly InformativeDirect
Biological Process (BP)glutamine family amino acid catabolic process0.00013870.000003738Highly InformativeDirect
Biological Process (BP)gene silencing0.00000001260.0000239Highly InformativeDirect
Biological Process (BP)negative regulation of translation0.0000000011270.000002419Highly InformativeDirect
Biological Process (BP)regulation of gene expression, epigenetic0.0000000018860.000002244Highly InformativeDirect
Biological Process (BP)regulation of reactive oxygen species biosynthetic process0.000021470.00000009237Highly InformativeDirect
Biological Process (BP)positive regulation of reactive oxygen species metabolic process0.000040150.000001464Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.00000050580.000000179Least InformativeDirect
Molecular Function (MF)hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds00InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) organonitrogen compound metabolic process 0.000001148 Least Informative Direct
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.3257 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.07197 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.001775 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.4779 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.0000000000003232 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.02874 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.2519 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.06898 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.02752 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.6009 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.3946 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.1461 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.1292 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.01773 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.3406 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.04569 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.7366 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1134 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.008868 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.009325 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.112 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.09496 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.07628 Moderately Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.00007681 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.00000007335 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.0006329 Informative Direct
Biological Process (BP) regulation of cellular amide metabolic process 0.00003741 Informative Direct
Biological Process (BP) response to nitrogen compound 0.017 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 0.2696 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.002633 Informative Inherited
Biological Process (BP) negative regulation of macromolecule biosynthetic process 0.05554 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.1137 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.04153 Informative Inherited
Biological Process (BP) glutamine family amino acid metabolic process 0.001685 Informative Inherited
Biological Process (BP) chromosome organization 0.01864 Informative Inherited
Biological Process (BP) arginine metabolic process 0 Highly Informative Direct
Biological Process (BP) glutamine family amino acid catabolic process 0.000003738 Highly Informative Direct
Biological Process (BP) gene silencing 0.0000239 Highly Informative Direct
Biological Process (BP) negative regulation of translation 0.000002419 Highly Informative Direct
Biological Process (BP) regulation of gene expression, epigenetic 0.000002244 Highly Informative Direct
Biological Process (BP) regulation of reactive oxygen species biosynthetic process 0.00000009237 Highly Informative Direct
Biological Process (BP) positive regulation of reactive oxygen species metabolic process 0.000001464 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.000000179 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring one-carbon groups 0.000000000000589 Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0 Informative Direct
Molecular Function (MF) transferase activity, transferring nitrogenous groups 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)In linear amidines0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processProtein biosynthesis0InformativeDirect
Biological processRibosome biogenesis0.0000000001032InformativeDirect
Biological processArginine metabolism0Highly InformativeDirect
Biological processPolyamine biosynthesis9.645e-16Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationInitiation factor0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 15 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Pentein domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 15 hidden Markov models representing the Pentein superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]